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{"arbt_e": -1.0}, "id": "EX_arbt_e", "gene_reaction_rule": ""}, {"name": "Aerobactin minus Fe3 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_e": -1.0}, "id": "EX_arbtn_e", "gene_reaction_rule": ""}, {"name": "Aerobactin exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_DASH_fe3_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_fe3_e": -1.0}, "id": "EX_arbtn_fe3_e", "gene_reaction_rule": ""}, {"name": "L-Arginine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arg_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"arg__L_e": -1.0}, "id": "EX_arg__L_e", "gene_reaction_rule": ""}, {"name": "L-Ascorbate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ascb_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"ascb__L_e": -1.0}, "id": "EX_ascb__L_e", "gene_reaction_rule": ""}, {"name": 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"Fe(III)hydroxamate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_e": -1.0}, "id": "EX_fe3hox_e", "gene_reaction_rule": ""}, {"name": "Fe(III)hydoxamate, unloaded exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_un_e": -1.0}, "id": "EX_fe3hox_un_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_e": -1.0}, "id": "EX_fecrm_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome minus Fe(III) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_un_e": -1.0}, "id": "EX_fecrm_un_e", "gene_reaction_rule": ""}, {"name": "Fe-enterobactin exchange", "upper_bound": 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["EX_lcts_LPAREN_e_RPAREN_"]}, "metabolites": {"lcts_e": -1.0}, "id": "EX_lcts_e", "gene_reaction_rule": ""}, {"name": "L-Leucine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_leu_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"leu__L_e": -1.0}, "id": "EX_leu__L_e", "gene_reaction_rule": ""}, {"name": "KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_e": -1.0}, "id": "EX_lipa_e", "gene_reaction_rule": ""}, {"name": "Cold adapted KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_cold_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_cold_e": -1.0}, "id": "EX_lipa_cold_e", "gene_reaction_rule": ""}, {"name": "Lipoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipoate_LPAREN_e_RPAREN_"]}, "metabolites": {"lipoate_e": -1.0}, "id": 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"notes": {"original_bigg_ids": ["23CUMPtex"]}, "metabolites": {"23cump_p": 1.0, "23cump_e": -1.0}, "id": "23CUMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "2,3-diaminopropionate transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23DAPPAt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "23dappa_c": 1.0, "23dappa_p": -1.0}, "id": "23DAPPAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2,3-diaminopropionate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23DAPPAtex"]}, "metabolites": {"23dappa_e": -1.0, "23dappa_p": 1.0}, "id": "23DAPPAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (UMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, 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"2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA161tipp"]}, "metabolites": {"2hdec9eg3p_c": 1.0, "2hdec9eg3p_p": -1.0}, "id": "2AGPA161tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA180tipp"]}, "metabolites": {"2odecg3p_p": -1.0, "2odecg3p_c": 1.0}, "id": "2AGPA180tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA181tipp"]}, "metabolites": {"2odec11eg3p_p": -1.0, "2odec11eg3p_c": 1.0}, "id": "2AGPA181tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE120tipp"]}, "metabolites": {"2agpe120_p": -1.0, "2agpe120_c": 1.0}, "id": "2AGPE120tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE140tipp"]}, "metabolites": {"2agpe140_c": 1.0, "2agpe140_p": -1.0}, "id": "2AGPE140tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE141tipp"]}, 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"2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT140"]}, "metabolites": {"atp_c": -1.0, "pe140_c": 1.0, "ppi_c": 1.0, "2agpe140_c": -1.0, "amp_c": 1.0, "ttdca_c": -1.0}, "id": "2AGPEAT140", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT141"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ttdcea_c": -1.0, "pe141_c": 1.0, "2agpe141_c": -1.0}, "id": "2AGPEAT141", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT160"]}, "metabolites": {"2agpe160_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "hdca_c": 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(n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG141tipp"]}, "metabolites": {"2agpg141_p": -1.0, "2agpg141_c": 1.0}, "id": "2AGPG141tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG160tipp"]}, "metabolites": {"2agpg160_c": 1.0, "2agpg160_p": -1.0}, "id": "2AGPG160tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG161tipp"]}, "metabolites": {"2agpg161_c": 1.0, "2agpg161_p": -1.0}, "id": "2AGPG161tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG180tipp"]}, "metabolites": {"2agpg180_p": -1.0, "2agpg180_c": 1.0}, "id": "2AGPG180tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG181tipp"]}, "metabolites": {"2agpg181_p": -1.0, "2agpg181_c": 1.0}, "id": "2AGPG181tipp", "gene_reaction_rule": "b2835"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT120"]}, "metabolites": {"atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg120_c": 1.0, "2agpg120_c": -1.0}, 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["2AGPGAT160"]}, "metabolites": {"2agpg160_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg160_c": 1.0, "hdca_c": -1.0}, "id": "2AGPGAT160", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT161"]}, "metabolites": {"atp_c": -1.0, "2agpg161_c": -1.0, "ppi_c": 1.0, "hdcea_c": -1.0, "pg161_c": 1.0, "amp_c": 1.0}, "id": "2AGPGAT161", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT180"]}, "metabolites": {"pg180_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ocdca_c": -1.0, "2agpg180_c": -1.0}, "id": "2AGPGAT180", "gene_reaction_rule": "b2836"}, {"subsystem": "Glycerophospholipid Metabolism", "name": 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"Transport, Outer Membrane Porin", "name": "3UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3UMPtex"]}, "metabolites": {"3ump_e": -1.0, "3ump_p": 1.0}, "id": "3UMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Nitrogen Metabolism", "name": "4-(2-Aminoethyl)-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["42A12BOOXpp"]}, "metabolites": {"h2o2_p": 1.0, "34dhpac_p": 1.0, "nh4_p": 1.0, "h2o_p": -1.0, "o2_p": -1.0, "dopa_p": -1.0}, "id": "42A12BOOXpp", "gene_reaction_rule": "b1386"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HOXPACDtex"]}, "metabolites": {"4hoxpacd_p": 1.0, "4hoxpacd_e": -1.0}, "id": "4HOXPACDtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-Hydroxy-L-threonine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HTHRS"]}, "metabolites": {"phthr_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "4hthr_c": 1.0}, "id": "4HTHRS", "gene_reaction_rule": "b0004"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "LalaDgluMdapDala_c": -1.0, "LalaDgluMdap_c": 1.0}, "id": "4PCP", "gene_reaction_rule": "b1192"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCPpp"]}, "metabolites": {"LalaDgluMdapDala_p": -1.0, "h2o_p": -1.0, "LalaDgluMdap_p": 1.0, "ala__D_p": 1.0}, "id": "4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide (LalaDgluMdapDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "LalaDgluMdapDala_c": 1.0, "LalaDgluMdapDala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "4PEPTabcpp", "gene_reaction_rule": "b1243 and b1244 and b1245 and b1246 and b1247"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "LalaDgluMdapDala (pentapeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4PEPTtex"]}, "metabolites": {"LalaDgluMdapDala_p": 1.0, "LalaDgluMdapDala_e": -1.0}, "id": "4PEPTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "5-dehydro-D-gluconate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNR"]}, "metabolites": {"glcn_c": 1.0, "5dglcn_c": -1.0, "nadph_c": -1.0, "h_c": -1.0, "nadp_c": 1.0}, "id": "5DGLCNR", "gene_reaction_rule": "b4266"}, {"subsystem": "Transport, Inner Membrane", "name": "5-Dehydro-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNt2rpp"]}, "metabolites": {"5dglcn_p": -1.0, "5dglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "5DGLCNt2rpp", "gene_reaction_rule": "b4265"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Dehydro-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNtex"]}, "metabolites": {"5dglcn_p": 1.0, "5dglcn_e": -1.0}, "id": "5DGLCNtex", "gene_reaction_rule": "b0241 or b0929 or b2215 or b1377"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "5'-deoxyadenosine nuclosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5DOAN"]}, "metabolites": {"dad_5_c": -1.0, "ade_c": 1.0, "h2o_c": -1.0, "5drib_c": 1.0}, "id": "5DOAN", "gene_reaction_rule": "b0159"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Methylthio-D-ribose transport via proton diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5MTRtex"]}, "metabolites": {"5mtr_e": -1.0, "5mtr_p": 1.0}, "id": "5MTRtex", "gene_reaction_rule": "b1377 or b0929 or b2215 or b0241"}, {"subsystem": "Transport, Inner Membrane", "name": "5-Methylthio-D-ribose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5MTRtpp"]}, "metabolites": {"5mtr_c": -1.0, "h_c": -1.0, "h_p": 1.0, "5mtr_p": 1.0}, "id": "5MTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arabinose-5-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["A5PISO"]}, "metabolites": {"ara5p_c": 1.0, "ru5p__D_c": -1.0}, "id": "A5PISO", "gene_reaction_rule": "b3197 or b2708"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS1"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "myrsACP_c": 1.0, "ttdca_c": -1.0}, "id": "AACPS1", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS2"]}, "metabolites": {"atp_c": -1.0, "tdeACP_c": 1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ttdcea_c": -1.0}, "id": "AACPS2", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS3"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "palmACP_c": 1.0, "hdca_c": -1.0}, "id": "AACPS3", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS4"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "hdcea_c": -1.0, "amp_c": 1.0, "hdeACP_c": 1.0}, "id": "AACPS4", "gene_reaction_rule": "b2836 and b1094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS5"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "octeACP_c": 1.0}, "id": "AACPS5", "gene_reaction_rule": "b2836 and b1094"}, 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"Arginine and Proline Metabolism", "name": "4-aminobutyrate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "sucsal_c": 1.0, "4abut_c": -1.0}, "id": "ABTA", "gene_reaction_rule": "b2662 or b1302"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminobutyraldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTD"]}, "metabolites": {"h2o_c": -1.0, "4abutn_c": -1.0, "4abut_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ABUTD", "gene_reaction_rule": "b1444"}, {"subsystem": "Transport, Inner Membrane", "name": "4-aminobutyrate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTt2pp"]}, "metabolites": {"4abut_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4abut_c": 1.0}, "id": "ABUTt2pp", "gene_reaction_rule": "b2663"}, {"subsystem": "Transport, Outer Membrane 