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{"akg_c": -1.0, "indpyr_c": 1.0, "glu__L_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTA", "gene_reaction_rule": "Mbar_A3133 or Mbar_A2083 or Mbar_A3463"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophanyl-tRNA synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "trnatrp_c": -1.0, "amp_c": 1.0, "trptrna_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTRS", "gene_reaction_rule": "Mbar_A1374"}, {"subsystem": "Cysteine Metabolism", "name": "TSR", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSR"]}, "metabolites": {"tsul_c": -1.0, "so3_c": 1.0, "h2_c": -1.0, "h2s_c": 1.0}, "id": "TSR", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "TSULabc", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSULabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "tsul_e": -1.0, "pi_c": 1.0, "tsul_c": 1.0}, "id": "TSULabc", "gene_reaction_rule": "(Mbar_A2559 or Mbar_A1557 or Mbar_A1306) and (Mbar_A1307 or Mbar_A1558 or Mbar_A2560) and (Mbar_A1556 or Mbar_A1305) and Mbar_A1559"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tyrosine transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["TYRTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "34hpp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTA", "gene_reaction_rule": "Mbar_A2083 or Mbar_A3463 or Mbar_A3133"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tyrosyl-tRNA synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "tyrtrna_c": 1.0, "trnatyr_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTRS", "gene_reaction_rule": "Mbar_A1745"}, {"subsystem": "Lipid & Cell Wall Metabolism", "name": "UDP-N-acetylglucosamine 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{"subsystem": "Nucleotide Metabolism", "name": "UMP kinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UMPK", "URIDK1"]}, "metabolites": {"ump_c": -1.0, "udp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "UMPK_copy2", "gene_reaction_rule": "Mbar_A0788"}, {"subsystem": "Nucleotide Metabolism", "name": "Uridylate kinase (dUMP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["URIDK2r"]}, "metabolites": {"adp_c": 1.0, "dudp_c": 1.0, "dump_c": -1.0, "atp_c": -1.0}, "id": "URIDK2r", "gene_reaction_rule": "Mbar_A0788"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valine transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["VALTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "3mob_c": 1.0, "val__L_c": -1.0}, "id": "VALTA", "gene_reaction_rule": "Mbar_A0576"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valyl-tRNA 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"Coenzyme ferredoxin 420-6", "notes": {"original_bigg_ids": ["f420_DASH_6_c"]}, "charge": 0, "formula": "C49H56N9O30P", "compartment": "c", "id": "f420_6_c"}, {"name": "Coenzyme ferredoxin 420-7", "notes": {"original_bigg_ids": ["f420_DASH_7_c"]}, "charge": 0, "formula": "C54H62N10O33P", "compartment": "c", "id": "f420_7_c"}, {"name": "D-Glucosamine 6-phosphate", "notes": {"original_bigg_ids": ["gam6p_c"]}, "charge": 0, "formula": "C6H13NO8P", "compartment": "c", "id": "gam6p_c"}, {"name": "Glycine", "notes": {"original_bigg_ids": ["gly_c"]}, "charge": 0, "formula": "C2H5NO2", "compartment": "c", "id": "gly_c"}, {"name": "5,10-Methylenetetrahydrofolate", "notes": {"original_bigg_ids": ["mlthf_c"]}, "charge": 0, "formula": "C20H21N7O6", "compartment": "c", "id": "mlthf_c"}, {"name": "D-Glucose", "notes": {"original_bigg_ids": ["glc_DASH_D_c"]}, "charge": 0, "formula": "C6H12O6", "compartment": "c", "id": "glc__D_c"}, {"name": "Glycogen", "notes": {"original_bigg_ids": ["glycogen_c"]}, "charge": 0, "formula": "C6H10O5", "compartment": "c", "id": "glycogen_c"}, {"name": "D-Gluconate", "notes": {"original_bigg_ids": ["glcn_c"]}, "charge": 0, "formula": "C6H11O7", "compartment": "c", "id": "glcn_c"}, {"name": "L-Glutamyl-tRNA(Gln)", "notes": {"original_bigg_ids": ["glutrna_LPAREN_gln_RPAREN__c"]}, "charge": 