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C-acyltransferase (butanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT2r"]}, "metabolites": {"btcoa_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "3ohcoa_c": 1.0}, "id": "ACACT2r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT3r"]}, "metabolites": {"coa_c": 1.0, "accoa_c": -1.0, "3oocoa_c": 1.0, "hxcoa_c": -1.0}, "id": "ACACT3r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT4r"]}, "metabolites": {"coa_c": 1.0, "3odcoa_c": 1.0, "occoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT4r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT5r"]}, "metabolites": {"3oddcoa_c": 1.0, "coa_c": 1.0, "dcacoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT5r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT6r"]}, "metabolites": {"ddcacoa_c": -1.0, "3otdcoa_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT6r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT7r"]}, "metabolites": {"coa_c": 1.0, "tdcoa_c": -1.0, "3ohdcoa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT7r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT8r"]}, "metabolites": {"pmtcoa_c": 1.0, "3oodcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "ACACT8r", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetoacetate transport via proton symport  (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACt2pp"]}, "metabolites": {"acac_c": 1.0, "acac_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ACACt2pp", "gene_reaction_rule": "b2223"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetoacetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACtex"]}, "metabolites": {"acac_p": 1.0, "acac_e": -1.0}, "id": "ACACtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetaldehyde dehydrogenase (acetylating)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALD"]}, "metabolites": {"accoa_c": 1.0, "acald_c": -1.0, "coa_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ACALD", "gene_reaction_rule": "b0351 or b1241"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDtex"]}, "metabolites": {"acald_p": 1.0, "acald_e": -1.0}, "id": "ACALDtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetaldehyde reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDtpp"]}, "metabolites": {"acald_c": 1.0, "acald_p": -1.0}, "id": "ACALDtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Acetyl-CoA:anthranilate acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACANTHAT"]}, "metabolites": {"anth_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "acanth_c": 1.0}, "id": "ACANTHAT", "gene_reaction_rule": "b1463"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide phosphate guanyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACBIPGT"]}, "metabolites": {"adocbip_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "agdpcbi_c": 1.0}, "id": "ACBIPGT", "gene_reaction_rule": "b1993"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAC"]}, "metabolites": {"malcoa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "pi_c": 1.0}, "id": "ACCOAC", "gene_reaction_rule": "b0185 and b2316 and b3255 and b3256"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetate-CoA ligase (ADP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAL"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "ppa_c": -1.0, "coa_c": -1.0, "ppcoa_c": 1.0, "pi_c": 1.0}, "id": "ACCOAL", "gene_reaction_rule": "b4069"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-galactosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgal_p": 1.0, "acgal1p_p": -1.0}, "id": "ACGAL1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAL1Ptex"]}, "metabolites": {"acgal1p_p": 1.0, "acgal1p_e": -1.0}, "id": "ACGAL1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGALtex"]}, "metabolites": {"acgal_p": 1.0, "acgal_e": -1.0}, "id": "ACGALtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-glucosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAM1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgam_p": 1.0, "acgam1p_p": -1.0}, "id": "ACGAM1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-glucosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAM1Ptex"]}, "metabolites": {"acgam1p_e": -1.0, "acgam1p_p": 1.0}, "id": "ACGAM1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Murein Recycling", "name": "N-acetylglucosamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMK"]}, "metabolites": {"acgam_c": -1.0, "acgam6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ACGAMK", "gene_reaction_rule": "b1119"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMT"]}, "metabolites": {"uacgam_c": -1.0, "ump_c": 1.0, "unaga_c": 1.0, "udcpp_c": -1.0}, "id": "ACGAMT", "gene_reaction_rule": "b3784"}, {"subsystem": "Transport, Inner Membrane", "name": "N-Acetyl-D-glucosamine transport via PEP:Pyr PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAptspp"]}, 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["ACLS"]}, "metabolites": {"pyr_c": -2.0, "co2_c": 1.0, "h_c": -1.0, "alac__S_c": 1.0}, "id": "ACLS", "gene_reaction_rule": "(b3670 and b3671) or (b0077 and b0078)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmuramate 6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACM6PH"]}, "metabolites": {"acgam6p_c": 1.0, "acmum6p_c": -1.0, "lac__D_c": 1.0, "h2o_c": -1.0}, "id": "ACM6PH", "gene_reaction_rule": "b2428"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetyl-D-mannosaminuronic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMAMUT"]}, "metabolites": {"udp_c": 1.0, "unagamu_c": 1.0, "h_c": 1.0, "uacmamu_c": -1.0, "unaga_c": -1.0}, "id": "ACMAMUT", "gene_reaction_rule": "b3794"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetyl-D-mannosamine transport via PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"N-acetylmuramate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMUMtex"]}, "metabolites": {"acmum_e": -1.0, "acmum_p": 1.0}, "id": "ACMUMtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetylneuraminate proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNAMt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "acnam_p": -1.0, "acnam_c": 1.0}, "id": "ACNAMt2pp", "gene_reaction_rule": "b3224"}, {"subsystem": "Transport, Outer Membrane", "name": "N-acetylneuraminate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACNAMtex"]}, "metabolites": {"acnam_e": -1.0, "acnam_p": 1.0}, "id": "ACNAMtex", "gene_reaction_rule": "b4311 or b0929 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-Acetylneuraminate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNML"]}, "metabolites": {"pyr_c": 1.0, "acmana_c": 1.0, "acnam_c": -1.0}, "id": "ACNML", "gene_reaction_rule": "b3225"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (butanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD1f"]}, "metabolites": {"btcoa_c": -1.0, "b2coa_c": 1.0, "fadh2_c": 1.0, "fad_c": -1.0}, "id": "ACOAD1f", "gene_reaction_rule": "b0221"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD2f"]}, "metabolites": {"fadh2_c": 1.0, "fad_c": -1.0, "hxcoa_c": -1.0, "hx2coa_c": 1.0}, "id": "ACOAD2f", "gene_reaction_rule": "b0221"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, 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1.0, "h2o_c": -1.0, "urea_c": 1.0, "agm_c": -1.0}, "id": "AGMT", "gene_reaction_rule": "b2937"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMt2pp"]}, "metabolites": {"h_c": 1.0, "anhgm_p": -1.0, "h_p": -1.0, "anhgm_c": 1.0}, "id": "AGMt2pp", "gene_reaction_rule": "b0433"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Agmatine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGMtex"]}, "metabolites": {"agm_p": 1.0, "agm_e": -1.0}, "id": "AGMtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT120"]}, "metabolites": {"1ddecg3p_c": -1.0, "ACP_c": 1.0, "pa120_c": 1.0, "ddcaACP_c": -1.0}, "id": "AGPAT120", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT140"]}, "metabolites": {"1tdecg3p_c": -1.0, "pa140_c": 1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "AGPAT140", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT141"]}, "metabolites": {"tdeACP_c": -1.0, "pa141_c": 1.0, "ACP_c": 1.0, "1tdec7eg3p_c": -1.0}, "id": "AGPAT141", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT160"]}, "metabolites": {"pa160_c": 1.0, "ACP_c": 1.0, "1hdecg3p_c": -1.0, "palmACP_c": -1.0}, "id": "AGPAT160", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT161"]}, "metabolites": {"pa161_c": 1.0, "1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "b3018"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "b3018"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "b3958"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Silver transport out via proton antiport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGt3"]}, "metabolites": {"ag_e": 1.0, "h_e": -1.0, "h_c": 1.0, "ag_c": -1.0}, "id": "AGt3", "gene_reaction_rule": "b0572 and b0573 and b0574 and b0575"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"rhcys_c": 1.0, "h2o_c": -1.0, "ahcys_c": -1.0, "ade_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "b0159"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "10fthf_c": -1.0, "thf_c": 1.0}, "id": "AICART", "gene_reaction_rule": "b4006"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "b0522"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "b0523"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "b0116 and b0726 and b0727"}, {"subsystem": "Transport, Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": "b2587"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Murein Recycling", "name": "D-alanine-D-alanine dipeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAD"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 2.0, "alaala_c": -1.0}, "id": "ALAALAD", "gene_reaction_rule": "b1488"}, {"subsystem": "Transport, Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "(b1487 and b1486 and b1485 and b1484 and b1483) or (b3544 and b3543 and b3542 and b3541 and b3540)"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "b0381 or b0092"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaDglu_c": -1.0, "LalaLglu_c": 1.0}, "id": "ALAGLUE", "gene_reaction_rule": "b1325"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": "b1190 or b4053"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"pydx5p_c": -1.0, "pyr_c": 1.0, "ala__D_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "b2551 or b0870"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-alanine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "glu__L_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "b2290 or b2379"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_L2"]}, "metabolites": {"ala__L_c": -1.0, "pyr_c": 1.0, "pydx5p_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_L2", "gene_reaction_rule": "b0870 or b2551"}, {"subsystem": "tRNA Charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "b2697"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ala__L_p": -1.0}, "id": "ALAabcpp", "gene_reaction_rule": "b3454 and b3455 and b3457 and b3460 and b3456"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy1", "gene_reaction_rule": "b4208"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "b0007"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"glyald_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "glyc_c": 1.0}, "id": "ALCD19", "gene_reaction_rule": "b0356"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "etoh_c": -1.0}, "id": "ALCD2x", "gene_reaction_rule": "b1478 or b1241 or b0356"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (phenylacetaldehyde, NAD)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALDD19xr"]}, "metabolites": {"h2o_c": -1.0, "pac_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "pacald_c": -1.0, "nadh_c": 1.0}, "id": "ALDD19xr", "gene_reaction_rule": "b1385"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2x"]}, "metabolites": {"h2o_c": -1.0, "acald_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "ac_c": 1.0, "nadh_c": 1.0}, "id": "ALDD2x", "gene_reaction_rule": "b1300"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "acald_c": -1.0, "h_c": 2.0, "ac_c": 1.0}, "id": "ALDD2y", "gene_reaction_rule": "b3588"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (propanal, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD3y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "ppa_c": 1.0, "ppal_c": -1.0, "h_c": 2.0}, "id": "ALDD3y", "gene_reaction_rule": "b3588"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (butanal, NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD4"]}, "metabolites": {"h2o_c": -1.0, "btal_c": -1.0, "but_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ALDD4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLK"]}, "metabolites": {"all6p_c": 1.0, "all__D_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ALLK", "gene_reaction_rule": "b4084"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose 6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLPI"]}, "metabolites": {"all6p_c": -1.0, "allul6p_c": 1.0}, "id": "ALLPI", "gene_reaction_rule": "b4090"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allantoate amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTAMH"]}, "metabolites": {"alltt_c": -1.0, "urdglyc_c": 1.0, "h2o_c": -2.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "ALLTAMH", "gene_reaction_rule": "b0516"}, {"subsystem": "Nitrogen Metabolism", "name": "Allantoinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTN"]}, "metabolites": {"alltt_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "alltn_c": -1.0}, "id": "ALLTN", "gene_reaction_rule": "b0512"}, {"subsystem": "Transport, Inner Membrane", "name": "Allantoin transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, 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"id": "CDGR", "gene_reaction_rule": "b2794"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-deaza-7-carboxyguanine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDGS"]}, "metabolites": {"cdg_c": 1.0, "cph4_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "CDGS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPMEK"]}, "metabolites": {"2p4c2me_c": 1.0, "4c2me_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "CDPMEK", "gene_reaction_rule": "b1208"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS160E"]}, "metabolites": {"amet_c": -2.0, "cpe160_c": 1.0, "pe161_c": -1.0, "h_c": 2.0, "ahcys_c": 2.0}, "id": "CFAS160E", "gene_reaction_rule": "b1661"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS160G"]}, "metabolites": {"amet_c": -2.0, "pg161_c": -1.0, "ahcys_c": 2.0, "h_c": 2.0, "cpg160_c": 1.0}, "id": "CFAS160G", "gene_reaction_rule": "b1661"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180E"]}, "metabolites": {"cpe180_c": 1.0, "pe181_c": -1.0, "ahcys_c": 2.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS180E", "gene_reaction_rule": "b1661"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180G"]}, "metabolites": {"amet_c": -2.0, "cpg180_c": 1.0, "ahcys_c": 2.0, "pg181_c": -1.0, "h_c": 2.0}, "id": "CFAS180G", "gene_reaction_rule": "b1661"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Cysteinylglycine (Cys-Gly) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CGLYabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cgly_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cgly_c": 1.0}, "id": "CGLYabcpp", "gene_reaction_rule": "b3544 and b3543 and b3542 and b3541 and b3540"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Cysteinylglycine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CGLYtex"]}, "metabolites": {"cgly_e": -1.0, "cgly_p": 1.0}, "id": "CGLYtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Choline transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHLabcpp"]}, "metabolites": {"h2o_c": -1.0, "chol_p": -1.0, "atp_c": -1.0, "chol_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CHLabcpp", "gene_reaction_rule": "b2128 and b2129 and b2130 and b2131"}, {"subsystem": "Transport, Inner Membrane", "name": "Choline transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHLt2pp"]}, "metabolites": {"chol_c": 1.0, "chol_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CHLt2pp", "gene_reaction_rule": "b0314 or b1801"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Choline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CHLtex"]}, "metabolites": {"chol_p": 1.0, "chol_e": -1.0}, "id": "CHLtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Unassigned", "name": "Choline dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHOLD"]}, "metabolites": {"chol_c": -1.0, "nadh_c": 1.0, "betald_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "CHOLD", "gene_reaction_rule": "b0311"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORM"]}, "metabolites": {"chor_c": -1.0, "pphn_c": 1.0}, "id": "CHORM", "gene_reaction_rule": "b2599 or b2600"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORS"]}, "metabolites": {"chor_c": 1.0, "pi_c": 1.0, "3psme_c": -1.0}, "id": "CHORS", "gene_reaction_rule": "b2329"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Chorismate pyruvate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"succ_c": -1.0, "cit_p": -1.0, "cit_c": 1.0}, "id": "CITt7pp", "gene_reaction_rule": "b0612"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Citrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CITtex"]}, "metabolites": {"cit_e": -1.0, "cit_p": 1.0}, "id": "CITtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Cold lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLIPAabctex"]}, "metabolites": {"lipa_cold_e": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": -1.0, "pi_c": 1.0}, "id": "CLIPAabctex", "gene_reaction_rule": "b3200 and b3201 and b3199 and b4261 and b4262"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C12:0)", "upper_bound": 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n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH181pp"]}, "metabolites": {"h2o_p": -1.0, "pg181_p": 1.0, "pa181_p": 1.0, "h_p": 1.0, "clpn181_p": -1.0}, "id": "CLPNH181pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C12:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS120pp"]}, "metabolites": {"pg120_p": -2.0, "clpn120_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS120pp", "gene_reaction_rule": "b0789 or b1249"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS140pp"]}, "metabolites": {"clpn140_p": 1.0, "pg140_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS140pp", "gene_reaction_rule": "b1249 or b0789"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:1)", 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(Demethylmenaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR2pp"]}, "metabolites": {"dms_p": 1.0, "dmso_p": -1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0, "h2o_p": 1.0}, "id": "DMSOR2pp", "gene_reaction_rule": "b1872 and b1873"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dimethyl sulfoxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtex"]}, "metabolites": {"dmso_p": 1.0, "dmso_e": -1.0}, "id": "DMSOtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Dimethyl sulfoxide transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtpp"]}, "metabolites": {"dmso_p": -1.0, "dmso_c": 1.0}, "id": "DMSOtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dimethyl 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Membrane", "name": "Doxorubicin transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DOXRBCNtpp"]}, "metabolites": {"doxrbcn_e": 1.0, "h_p": -1.0, "doxrbcn_p": -1.0, "h_c": 1.0}, "id": "DOXRBCNtpp", "gene_reaction_rule": "(b0463 and b0462 and b3035) or (b0463 and b2470 and b3035)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dephospho-CoA kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPCOAK"]}, "metabolites": {"dpcoa_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DPCOAK", "gene_reaction_rule": "b0103"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-dehydropantoate 2-reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPR"]}, "metabolites": {"pant__R_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhp_c": -1.0}, "id": "DPR", "gene_reaction_rule": "b0425 or b3774"}, {"subsystem": 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{"subsystem": "Transport, Inner Membrane", "name": "Ethanol reversible transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtrpp"]}, "metabolites": {"etoh_p": -1.0, "etoh_c": 1.0}, "id": "ETOHtrpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose 6-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6PA"]}, "metabolites": {"g3p_c": 1.0, "dha_c": 1.0, "f6p_c": -1.0}, "id": "F6PA", "gene_reaction_rule": "b0825 or b3946"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-fructose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "fru_c": 1.0, "f6p_c": -1.0}, "id": "F6PP", "gene_reaction_rule": "b0822"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose-6-phosphate transport via phosphate antiport 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{"subsystem": "Cell Envelope Biosynthesis", "name": "Glucose-1-phosphate thymidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PTT"]}, "metabolites": {"dtdpglu_c": 1.0, "ppi_c": 1.0, "dttp_c": -1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "G1PTT", "gene_reaction_rule": "b2039 or b3789"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucose 1-phosphate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1Ptex"]}, "metabolites": {"g1p_e": -1.0, "g1p_p": 1.0}, "id": "G1Ptex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamate-1-semialdehyde aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1SAT"]}, "metabolites": {"5aop_c": 1.0, "glu1sa_c": -1.0}, "id": "G1SAT", "gene_reaction_rule": "b0154"}, {"subsystem": "Alternate Carbon Metabolism", 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"Glycerol-3-phosphate acyltransferase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT161"]}, "metabolites": {"1hdec9eg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "G3PAT161", "gene_reaction_rule": "b1094 and b4041"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT180"]}, "metabolites": {"glyc3p_c": -1.0, "ACP_c": 1.0, "ocdcaACP_c": -1.0, "1odecg3p_c": 1.0}, "id": "G3PAT180", "gene_reaction_rule": "b1094 and b4041"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT181"]}, "metabolites": {"1odec11eg3p_c": 1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "glyc3p_c": -1.0}, "id": "G3PAT181", "gene_reaction_rule": "b1094 and b4041"}, {"subsystem": "Transport, Inner 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-1.0, "gmp_c": 1.0, "man1p_c": 1.0, "h_c": 2.0, "gdpmann_c": -1.0}, "id": "GDPMNP", "gene_reaction_rule": "b2467"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPTPDP"]}, "metabolites": {"h2o_c": -1.0, "ppi_c": 1.0, "gtp_c": 