0, "formula": "C5H7NO3R", "compartment": "c", "id": "glutrna_gln_c"}, {"name": "L-Glutaminyl-tRNA(Gln)", "notes": {"original_bigg_ids": ["glntrna_c"]}, "charge": 0, "formula": "C5H9N2O2R", "compartment": "c", "id": "glntrna_c"}, {"name": "5-Phospho-beta-D-ribosylamine", "notes": {"original_bigg_ids": ["pram_c"]}, "charge": 0, "formula": "C5H11NO7P", "compartment": "c", "id": "pram_c"}, {"name": "TRNA (Glu)", "notes": {"original_bigg_ids": ["trnaglu_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnaglu_c"}, {"name": "L-Glutamyl-tRNA(Glu)", "notes": {"original_bigg_ids": ["glutrna_c"]}, "charge": 0, "formula": "C5H7NO3R", "compartment": "c", "id": "glutrna_c"}, {"name": "TRNA(Gln)", "notes": {"original_bigg_ids": ["trnagln_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnagln_c"}, {"name": "Glycine betaine", "notes": {"original_bigg_ids": ["glyb_c"]}, "charge": 0, "formula": "C5H11NO2", "compartment": "c", "id": "glyb_c"}, {"name": "Glycerol", "notes": {"original_bigg_ids": ["glyc_c"]}, "charge": 0, "formula": "C3H8O3", "compartment": "c", "id": "glyc_c"}, {"name": "TRNA(Gly)", "notes": {"original_bigg_ids": ["trnagly_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnagly_c"}, {"name": "Glycyl-tRNA(Gly)", "notes": {"original_bigg_ids": ["glytrna_c"]}, "charge": 0, "formula": "C2H4NOR", "compartment": "c", "id": "glytrna_c"}, {"name": "GDP-D-mannose", "notes": {"original_bigg_ids": ["gdpmann_c"]}, "charge": 0, "formula": "C16H23N5O16P2", "compartment": "c", "id": "gdpmann_c"}, {"name": "Xanthosine 5'-phosphate", "notes": {"original_bigg_ids": ["xmp_c"]}, "charge": 0, "formula": "C10H11N4O9P", "compartment": "c", "id": "xmp_c"}, {"name": "GDP-L-fucose", "notes": {"original_bigg_ids": ["gdpfuc_c"]}, "charge": 0, "formula": "C16H23N5O15P2", "compartment": "c", "id": "gdpfuc_c"}, {"name": "Reduced glutathione", "notes": {"original_bigg_ids": ["gthrd_c"]}, "charge": 0, "formula": "C10H16N3O6S", "compartment": "c", "id": "gthrd_c"}, {"name": "Oxidized glutathione", "notes": {"original_bigg_ids": ["gthox_c"]}, "charge": 0, "formula": "C20H30N6O12S2", "compartment": "c", "id": "gthox_c"}, {"name": "Triaminopyrimidine triphosphate", "notes": {"original_bigg_ids": ["ptp_c"]}, "charge": 0, "formula": "C9H14N5O14P3", "compartment": "c", "id": "ptp_c"}, {"name": "Xanthine", "notes": {"original_bigg_ids": ["xan_c"]}, "charge": 0, "formula": "C5H4N4O2", "compartment": "c", "id": "xan_c"}, {"name": "Guanine", "notes": {"original_bigg_ids": ["gua_c"]}, "charge": 0, "formula": "C5H5N5O", "compartment": "c", "id": "gua_c"}, {"name": "5,6,7,8-tetrahydromethanopterin", "notes": 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"7,8-dihydropterin-6-ylmethyl-1-(4-aminophenyl)-1-deoxy-5-[1-A-D-ribofuranosyl 5'-diphosphate]-D-ribitol", "notes": {"original_bigg_ids": ["dhadrdpr_c"]}, "charge": 0, "formula": "C23H31N6O15P2", "compartment": "c", "id": "dhadrdpr_c"}, {"name": "7,8-dihydropterin-6-ylmethyl-1-(4-aminophenyl)-1-deoxy-5-[1-A-D-ribofuranosyl 5'-triphosphate]-D-ribitol", "notes": {"original_bigg_ids": ["dhadrtpr_c"]}, "charge": 0, "formula": "C23H31N6O18P3", "compartment": "c", "id": "dhadrtpr_c"}, {"name": "Didemethylated 7,8-dihydromethanopterin", "notes": {"original_bigg_ids": ["dmh2mpt_c"]}, "charge": 0, "formula": "C28H36N6O16P", "compartment": "c", "id": "dmh2mpt_c"}, {"name": "Monomethylated 7,8-dihydromethanoterin", "notes": {"original_bigg_ids": ["mmh2mpt_c"]}, "charge": 0, "formula": "C29H38N6O16P", "compartment": "c", "id": "mmh2mpt_c"}, {"name": "2-O-(3'-hydroxy)phytanyl-3-O-phytanyl-sn-glycero-l-phosphoserine", "notes": {"original_bigg_ids": ["3hdpgps_c"]}, "charge": 0, "formula": "C46H93N1O9P1", "compartment": "c", "id": "3hdpgps_c"}, {"name": "2-O-(3'-hydroxy)phytanyl-3-O-phytanyl-sn-glycero-l-phosphoethanolamine", "notes": {"original_bigg_ids": ["3hdpgpe_c"]}, "charge": 