1.0, "gdptp_c": -1.0}, "id": "GDPTPDP", "gene_reaction_rule": "b3650"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GDP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GDPtex"]}, "metabolites": {"gdp_e": -1.0, "gdp_p": 1.0}, "id": "GDPtex", "gene_reaction_rule": "b1377 or b2215 or b0929 or b0241"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamine-fructose-6-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GF6PTA"]}, "metabolites": 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{"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTt4pp"]}, "metabolites": {"glyclt_p": -1.0, "na1_p": -1.0, "glyclt_c": 1.0, "na1_c": 1.0}, "id": "GLYCLTt4pp", "gene_reaction_rule": "b4067"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycolate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTtex"]}, "metabolites": {"glyclt_p": 1.0, "glyclt_e": -1.0}, "id": "GLYCLTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO2"]}, "metabolites": {"q8h2_c": 1.0, "glyclt_c": -1.0, "glx_c": 1.0, "q8_c": -1.0}, "id": "GLYCTO2", "gene_reaction_rule": "b2979 and b4467 and b4468"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO3"]}, "metabolites": {"mqn8_c": -1.0, "glyclt_c": -1.0, "glx_c": 1.0, "mql8_c": 1.0}, "id": "GLYCTO3", "gene_reaction_rule": "b2979 and b4467 and b4468"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO4"]}, "metabolites": {"glyclt_c": -1.0, "glx_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "GLYCTO4", "gene_reaction_rule": "b2979 and b4467 and b4468"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtex"]}, "metabolites": {"glyc_e": -1.0, "glyc_p": 1.0}, "id": "GLYCtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", 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-1.0, "gua_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GUAt2pp", "gene_reaction_rule": "b3654"}, {"subsystem": "Transport, Outer Membrane", "name": "Guanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtex"]}, "metabolites": {"gua_p": 1.0, "gua_e": -1.0}, "id": "GUAtex", "gene_reaction_rule": "b0411"}, {"subsystem": "Transport, Inner Membrane", "name": "Guanine transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtpp"]}, "metabolites": {"gua_p": -1.0, "gua_c": 1.0}, "id": "GUAtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate isomerase (D-glucuronate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI1"]}, "metabolites": {"glcur_c": -1.0, "fruur_c": 1.0}, "id": "GUI1", "gene_reaction_rule": "b3092"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate isomerase (D-galacturonate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI2"]}, "metabolites": {"tagur_c": 1.0, "galur_c": -1.0}, "id": "GUI2", "gene_reaction_rule": "b3092"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate 1-phosphate phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUR1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glcur1p_p": -1.0, "glcur_p": 1.0}, "id": "GUR1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hydrogen peroxide transport via diffusion (external)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2O2tex"]}, "metabolites": {"h2o2_p": 1.0, "h2o2_e": -1.0}, "id": "H2O2tex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "H2O transport via diffusion (extracellular to periplasm)", 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"gene_reaction_rule": "s0001"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD1"]}, "metabolites": {"aacoa_c": -1.0, "3hbcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD1", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD2"]}, "metabolites": {"3hhcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "3ohcoa_c": -1.0}, "id": "HACD2", "gene_reaction_rule": "b3846 or b2341"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD3"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "nad_c": 1.0, "3oocoa_c": -1.0, 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1.0, "glu__L_c": 1.0, "eig3p_c": 1.0, "h_c": 1.0, "prlp_c": -1.0, "gln__L_c": -1.0}, "id": "IG3PS", "gene_reaction_rule": "b2023 and b2025"}, {"subsystem": "Histidine Metabolism", "name": "Imidazoleglycerol-phosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPDH"]}, "metabolites": {"h2o_c": 1.0, "imacp_c": 1.0, "eig3p_c": -1.0}, "id": "IGPDH", "gene_reaction_rule": "b2022"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Indole-3-glycerol-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPS"]}, "metabolites": {"h2o_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "2cpr5p_c": -1.0, "3ig3p_c": 1.0}, "id": "IGPS", "gene_reaction_rule": "b1262"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Isoleucine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILETA"]}, "metabolites": {"akg_c": -1.0, "ile__L_c": -1.0, 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["ILEt2rpp"]}, "metabolites": {"ile__L_c": 1.0, "ile__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ILEt2rpp", "gene_reaction_rule": "b0401"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-isoleucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEtex"]}, "metabolites": {"ile__L_p": 1.0, "ile__L_e": -1.0}, "id": "ILEtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "b4006"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMPD"]}, "metabolites": {"xmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "imp_c": -1.0}, "id": "IMPD", "gene_reaction_rule": "b2508"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "IMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPtex"]}, "metabolites": {"imp_e": -1.0, "imp_p": 1.0}, "id": "IMPtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, irreversible (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INDOLEt2pp"]}, "metabolites": {"h_p": 1.0, "indole_c": -1.0, "indole_p": 1.0, "h_c": -1.0}, "id": "INDOLEt2pp", "gene_reaction_rule": "(b3265 and b3266) and b3035"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEt2rpp"]}, "metabolites": {"indole_p": -1.0, "h_c": 1.0, "h_p": -1.0, "indole_c": 1.0}, "id": "INDOLEt2rpp", "gene_reaction_rule": "b3161"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Indole transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEtex"]}, "metabolites": {"indole_e": -1.0, "indole_p": 1.0}, "id": "INDOLEtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/myo-inositol symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INOSTt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "inost_c": 1.0, "inost_p": -1.0}, "id": "INOSTt4pp", "gene_reaction_rule": "b3679"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Inosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSH"]}, "metabolites": {"h2o_c": -1.0, "hxan_c": 1.0, "rib__D_c": 1.0, "ins_c": -1.0}, "id": "INSH", "gene_reaction_rule": "b0030"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Insosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSK"]}, "metabolites": {"adp_c": 1.0, "imp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "ins_c": -1.0}, "id": "INSK", "gene_reaction_rule": "b0477"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy1", 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"Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate hydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIb"]}, "metabolites": {"2ippm_c": -1.0, "h2o_c": -1.0, "3c3hmp_c": 1.0}, "id": "IPPMIb", "gene_reaction_rule": "b0071 and b0072"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPPS"]}, "metabolites": {"h2o_c": -1.0, "accoa_c": -1.0, "3mob_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "3c3hmp_c": 1.0}, "id": "IPPS", "gene_reaction_rule": "b0074"}, {"subsystem": "Transport, Inner Membrane", "name": "Isethionate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ISETACabcpp"]}, "metabolites": {"isetac_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "isetac_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ISETACabcpp", "gene_reaction_rule": 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"Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "b2323 or b1095"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "b1091"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "b0918"}, {"subsystem": 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{"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "(b0698 and b0697 and b0696) or (b0698 and b0697 and b0696 and b4513)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "(b1291 and b3290 and b3849) or b1250 or (b1291 and b3290 and b1363) or b3747"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LA4NTpp"]}, "metabolites": {"colipa_p": -1.0, "udcpp_p": 1.0, "acolipa_p": 1.0, "uLa4n_p": -1.0}, "id": "LA4NTpp", "gene_reaction_rule": "b2257"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZ"]}, "metabolites": {"lcts_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "gal_c": 1.0}, "id": "LACZ", "gene_reaction_rule": "b0344"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZpp"]}, "metabolites": {"gal_p": 1.0, "h2o_p": -1.0, "lcts_p": -1.0, "glc__D_p": 1.0}, "id": "LACZpp", "gene_reaction_rule": "b2132"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LADGMDH"]}, "metabolites": {"LalaDglu_c": 1.0, "h2o_c": -1.0, "26dap__M_c": 1.0, "LalaDgluMdap_c": -1.0}, "id": "LADGMDH", "gene_reaction_rule": "b1326"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-D-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALADGLUtex"]}, "metabolites": {"LalaDglu_p": 1.0, "LalaDglu_e": -1.0}, "id": "LALADGLUtex", "gene_reaction_rule": "b2215 or b1377 or b0241 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-D-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALADGLUtpp"]}, "metabolites": {"LalaDglu_p": -1.0, "LalaDglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALADGLUtpp", "gene_reaction_rule": "b1634 or b3496 or b4130 or b0709"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALALGLUtex"]}, "metabolites": {"LalaLglu_p": 1.0, "LalaLglu_e": -1.0}, "id": "LALALGLUtex", "gene_reaction_rule": "b2215 or b1377 or b0241 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-L-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALALGLUtpp"]}, "metabolites": {"LalaLglu_p": -1.0, "LalaLglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALALGLUtpp", "gene_reaction_rule": "b1634 or b3496 or b4130 or b0709"}, {"subsystem": "Methylglyoxal Metabolism", "name": "D-Lactaldehyde:NAD+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO2x"]}, "metabolites": {"mthgxl_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "lald__D_c": 1.0}, "id": "LALDO2x", "gene_reaction_rule": "b3945"}, {"subsystem": "Methylglyoxal Metabolism", "name": "L-Lactaldehyde:NADP+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO3"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "lald__L_c": 1.0, "mthgxl_c": -1.0}, "id": "LALDO3", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"h2o_c": -1.0, "ala__L_c": 1.0, "glu__L_c": 1.0, "LalaLglu_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "b0237"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lactaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCADi"]}, "metabolites": {"h2o_c": -1.0, "lald__L_c": -1.0, "lac__L_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "LCADi", "gene_reaction_rule": "b1415"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"lald__D_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "12ppd__R_c": 1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "12ppd__S_c": 1.0, "h_c": -1.0, "lald__L_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "b2799"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton aniport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCTSt3ipp"]}, "metabolites": {"lcts_c": -1.0, "lcts_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTSt3ipp", "gene_reaction_rule": "b2170 or b0070 or b1528"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStpp"]}, "metabolites": {"lcts_c": 1.0, "lcts_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTStpp", "gene_reaction_rule": "b0343"}, {"subsystem": "Pyruvate Metabolism", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LDH_D"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "lac__D_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "LDH_D", "gene_reaction_rule": "b2133 or b1380"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LDH_D2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__D_c": -1.0, "q8_c": -1.0}, "id": "LDH_D2", "gene_reaction_rule": "b2133"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Leucine transaminase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTAi"]}, "metabolites": {"akg_c": 1.0, "leu__L_c": 1.0, "4mop_c": -1.0, "glu__L_c": -1.0}, "id": "LEUTAi", "gene_reaction_rule": "b3770 or b4054"}, {"subsystem": "tRNA Charging", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "b0642"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "leu__L_c": 1.0, "leu__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LEUabcpp", "gene_reaction_rule": "(b3454 and b3455 and b3457 and b3460 and b3456) or (b3454 and b3455 and b3457 and b3458 and b3456)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUt2rpp"]}, "metabolites": {"leu__L_p": -1.0, "leu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LEUt2rpp", "gene_reaction_rule": "b0401"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-leucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUtex"]}, "metabolites": {"leu__L_p": 1.0, "leu__L_e": -1.0}, "id": "LEUtex", 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["LIPATPT"]}, "metabolites": {"ppi_c": 1.0, "lipoate_c": -1.0, "atp_c": -1.0, "lipoamp_c": 1.0}, "id": "LIPATPT", "gene_reaction_rule": "b4386"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "lipa_c": -1.0}, "id": "LIPAabcpp", "gene_reaction_rule": "b0914"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_e": 1.0, "pi_c": 1.0}, "id": "LIPAabctex", "gene_reaction_rule": "b3200 and b3201 and b3199 and b4261 and b4262"}, {"subsystem": "Cofactor and Prosthetic Group 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{"subsystem": "Transport, Outer Membrane Porin", "name": "Lipoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LIPOtex"]}, "metabolites": {"lipoate_e": -1.0, "lipoate_p": 1.0}, "id": "LIPOtex", "gene_reaction_rule": "b1377 or b2215 or b0929 or b0241"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A disaccaride synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPADSS"]}, "metabolites": {"u23ga_c": -1.0, "udp_c": 1.0, "h_c": 1.0, "lipidAds_c": 1.0, "lipidX_c": -1.0}, "id": "LPADSS", "gene_reaction_rule": "b0182"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A120pp"]}, "metabolites": {"h2o_p": -1.0, "1ddecg3p_p": -1.0, "ddca_p": 1.0, "h_p": 1.0, "glyc3p_p": 1.0}, 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"Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G180"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg180_c": -1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2G180", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "ocdcea_c": 1.0, "h_c": 1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2G181", "gene_reaction_rule": "b3825"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__L_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "LSERDHr", "gene_reaction_rule": "b1539"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Lysine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSDC"]}, "metabolites": {"15dap_c": 1.0, "co2_c": 1.0, "lys__L_c": -1.0, "h_c": -1.0}, "id": "LYSDC", "gene_reaction_rule": "b0186 or b4131"}, {"subsystem": "tRNA Charging", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "b4129 or b2890"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSabcpp"]}, "metabolites": {"h2o_c": -1.0, "lys__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lys__L_p": -1.0, "pi_c": 1.0}, "id": "LYSabcpp", "gene_reaction_rule": "b2310 and b2307 and b2306 and b2308"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt2pp"]}, "metabolites": {"lys__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": -1.0}, "id": "LYSt2pp", "gene_reaction_rule": "b2156"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "b2923"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "b3903"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Lyxose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXt2pp"]}, "metabolites": {"lyx__L_p": -1.0, "lyx__L_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "b3907"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate 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"name": "Maltohexaose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXtexi"]}, "metabolites": {"malthx_e": -1.0, "malthx_p": 1.0}, "id": "MALTHXtexi", "gene_reaction_rule": "b4036"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltopentaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltpt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "maltpt_c": 1.0, "pi_c": 1.0}, "id": "MALTPTabcpp", "gene_reaction_rule": "b4034 and b4033 and b4032 and b4035"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltopentaoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTtexi"]}, "metabolites": {"maltpt_p": 1.0, "maltpt_e": -1.0}, "id": "MALTPTtexi", 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(periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_3pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "MALt2_3pp", "gene_reaction_rule": "b4123 or b4138"}, {"subsystem": "Transport, Inner Membrane", "name": "L-malate transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt3pp"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MALt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALtex"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_e": -1.0}, "id": "MALtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Mannose-1-phosphate guanylyltransferase (GDP)", 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"mincyc_p": 1.0}, "id": "MINCYCtex", "gene_reaction_rule": "b1377 or b2215 or b0929 or b0241"}, {"subsystem": "Transport, Outer Membrane", "name": "Minocycline transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINCYCtpp"]}, "metabolites": {"mincyc_e": 1.0, "h_p": -1.0, "mincyc_p": -1.0, "h_c": 1.0}, "id": "MINCYCtpp", "gene_reaction_rule": "(b0463 and b0462 and b3035) or (b0463 and b2470 and b3035)"}, {"subsystem": "Transport, Outer Membrane", "name": "Myo-inositol phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINOHPtexi"]}, "metabolites": {"minohp_p": 1.0, "minohp_e": -1.0}, "id": "MINOHPtexi", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1App"]}, "metabolites": {"h2o_p": -1.0, "murein3px4p_p": 1.0, "alaala_p": 1.0, "murein5px4p_p": -1.0}, "id": "MLDCP1App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1Bpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "murein4p3p_p": 1.0, "murein4p4p_p": -1.0}, "id": "MLDCP1Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5p5p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2App"]}, "metabolites": {"h2o_p": -1.0, "murein5p5p_p": -1.0, "alaala_p": 1.0, "murein5p3p_p": 1.0}, "id": "MLDCP2App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2Bpp"]}, "metabolites": {"h2o_p": -1.0, "murein3p3p_p": 1.0, "murein4p3p_p": -1.0, "ala__D_p": 1.0}, "id": "MLDCP2Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP3App"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": 1.0, "murein5px3p_p": -1.0, "alaala_p": 1.0}, "id": "MLDCP3App", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein3px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP1pp"]}, "metabolites": {"murein3p3p_p": 1.0, "murein3px3p_p": -1.0, "h2o_p": -1.0}, "id": "MLDEP1pp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein5px3p_p": -1.0, "murein5p3p_p": 1.0}, "id": "MLDEP2pp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malt_c": 1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG3"]}, "metabolites": {"glc__D_c": 1.0, "maltpt_c": -1.0, "h2o_c": -1.0, "maltttr_c": 1.0}, "id": "MLTG3", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG4"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "malthx_c": -1.0}, "id": "MLTG4", "gene_reaction_rule": "b0403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "b0403"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "b2558 or b2963 or b4392 or b2813 or b2701 or b1193"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "b1193 or b2558 or b2963 or b4392 or b2813 or b2701"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "b1193 or b2963 or b2558 or b4392 or b2813 or b2701"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "b2701 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{"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMCD"]}, "metabolites": {"mmcoa__S_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ppcoa_c": 1.0}, "id": "MMCD", "gene_reaction_rule": "b2919"}, {"subsystem": "Transport, Inner Membrane", "name": "S-methylmethionine permease (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMETt2pp"]}, "metabolites": {"mmet_p": -1.0, "mmet_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "MMETt2pp", "gene_reaction_rule": "b0260"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMM"]}, "metabolites": {"mmcoa__S_c": 1.0, "succoa_c": -1.0}, "id": "MMM", "gene_reaction_rule": "b2917"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "b3915 or b0752"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "b3040"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "b4322"}, {"subsystem": "Transport, Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "b2392"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "MoaD sulfuration (nadh, assumed)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOADSUx"]}, "metabolites": {"iscssh_c": -1.0, 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"gene_reaction_rule": "b0241 or b0929 or b1377 or b2215"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin cytidine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCDS"]}, "metabolites": {"ctp_c": -1.0, "mococdp_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "moco_c": -1.0}, "id": "MOCDS", "gene_reaction_rule": "b2877"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdenum cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "mobd_c": -1.0, "moco_c": 1.0, "h_c": -2.0, "amp_c": 1.0, "mptamp_c": -1.0}, "id": "MOCOS", "gene_reaction_rule": "b0827"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOGDS"]}, "metabolites": {"moco_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "mocogdp_c": 1.0}, "id": "MOGDS", "gene_reaction_rule": "b3857 or (b3857 and b3856)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"thf_c": 1.0, "h2o_c": -1.0, "mlthf_c": -1.0, "2dhp_c": 1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "b0134"}, {"subsystem": "Citric Acid Cycle", "name": "Malate oxidase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOX"]}, "metabolites": {"o2_c": -1.0, "mal__L_c": -1.0, "oaa_c": 1.0, "h2o2_c": 1.0}, "id": "MOX", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTAT"]}, "metabolites": {"ppi_c": 