0, "formula": "C45H94O7N1P1", "compartment": "c", "id": "3hdpgpe_c"}, {"name": "2-O-(3'-hydroxy)phytanyl-3-O-phytanyl-sn-glycerol-1-phospho-3'-sn-glycerol", "notes": {"original_bigg_ids": ["3hdpgpg_c"]}, "charge": 0, "formula": "C46H94O9P1", "compartment": "c", "id": "3hdpgpg_c"}, {"name": "2-O-(3'-hydroxyl)phytanyl-3-O-phytanyl-sn-glycero-1-phospho-myo-inositol", "notes": {"original_bigg_ids": ["3hdpgpi_c"]}, "charge": 0, "formula": "C49H98O12P1", "compartment": "c", "id": "3hdpgpi_c"}, {"name": "2 Hydroxybutane 1 2 4 tricarboxylate C7H7O7", "notes": {"original_bigg_ids": ["hcit_c"]}, "charge": 0, "formula": "C7H7O7", "compartment": "c", "id": "hcit_c"}, {"name": "Heterodisulfide", "notes": {"original_bigg_ids": ["hsfd_c"]}, "charge": 0, "formula": "C13H22N1O10P1S3", "compartment": "c", "id": "hsfd_c"}, {"name": "4-Methyl-5-(2-hydroxyethyl)-thiazole", "notes": {"original_bigg_ids": ["4mhetz_c"]}, "charge": 0, "formula": "C6H9NOS", "compartment": "c", "id": "4mhetz_c"}, {"name": "4-Methyl-5-(2-phosphoethyl)-thiazole", "notes": {"original_bigg_ids": ["4mpetz_c"]}, "charge": 0, "formula": "C6H8NO4PS", "compartment": "c", "id": "4mpetz_c"}, {"name": "D-Fructose", "notes": {"original_bigg_ids": ["fru_c"]}, "charge": 0, "formula": "C6H12O6", "compartment": "c", "id": "fru_c"}, {"name": "Hista c", "notes": {"original_bigg_ids": ["hista_c"]}, "charge": 0, "formula": "C5H10N3", "compartment": "c", "id": "hista_c"}, {"name": "L-Histidine", "notes": {"original_bigg_ids": ["his_DASH_L_c"]}, "charge": 0, "formula": "C6H9N3O2", "compartment": "c", "id": "his__L_c"}, {"name": "L-Histidinol", "notes": {"original_bigg_ids": ["histd_c"]}, "charge": 0, "formula": "C6H12N3O", "compartment": "c", "id": "histd_c"}, {"name": "L-Histidinol phosphate", "notes": {"original_bigg_ids": ["hisp_c"]}, 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C27H39N7O20P3S", "notes": {"original_bigg_ids": ["hmgcoa_c"]}, "charge": 0, "formula": "C27H39N7O20P3S", "compartment": "c", "id": "hmgcoa_c"}, {"name": "4-Amino-2-methyl-5-phosphomethylpyrimidine", "notes": {"original_bigg_ids": ["4ampm_c"]}, "charge": 0, "formula": "C6H8N3O4P", "compartment": "c", "id": "4ampm_c"}, {"name": "4-Hydroxyphenylacetate", "notes": {"original_bigg_ids": ["4hphac_c"]}, "charge": 0, "formula": "C8H7O3", "compartment": "c", "id": "4hphac_c"}, {"name": "L-Homoserine", "notes": {"original_bigg_ids": ["hom_DASH_L_c"]}, "charge": 0, "formula": "C4H9NO3", "compartment": "c", "id": "hom__L_c"}, {"name": "O-Phospho-L-homoserine", "notes": {"original_bigg_ids": ["phom_c"]}, "charge": 0, "formula": "C4H8NO6P", "compartment": "c", "id": "phom_c"}, {"name": "Sym-Homospermidine", "notes": {"original_bigg_ids": ["hspmd_c"]}, "charge": 0, "formula": "C8H24N3", "compartment": "c", "id": "hspmd_c"}, {"name": "3-(Imidazol-4-yl)-2-oxopropyl phosphate", "notes": 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"compartment": "c", "id": "ile__L_c"}, {"name": "TRNA(Ile)", "notes": {"original_bigg_ids": ["trnaile_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnaile_c"}, {"name": "L-Isoleucyl-tRNA(Ile)", "notes": {"original_bigg_ids": ["iletrna_c"]}, "charge": 0, "formula": "C6H12NOR", "compartment": "c", "id": "iletrna_c"}, {"name": "Indole 3 acetate C10H8NO2", "notes": {"original_bigg_ids": ["ind3ac_c"]}, "charge": 0, "formula": "C10H8NO2", "compartment": "c", "id": "ind3ac_c"}, {"name": "2-Inosose", "notes": {"original_bigg_ids": ["2ins_c"]}, "charge": 0, "formula": "C6H10O6", "compartment": "c", "id": "2ins_c"}, {"name": "Indolepyruvate C11H8NO3", "notes": {"original_bigg_ids": ["indpyr_c"]}, "charge": 0, "formula": "C11H8NO3", "compartment": "c", "id": "indpyr_c"}, {"name": "S-2-(indol-3-yl)acetyl-CoA", "notes": {"original_bigg_ids": ["indaccoa_c"]}, "charge": 0, "formula": "C31H39N8O17P3S", "compartment": "c", "id": "indaccoa_c"}, {"name": "Phenylacetyl-CoA", "notes": 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