1.0, "mpt_c": -1.0, "h_c": -1.0, "atp_c": -1.0, 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"NADH16pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "b2276 and b2277 and b2278 and b2279 and b2280 and b2281 and b2282 and b2283 and b2284 and b2285 and b2286 and b2287 and b2288"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": 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1.0, "h_c": 1.0, "h_p": -1.0, "psclys_p": -1.0}, "id": "PSCLYSt2pp", "gene_reaction_rule": "b3370"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Psicoselysine transporter via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSCLYStex"]}, "metabolites": {"psclys_e": -1.0, "psclys_p": 1.0}, "id": "PSCLYStex", "gene_reaction_rule": "b2215 or b1377 or b0241 or b0929"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-phosphoshikimate 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSCVT"]}, "metabolites": {"pep_c": -1.0, "pi_c": 1.0, "skm5p_c": -1.0, "3psme_c": 1.0}, "id": "PSCVT", "gene_reaction_rule": "b0908"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine decarboxylase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSD120"]}, "metabolites": {"pe120_c": 1.0, 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{"notes": {"original_bigg_ids": ["b3580"]}, "name": "lyxK", "id": "b3580"}, {"notes": {"original_bigg_ids": ["b1093"]}, "name": "fabG", "id": "b1093"}, {"notes": {"original_bigg_ids": ["b1095"]}, "name": "fabF", "id": "b1095"}, {"notes": {"original_bigg_ids": ["b2323"]}, "name": "fabB", "id": "b2323"}, {"notes": {"original_bigg_ids": ["b1397"]}, "name": "paaJ", "id": "b1397"}, {"notes": {"original_bigg_ids": ["b1245"]}, "name": "oppC", "id": "b1245"}, {"notes": {"original_bigg_ids": ["b1247"]}, "name": "oppF", "id": "b1247"}, {"notes": {"original_bigg_ids": ["b1329"]}, "name": "mppA", "id": "b1329"}, {"notes": {"original_bigg_ids": ["b1246"]}, "name": "oppD", "id": "b1246"}, {"notes": {"original_bigg_ids": ["b1244"]}, "name": "oppB", "id": "b1244"}, {"notes": {"original_bigg_ids": ["b1386"]}, "name": "tynA", "id": "b1386"}, {"notes": {"original_bigg_ids": ["b0004"]}, "name": "thrC", "id": "b0004"}, {"notes": {"original_bigg_ids": ["b1192"]}, "name": "ldcA", "id": "b1192"}, {"notes": {"original_bigg_ids": ["b1243"]}, "name": "oppA", "id": "b1243"}, {"notes": {"original_bigg_ids": ["b4266"]}, "name": "idnO", "id": "b4266"}, {"notes": {"original_bigg_ids": ["b4265"]}, "name": "idnT", "id": "b4265"}, {"notes": {"original_bigg_ids": ["b0159"]}, "name": "mtn", "id": "b0159"}, {"notes": {"original_bigg_ids": ["b2708"]}, "name": "srlQ", "id": "b2708"}, {"notes": {"original_bigg_ids": ["b3197"]}, "name": "kdsD", "id": "b3197"}, {"notes": {"original_bigg_ids": ["b1094"]}, "name": "acpP", "id": "b1094"}, {"notes": {"original_bigg_ids": ["b4481"]}, "name": "wecF", "id": "b4481"}, {"notes": {"original_bigg_ids": ["b1927"]}, "name": "amyA", "id": "b1927"}, {"notes": {"original_bigg_ids": ["b3571"]}, "name": "malS", "id": "b3571"}, {"notes": {"original_bigg_ids": ["b2901"]}, "name": "bglA", "id": "b2901"}, {"notes": {"original_bigg_ids": ["b1302"]}, "name": "puuE", "id": "b1302"}, {"notes": {"original_bigg_ids": ["b2662"]}, "name": "gabT", "id": "b2662"}, {"notes": 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{"original_bigg_ids": ["b1812"]}, "name": "pabB", "id": "b1812"}, {"notes": {"original_bigg_ids": ["b3665"]}, "name": "adeD", "id": "b3665"}, {"notes": {"original_bigg_ids": ["b3654"]}, "name": "xanP", "id": "b3654"}, {"notes": {"original_bigg_ids": ["b3714"]}, "name": "adeP", "id": "b3714"}, {"notes": {"original_bigg_ids": ["b0474"]}, "name": "adk", "id": "b0474"}, {"notes": {"original_bigg_ids": ["b0120"]}, "name": "speD", "id": "b0120"}, {"notes": {"original_bigg_ids": ["b3806"]}, "name": "cyaA", "id": "b3806"}, {"notes": {"original_bigg_ids": ["b0030"]}, "name": "rihC", "id": "b0030"}, {"notes": {"original_bigg_ids": ["b2393"]}, "name": "nupC", "id": "b2393"}, {"notes": {"original_bigg_ids": ["b2964"]}, "name": "nupG", "id": "b2964"}, {"notes": {"original_bigg_ids": ["b2406"]}, "name": "xapB", "id": "b2406"}, {"notes": {"original_bigg_ids": ["b0411"]}, "name": "tsx", "id": "b0411"}, {"notes": {"original_bigg_ids": ["b1992"]}, "name": "cobS", "id": "b1992"}, {"notes": 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{"original_bigg_ids": ["b3542"]}, "name": "dppC", "id": "b3542"}, {"notes": {"original_bigg_ids": ["b1483"]}, "name": "ddpF", "id": "b1483"}, {"notes": {"original_bigg_ids": ["b3541"]}, "name": "dppD", "id": "b3541"}, {"notes": {"original_bigg_ids": ["b3540"]}, "name": "dppF", "id": "b3540"}, {"notes": {"original_bigg_ids": ["b1487"]}, "name": "ddpA", "id": "b1487"}, {"notes": {"original_bigg_ids": ["b3544"]}, "name": "dppA", "id": "b3544"}, {"notes": {"original_bigg_ids": ["b1484"]}, "name": "ddpD", "id": "b1484"}, {"notes": {"original_bigg_ids": ["b0092"]}, "name": "ddlB", "id": "b0092"}, {"notes": {"original_bigg_ids": ["b0381"]}, "name": "ddlA", "id": "b0381"}, {"notes": {"original_bigg_ids": ["b1325"]}, "name": "ycjG", "id": "b1325"}, {"notes": {"original_bigg_ids": ["b1190"]}, "name": "dadX", "id": "b1190"}, {"notes": {"original_bigg_ids": ["b4053"]}, "name": "alr", "id": "b4053"}, {"notes": {"original_bigg_ids": ["b0870"]}, "name": "ltaE", "id": "b0870"}, {"notes": {"original_bigg_ids": ["b2551"]}, "name": "glyA", "id": "b2551"}, {"notes": {"original_bigg_ids": ["b2379"]}, "name": "alaC", "id": "b2379"}, {"notes": {"original_bigg_ids": ["b2290"]}, "name": "alaA", "id": "b2290"}, {"notes": {"original_bigg_ids": ["b2697"]}, "name": "alaS", "id": "b2697"}, {"notes": {"original_bigg_ids": ["b3455"]}, "name": "livG", "id": "b3455"}, {"notes": {"original_bigg_ids": ["b3456"]}, "name": "livM", "id": "b3456"}, {"notes": {"original_bigg_ids": ["b3460"]}, "name": "livJ", "id": "b3460"}, {"notes": {"original_bigg_ids": ["b3457"]}, "name": "livH", "id": "b3457"}, {"notes": {"original_bigg_ids": ["b3454"]}, "name": "livF", "id": "b3454"}, {"notes": {"original_bigg_ids": ["b4208"]}, "name": "cycA", "id": "b4208"}, {"notes": {"original_bigg_ids": ["b0007"]}, "name": "yaaJ", "id": "b0007"}, {"notes": {"original_bigg_ids": ["b0356"]}, "name": "frmA", "id": "b0356"}, {"notes": {"original_bigg_ids": ["b1478"]}, "name": "adhP", "id": "b1478"}, {"notes": {"original_bigg_ids": ["b1385"]}, "name": "feaB", "id": "b1385"}, {"notes": {"original_bigg_ids": ["b1300"]}, "name": "puuC", "id": "b1300"}, {"notes": {"original_bigg_ids": ["b3588"]}, "name": "aldB", "id": "b3588"}, {"notes": {"original_bigg_ids": ["b4084"]}, "name": "alsK", "id": "b4084"}, {"notes": {"original_bigg_ids": ["b4090"]}, "name": "rpiB", "id": "b4090"}, {"notes": {"original_bigg_ids": ["b0516"]}, "name": "allC", "id": "b0516"}, {"notes": {"original_bigg_ids": ["b0512"]}, "name": "allB", "id": "b0512"}, {"notes": {"original_bigg_ids": ["b0511"]}, "name": "ybbW", "id": "b0511"}, {"notes": {"original_bigg_ids": ["b4085"]}, "name": "alsE", "id": "b4085"}, {"notes": {"original_bigg_ids": ["b4088"]}, "name": "alsB", "id": "b4088"}, {"notes": {"original_bigg_ids": ["b4087"]}, "name": "alsA", "id": "b4087"}, {"notes": {"original_bigg_ids": ["b4086"]}, "name": "alsC", "id": "b4086"}, {"notes": {"original_bigg_ids": ["b1677"]}, "name": "lpp", "id": "b1677"}, {"notes": 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{"name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hpalmACP_c"]}, "charge": -1, "formula": "C27H51N2O9PRS", "compartment": "c", "id": "3hpalmACP_c"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_c"]}, "charge": -1, "formula": "C3H5O3", "compartment": "c", "id": "3hpp_c"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_c"]}, "charge": -1, "formula": "C9H9O3", "compartment": "c", "id": "3hpppn_c"}, {"name": "(S)-3-Hydroxytetradecanoyl-CoA", "notes": {"original_bigg_ids": ["3htdcoa_c"]}, "charge": -4, "formula": "C35H58N7O18P3S", "compartment": "c", "id": "3htdcoa_c"}, {"name": "C'-(3-Indolyl)-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["3ig3p_c"]}, "charge": -2, "formula": "C11H12NO6P", "compartment": "c", "id": "3ig3p_c"}, {"name": "3-Methyl-2-oxobutanoate", "notes": {"original_bigg_ids": ["3mob_c"]}, "charge": -1, "formula": "C5H7O3", "compartment": "c", "id": "3mob_c"}, {"name": "(S)-3-Methyl-2-oxopentanoate", "notes": {"original_bigg_ids": ["3mop_c"]}, "charge": -1, "formula": "C6H9O3", "compartment": "c", "id": "3mop_c"}, {"name": "3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocddec5eACP_c"]}, "charge": -1, "formula": "C23H39N2O9PRS", "compartment": "c", "id": "3ocddec5eACP_c"}, {"name": "3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocmrs7eACP_c"]}, "charge": -1, "formula": "C25H43N2O9PRS", "compartment": "c", "id": "3ocmrs7eACP_c"}, {"name": "3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocpalm9eACP_c"]}, "charge": -1, "formula": "C27H47N2O9PRS", "compartment": "c", "id": "3ocpalm9eACP_c"}, {"name": "3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocvac11eACP_c"]}, "charge": -1, "formula": "C29H51N2O9PRS", "compartment": "c", "id": "3ocvac11eACP_c"}, {"name": "3-Oxodecanoyl-CoA", "notes": 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"C22H33N4O13", "compartment": "c", "id": "arbtn_c"}, {"name": "Aerobactin", "notes": {"original_bigg_ids": ["arbtn_DASH_fe3_c"]}, "charge": 0, "formula": "C22H33FeN4O13", "compartment": "c", "id": "arbtn_fe3_c"}, {"name": "L-Arginine", "notes": {"original_bigg_ids": ["arg_DASH_L_c"]}, "charge": 1, "formula": "C6H15N4O2", "compartment": "c", "id": "arg__L_c"}, {"name": "N(omega)-(L-Arginino)succinate", "notes": {"original_bigg_ids": ["argsuc_c"]}, "charge": -1, "formula": "C10H17N4O6", "compartment": "c", "id": "argsuc_c"}, {"name": "L-Arginyl-tRNA(Arg)", "notes": {"original_bigg_ids": ["argtrna_c"]}, "charge": 2, "formula": "C6H14N4OR", "compartment": "c", "id": "argtrna_c"}, {"name": "L-ascorbate-6-phosphate", "notes": {"original_bigg_ids": ["ascb6p_c"]}, "charge": -2, "formula": "C6H7O9P", "compartment": "c", "id": "ascb6p_c"}, {"name": "L-Asparagine", "notes": {"original_bigg_ids": ["asn_DASH_L_c"]}, "charge": 0, "formula": "C4H8N2O3", "compartment": "c", "id": "asn__L_c"}, {"name": 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"C19H22N8O15P2S2Mo", "compartment": "c", "id": "mococdp_c"}, {"name": "Molybdopterin guanine dinucleotide", "notes": {"original_bigg_ids": ["mocogdp_c"]}, "charge": -2, "formula": "C20H22N10O15P2S2Mo", "compartment": "c", "id": "mocogdp_c"}, {"name": "Molybdopterin", "notes": {"original_bigg_ids": ["mpt_c"]}, "charge": -2, "formula": "C10H10N5O6PS2Cu", "compartment": "c", "id": "mpt_c"}, {"name": "Adenylated molybdopterin", "notes": {"original_bigg_ids": ["mptamp_c"]}, "charge": -2, "formula": "C20H22N10O12P2S2Cu", "compartment": "c", "id": "mptamp_c"}, {"name": "Menaquinol 8", "notes": {"original_bigg_ids": ["mql8_c"]}, "charge": 0, "formula": "C51H74O2", "compartment": "c", "id": "mql8_c"}, {"name": "Menaquinone 8", "notes": {"original_bigg_ids": ["mqn8_c"]}, "charge": 0, "formula": "C51H72O2", "compartment": "c", "id": "mqn8_c"}, {"name": "Malonate semialdehyde", "notes": {"original_bigg_ids": ["msa_c"]}, "charge": -1, "formula": "C3H3O3", "compartment": "c", "id": "msa_c"}, 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"C15H22N2O17P2", "compartment": "c", "id": "udpg_c"}, {"name": "UDPgalactose", "notes": {"original_bigg_ids": ["udpgal_c"]}, "charge": -2, "formula": "C15H22N2O17P2", "compartment": "c", "id": "udpgal_c"}, {"name": "UDP-D-galacto-1,4-furanose", "notes": {"original_bigg_ids": ["udpgalfur_c"]}, "charge": -2, "formula": "C15H22N2O17P2", "compartment": "c", "id": "udpgalfur_c"}, {"name": "UDP-D-glucuronate", "notes": {"original_bigg_ids": ["udpglcur_c"]}, "charge": -3, "formula": "C15H19N2O18P2", "compartment": "c", "id": "udpglcur_c"}, {"name": "UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate", "notes": {"original_bigg_ids": ["ugmd_c"]}, "charge": -4, "formula": "C35H51N7O26P2", "compartment": "c", "id": "ugmd_c"}, {"name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["ugmda_c"]}, "charge": -4, "formula": "C41H61N9O28P2", "compartment": "c", "id": "ugmda_c"}, {"name": 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"Uroporphyrinogen III", "notes": {"original_bigg_ids": ["uppg3_c"]}, "charge": -8, "formula": "C40H36N4O16", "compartment": "c", "id": "uppg3_c"}, {"name": "Uracil", "notes": {"original_bigg_ids": ["ura_c"]}, "charge": 0, "formula": "C4H4N2O2", "compartment": "c", "id": "ura_c"}, {"name": "Ureidoacrylate peracid", "notes": {"original_bigg_ids": ["uracp_c"]}, "charge": 0, "formula": "C4H6N2O4", "compartment": "c", "id": "uracp_c"}, {"name": "Urate", "notes": {"original_bigg_ids": ["urate_c"]}, "charge": 0, "formula": "C5H4N4O3", "compartment": "c", "id": "urate_c"}, {"name": "(-)-Ureidoglycolate", "notes": {"original_bigg_ids": ["urdglyc_c"]}, "charge": -1, "formula": "C3H5N2O4", "compartment": "c", "id": "urdglyc_c"}, {"name": "Urea", "notes": {"original_bigg_ids": ["urea_c"]}, "charge": 0, "formula": "CH4N2O", "compartment": "c", "id": "urea_c"}, {"name": "Uridine", "notes": {"original_bigg_ids": ["uri_c"]}, "charge": 0, "formula": "C9H12N2O6", "compartment": "c", "id": "uri_c"}, 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"compartment": "c", "id": "xmp_c"}, {"name": "XTP", "notes": {"original_bigg_ids": ["xtp_c"]}, "charge": -4, "formula": "C10H11N4O15P3", "compartment": "c", "id": "xtp_c"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_c"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "c", "id": "xtsn_c"}, {"name": "D-Xylulose 5-phosphate", "notes": {"original_bigg_ids": ["xu5p_DASH_D_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "xu5p__D_c"}, {"name": "L-Xylulose 5-phosphate", "notes": {"original_bigg_ids": ["xu5p_DASH_L_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "xu5p__L_c"}, {"name": "D-Xylose", "notes": {"original_bigg_ids": ["xyl_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "xyl__D_c"}, {"name": "D-Xylulose", "notes": {"original_bigg_ids": ["xylu_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "xylu__D_c"}, {"name": "L-Xylulose", "notes": {"original_bigg_ids": ["xylu_DASH_L_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "xylu__L_c"}, {"name": "Zinc", "notes": {"original_bigg_ids": ["zn2_c"]}, "charge": 2, "formula": "Zn", "compartment": "c", "id": "zn2_c"}, {"name": "(R)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_R_e"]}, "charge": 0, "formula": "C3H8O2", "compartment": "e", "id": "12ppd__R_e"}, {"name": "(S)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_S_e"]}, "charge": 0, "formula": "C3H8O2", "compartment": "e", "id": "12ppd__S_e"}, {"name": "1,4-alpha-D-glucan", "notes": {"original_bigg_ids": ["14glucan_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "14glucan_e"}, {"name": "1,5-Diaminopentane", "notes": {"original_bigg_ids": ["15dap_e"]}, "charge": 2, "formula": "C5H16N2", "compartment": "e", "id": "15dap_e"}, {"name": "2',3'-Cyclic AMP", "notes": {"original_bigg_ids": ["23camp_e"]}, "charge": -1, "formula": "C10H11N5O6P", "compartment": "e", "id": "23camp_e"}, {"name": "2',3'-Cyclic CMP", "notes": {"original_bigg_ids": ["23ccmp_e"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "e", "id": "23ccmp_e"}, {"name": "2',3'-Cyclic GMP", "notes": {"original_bigg_ids": ["23cgmp_e"]}, "charge": -1, "formula": "C10H11N5O7P", "compartment": "e", "id": "23cgmp_e"}, {"name": "2',3'-Cyclic UMP", "notes": {"original_bigg_ids": ["23cump_e"]}, "charge": -1, "formula": "C9H10N2O8P", "compartment": "e", "id": "23cump_e"}, {"name": "2,3-diaminopropionate", "notes": {"original_bigg_ids": ["23dappa_e"]}, "charge": 1, "formula": "C3H9N2O2", "compartment": "e", "id": "23dappa_e"}, {"name": "Meso-2,6-Diaminoheptanedioate", "notes": {"original_bigg_ids": ["26dap_DASH_M_e"]}, "charge": 0, "formula": "C7H14N2O4", "compartment": "e", "id": "26dap__M_e"}, {"name": "2-Dehydro-3-deoxy-D-gluconate", "notes": {"original_bigg_ids": ["2ddglcn_e"]}, "charge": -1, "formula": "C6H9O6", "compartment": "e", "id": "2ddglcn_e"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", 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"3hpppn_e"}, {"name": "3'-UMP", "notes": {"original_bigg_ids": ["3ump_e"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "e", "id": "3ump_e"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_e"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "e", "id": "4abut_e"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_e"]}, "charge": 0, "formula": "C8H8O2", "compartment": "e", "id": "4hoxpacd_e"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_e"]}, "charge": -1, "formula": "C6H9O7", "compartment": "e", "id": "5dglcn_e"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_e"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "e", "id": "5mtr_e"}, {"name": "L-alanine-D-glutamate", "notes": {"original_bigg_ids": ["LalaDglu_e"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "e", "id": "LalaDglu_e"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": 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["acgal_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acgal_e"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgal1p_e"}, {"name": "N-Acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["acgam_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acgam_e"}, {"name": "N-Acetyl-D-glucosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgam1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgam1p_e"}, {"name": "N-Acetyl-D-mannosamine", "notes": {"original_bigg_ids": ["acmana_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acmana_e"}, {"name": "N-Acetylmuramate", "notes": {"original_bigg_ids": ["acmum_e"]}, "charge": -1, "formula": "C11H18NO8", "compartment": "e", "id": "acmum_e"}, {"name": "N-Acetylneuraminate", "notes": {"original_bigg_ids": ["acnam_e"]}, "charge": -1, "formula": "C11H18NO9", "compartment": "e", "id": "acnam_e"}, {"name": "4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["acolipa_e"]}, "charge": -9, "formula": "C181H314N3O103P4", "compartment": "e", "id": "acolipa_e"}, {"name": "O-Acetyl-L-serine", "notes": {"original_bigg_ids": ["acser_e"]}, "charge": 0, "formula": "C5H9NO4", "compartment": "e", "id": "acser_e"}, {"name": "Adenine", "notes": {"original_bigg_ids": ["ade_e"]}, "charge": 0, "formula": "C5H5N5", "compartment": "e", "id": "ade_e"}, {"name": "Adenosine", "notes": {"original_bigg_ids": ["adn_e"]}, "charge": 0, "formula": "C10H13N5O4", "compartment": "e", "id": "adn_e"}, {"name": "Adenosylcobalamin", "notes": {"original_bigg_ids": ["adocbl_e"]}, "charge": 0, "formula": "C72H100CoN18O17P", "compartment": "e", "id": "adocbl_e"}, {"name": "Silver", "notes": {"original_bigg_ids": ["ag_e"]}, "charge": 1, "formula": "Ag", "compartment": "e", "id": "ag_e"}, {"name": "Agmatine", "notes": 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"C22H33FeN4O13", "compartment": "e", "id": "arbtn_fe3_e"}, {"name": "L-Arginine", "notes": {"original_bigg_ids": ["arg_DASH_L_e"]}, "charge": 1, "formula": "C6H15N4O2", "compartment": "e", "id": "arg__L_e"}, {"name": "L-Ascorbate", "notes": {"original_bigg_ids": ["ascb_DASH_L_e"]}, "charge": 0, "formula": "C6H8O6", "compartment": "e", "id": "ascb__L_e"}, {"name": "L-Asparagine", "notes": {"original_bigg_ids": ["asn_DASH_L_e"]}, "charge": 0, "formula": "C4H8N2O3", "compartment": "e", "id": "asn__L_e"}, {"name": "Arsenite", "notes": {"original_bigg_ids": ["aso3_e"]}, "charge": -3, "formula": "AsO3", "compartment": "e", "id": "aso3_e"}, {"name": "L-Aspartate", "notes": {"original_bigg_ids": ["asp_DASH_L_e"]}, "charge": -1, "formula": "C4H6NO4", "compartment": "e", "id": "asp__L_e"}, {"name": "Biotin", "notes": {"original_bigg_ids": ["btn_e"]}, "charge": -1, "formula": "C10H15N2O3S", "compartment": "e", "id": "btn_e"}, {"name": "Butyrate (n-C4:0)", "notes": {"original_bigg_ids": ["but_e"]}, "charge": -1, "formula": "C4H7O2", "compartment": "e", "id": "but_e"}, {"name": "Butanesulfonate", "notes": {"original_bigg_ids": ["butso3_e"]}, "charge": -1, "formula": "C4H9O3S", "compartment": "e", "id": "butso3_e"}, {"name": "Calcium", "notes": {"original_bigg_ids": ["ca2_e"]}, "charge": 2, "formula": "Ca", "compartment": "e", "id": "ca2_e"}, {"name": "Cobinamide", "notes": {"original_bigg_ids": ["cbi_e"]}, "charge": 0, "formula": "C48H72CoN11O8", "compartment": "e", "id": "cbi_e"}, {"name": "Cob(I)alamin", "notes": {"original_bigg_ids": ["cbl1_e"]}, "charge": -1, "formula": "C62H88CoN13O14P", "compartment": "e", "id": "cbl1_e"}, {"name": "Cadmium", "notes": {"original_bigg_ids": ["cd2_e"]}, "charge": 2, "formula": "Cd", "compartment": "e", "id": "cd2_e"}, {"name": "Cys-Gly", "notes": {"original_bigg_ids": ["cgly_e"]}, "charge": 0, "formula": "C5H10N2O3S", "compartment": "e", "id": "cgly_e"}, {"name": "Choline", "notes": {"original_bigg_ids": ["chol_e"]}, "charge": 1, 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"id": "cobalt2_e"}, {"name": "Core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["colipa_e"]}, "charge": -11, "formula": "C176H303N2O100P4", "compartment": "e", "id": "colipa_e"}, {"name": "Core oligosaccharide lipid A diphosphate", "notes": {"original_bigg_ids": ["colipap_e"]}, "charge": -12, "formula": "C176H303N2O103P5", "compartment": "e", "id": "colipap_e"}, {"name": "Coprogen", "notes": {"original_bigg_ids": ["cpgn_e"]}, "charge": -1, "formula": "C35H52N6O13Fe", "compartment": "e", "id": "cpgn_e"}, {"name": "Coprogen unloaded (no Fe(III))", "notes": {"original_bigg_ids": ["cpgn_DASH_un_e"]}, "charge": -4, "formula": "C35H52N6O13", "compartment": "e", "id": "cpgn_un_e"}, {"name": "L-Carnitine", "notes": {"original_bigg_ids": ["crn_e"]}, "charge": 0, "formula": "C7H15NO3", "compartment": "e", "id": "crn_e"}, {"name": "D-Carnitine", "notes": {"original_bigg_ids": ["crn_DASH_D_e"]}, "charge": 0, "formula": "C7H15NO3", "compartment": "e", "id": "crn__D_e"}, {"name": 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["cytd_e"]}, "charge": 0, "formula": "C9H13N3O5", "compartment": "e", "id": "cytd_e"}, {"name": "Deoxyadenosine", "notes": {"original_bigg_ids": ["dad_DASH_2_e"]}, "charge": 0, "formula": "C10H13N5O3", "compartment": "e", "id": "dad_2_e"}, {"name": "DAMP", "notes": {"original_bigg_ids": ["damp_e"]}, "charge": -2, "formula": "C10H12N5O6P", "compartment": "e", "id": "damp_e"}, {"name": "Decanoate (n-C10:0)", "notes": {"original_bigg_ids": ["dca_e"]}, "charge": -1, "formula": "C10H19O2", "compartment": "e", "id": "dca_e"}, {"name": "DCMP", "notes": {"original_bigg_ids": ["dcmp_e"]}, "charge": -2, "formula": "C9H12N3O7P", "compartment": "e", "id": "dcmp_e"}, {"name": "Deoxycytidine", "notes": {"original_bigg_ids": ["dcyt_e"]}, "charge": 0, "formula": "C9H13N3O4", "compartment": "e", "id": "dcyt_e"}, {"name": "Dodecanoate (n-C12:0)", "notes": {"original_bigg_ids": ["ddca_e"]}, "charge": -1, "formula": "C12H23O2", "compartment": "e", "id": "ddca_e"}, {"name": "DGMP", "notes": 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{"name": "Glycerol", "notes": {"original_bigg_ids": ["glyc_e"]}, "charge": 0, "formula": "C3H8O3", "compartment": "e", "id": "glyc_e"}, {"name": "(R)-Glycerate", "notes": {"original_bigg_ids": ["glyc_DASH_R_e"]}, "charge": -1, "formula": "C3H5O4", "compartment": "e", "id": "glyc__R_e"}, {"name": "Glycerol 2-phosphate", "notes": {"original_bigg_ids": ["glyc2p_e"]}, "charge": -2, "formula": "C3H7O6P", "compartment": "e", "id": "glyc2p_e"}, {"name": "Glycerol 3-phosphate", "notes": {"original_bigg_ids": ["glyc3p_e"]}, "charge": -2, "formula": "C3H7O6P", "compartment": "e", "id": "glyc3p_e"}, {"name": "Glycolate", "notes": {"original_bigg_ids": ["glyclt_e"]}, "charge": -1, "formula": "C2H3O3", "compartment": "e", "id": "glyclt_e"}, {"name": "GMP", "notes": {"original_bigg_ids": ["gmp_e"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "e", "id": "gmp_e"}, {"name": "Guanosine", "notes": {"original_bigg_ids": ["gsn_e"]}, "charge": 0, "formula": "C10H13N5O5", "compartment": "e", "id": "gsn_e"}, {"name": "Oxidized glutathione", "notes": {"original_bigg_ids": ["gthox_e"]}, "charge": -2, "formula": "C20H30N6O12S2", "compartment": "e", "id": "gthox_e"}, {"name": "Reduced glutathione", "notes": {"original_bigg_ids": ["gthrd_e"]}, "charge": -1, "formula": "C10H16N3O6S", "compartment": "e", "id": "gthrd_e"}, {"name": "GTP", "notes": {"original_bigg_ids": ["gtp_e"]}, "charge": -4, "formula": "C10H12N5O14P3", "compartment": "e", "id": "gtp_e"}, {"name": "Guanine", "notes": {"original_bigg_ids": ["gua_e"]}, "charge": 0, "formula": "C5H5N5O", "compartment": "e", "id": "gua_e"}, {"name": "H+", "notes": {"original_bigg_ids": ["h_e"]}, "charge": 1, "formula": "H", "compartment": "e", "id": "h_e"}, {"name": "H2", "notes": {"original_bigg_ids": ["h2_e"]}, "charge": 0, "formula": "H2", "compartment": "e", "id": "h2_e"}, {"name": "H2O", "notes": {"original_bigg_ids": ["h2o_e"]}, "charge": 0, "formula": "H2O", "compartment": "e", "id": "h2o_e"}, {"name": "Hydrogen peroxide", "notes": {"original_bigg_ids": ["h2o2_e"]}, "charge": 0, "formula": "H2O2", "compartment": "e", "id": "h2o2_e"}, {"name": "Hydrogen sulfide", "notes": {"original_bigg_ids": ["h2s_e"]}, "charge": 0, "formula": "H2S", "compartment": "e", "id": "h2s_e"}, {"name": "Hepta-acylated core oligosaccharide lipid A (E. coli)", "notes": {"original_bigg_ids": ["hacolipa_e"]}, "charge": -11, "formula": "C192H333N2O101P4", "compartment": "e", "id": "hacolipa_e"}, {"name": "Hepta-acylated KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["halipa_e"]}, "charge": -6, "formula": "C126H226N2O40P2", "compartment": "e", "id": "halipa_e"}, {"name": "Hexadecanoate (n-C16:0)", "notes": {"original_bigg_ids": ["hdca_e"]}, "charge": -1, "formula": "C16H31O2", "compartment": "e", "id": "hdca_e"}, {"name": "Hexadecenoate (n-C16:1)", "notes": {"original_bigg_ids": ["hdcea_e"]}, "charge": -1, "formula": "C16H29O2", "compartment": "e", "id": "hdcea_e"}, {"name": "Hg2+", "notes": {"original_bigg_ids": ["hg2_e"]}, "charge": 2, "formula": "Hg", "compartment": "e", "id": "hg2_e"}, {"name": "L-Histidine", "notes": {"original_bigg_ids": ["his_DASH_L_e"]}, "charge": 0, "formula": "C6H9N3O2", "compartment": "e", "id": "his__L_e"}, {"name": "L-Homoserine", "notes": {"original_bigg_ids": ["hom_DASH_L_e"]}, "charge": 0, "formula": "C4H9NO3", "compartment": "e", "id": "hom__L_e"}, {"name": "Hexanoate (n-C6:0)", "notes": {"original_bigg_ids": ["hxa_e"]}, "charge": -1, "formula": "C6H11O2", "compartment": "e", "id": "hxa_e"}, {"name": "Hypoxanthine", "notes": {"original_bigg_ids": ["hxan_e"]}, "charge": 0, "formula": "C5H4N4O", "compartment": "e", "id": "hxan_e"}, {"name": "L-Idonate", "notes": {"original_bigg_ids": ["idon_DASH_L_e"]}, "charge": -1, "formula": "C6H11O7", "compartment": "e", "id": "idon__L_e"}, {"name": "L-Isoleucine", "notes": {"original_bigg_ids": ["ile_DASH_L_e"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "e", "id": "ile__L_e"}, {"name": "IMP", "notes": {"original_bigg_ids": ["imp_e"]}, "charge": -2, "formula": "C10H11N4O8P", "compartment": "e", "id": "imp_e"}, {"name": "Indole", "notes": {"original_bigg_ids": ["indole_e"]}, "charge": 0, "formula": "C8H7N", "compartment": "e", "id": "indole_e"}, {"name": "Myo-Inositol", "notes": {"original_bigg_ids": ["inost_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "inost_e"}, {"name": "Inosine", "notes": {"original_bigg_ids": ["ins_e"]}, "charge": 0, "formula": "C10H12N4O5", "compartment": "e", "id": "ins_e"}, {"name": "Isethionic acid", "notes": {"original_bigg_ids": ["isetac_e"]}, "charge": -1, "formula": "C2H5O4S", "compartment": "e", "id": "isetac_e"}, {"name": "Potassium", "notes": {"original_bigg_ids": ["k_e"]}, "charge": 1, "formula": "K", "compartment": "e", "id": "k_e"}, {"name": "KDO(2)-lipid IV(A)", "notes": {"original_bigg_ids": ["kdo2lipid4_e"]}, "charge": -6, "formula": "C84H148N2O37P2", "compartment": "e", "id": "kdo2lipid4_e"}, {"name": "D-Lactate", "notes": {"original_bigg_ids": ["lac_DASH_D_e"]}, "charge": -1, "formula": "C3H5O3", "compartment": "e", "id": "lac__D_e"}, {"name": "L-Lactate", "notes": {"original_bigg_ids": ["lac_DASH_L_e"]}, "charge": -1, "formula": "C3H5O3", "compartment": "e", "id": "lac__L_e"}, {"name": "Lactose", "notes": {"original_bigg_ids": ["lcts_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "lcts_e"}, {"name": "L-Leucine", "notes": {"original_bigg_ids": ["leu_DASH_L_e"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "e", "id": "leu__L_e"}, {"name": "KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["lipa_e"]}, "charge": -6, "formula": "C110H196N2O39P2", "compartment": "e", "id": "lipa_e"}, {"name": "Cold adapted KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["lipa_cold_e"]}, "charge": -6, "formula": "C114H202N2O39P2", "compartment": "e", "id": "lipa_cold_e"}, {"name": "Lipoate", "notes": {"original_bigg_ids": ["lipoate_e"]}, "charge": 0, "formula": "C8H14O2S2", "compartment": "e", "id": "lipoate_e"}, {"name": "L-Lysine", "notes": {"original_bigg_ids": ["lys_DASH_L_e"]}, "charge": 1, "formula": "C6H15N2O2", "compartment": "e", "id": "lys__L_e"}, {"name": "L-Lyxose", "notes": {"original_bigg_ids": ["lyx_DASH_L_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "lyx__L_e"}, {"name": "D-Malate", "notes": {"original_bigg_ids": ["mal_DASH_D_e"]}, "charge": -2, "formula": "C4H4O5", "compartment": "e", "id": "mal__D_e"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_DASH_L_e"]}, "charge": -2, "formula": "C4H4O5", "compartment": "e", "id": "mal__L_e"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "malt_e"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "malthx_e"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_e"]}, "charge": 0, "formula": "C30H52O26", "compartment": "e", "id": "maltpt_e"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "malttr_e"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_e"]}, "charge": 0, "formula": "C24H42O21", "compartment": "e", "id": "maltttr_e"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "man_e"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "man6p_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": -1, "formula": "C9H15O9", "compartment": "e", "id": "manglyc_e"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "melib_e"}, {"name": "Methanol", "notes": {"original_bigg_ids": ["meoh_e"]}, "charge": 0, "formula": "CH4O1", "compartment": "e", "id": "meoh_e"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_DASH_D_e"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "e", "id": "met__D_e"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "e", "id": "met__L_e"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_R__L_e"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_S_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_S__L_e"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_e"]}, "charge": 2, "formula": "Mg", "compartment": "e", "id": "mg2_e"}, {"name": "Minocycline", "notes": {"original_bigg_ids": ["mincyc_e"]}, "charge": 0, "formula": "C23H27N3O7", "compartment": "e", "id": "mincyc_e"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_e"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "e", "id": "minohp_e"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_e"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "e", "id": "mmet_e"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_e"]}, "charge": 2, "formula": "Mn", "compartment": "e", "id": "mn2_e"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "mnl_e"}, {"name": "Molybdate", "notes": {"original_bigg_ids": ["mobd_e"]}, "charge": -2, "formula": "MoO4", "compartment": "e", "id": "mobd_e"}, {"name": "Methanesulfonate", "notes": {"original_bigg_ids": ["mso3_e"]}, "charge": -1, "formula": "CH3O3S", "compartment": "e", "id": "mso3_e"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_e"]}, "charge": 0, "formula": "N2O", "compartment": "e", "id": "n2o_e"}, {"name": "Sodium", "notes": {"original_bigg_ids": ["na1_e"]}, "charge": 1, "formula": "Na", "compartment": "e", "id": "na1_e"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_e"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "e", "id": "nac_e"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_e"]}, "charge": 1, "formula": "H4N", "compartment": "e", "id": "nh4_e"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_e"]}, "charge": 2, "formula": "Ni", "compartment": "e", "id": "ni2_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "e", "id": "nmn_e"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_e"]}, "charge": 0, "formula": "NO", "compartment": "e", "id": "no_e"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_e"]}, "charge": -1, "formula": "NO2", "compartment": "e", "id": "no2_e"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_e"]}, "charge": -1, 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"id": "sbt__D_e"}, {"name": "Selenate", "notes": {"original_bigg_ids": ["sel_e"]}, "charge": -2, "formula": "O4Se", "compartment": "e", "id": "sel_e"}, {"name": "D-Serine", "notes": {"original_bigg_ids": ["ser_DASH_D_e"]}, "charge": 0, "formula": "C3H7NO3", "compartment": "e", "id": "ser__D_e"}, {"name": "L-Serine", "notes": {"original_bigg_ids": ["ser_DASH_L_e"]}, "charge": 0, "formula": "C3H7NO3", "compartment": "e", "id": "ser__L_e"}, {"name": "Shikimate", "notes": {"original_bigg_ids": ["skm_e"]}, "charge": -1, "formula": "C7H9O5", "compartment": "e", "id": "skm_e"}, {"name": "Selenite", "notes": {"original_bigg_ids": ["slnt_e"]}, "charge": -2, "formula": "O3Se", "compartment": "e", "id": "slnt_e"}, {"name": "Sulfur dioxide", "notes": {"original_bigg_ids": ["so2_e"]}, "charge": 0, "formula": "O2S", "compartment": "e", "id": "so2_e"}, {"name": "Sulfite", "notes": {"original_bigg_ids": ["so3_e"]}, "charge": -2, "formula": "O3S", "compartment": "e", "id": "so3_e"}, {"name": "Sulfate", "notes": {"original_bigg_ids": ["so4_e"]}, "charge": -2, "formula": "O4S", "compartment": "e", "id": "so4_e"}, {"name": "Spermidine", "notes": {"original_bigg_ids": ["spmd_e"]}, "charge": 3, "formula": "C7H22N3", "compartment": "e", "id": "spmd_e"}, {"name": "Succinate", "notes": {"original_bigg_ids": ["succ_e"]}, "charge": -2, "formula": "C4H4O4", "compartment": "e", "id": "succ_e"}, {"name": "Sucrose", "notes": {"original_bigg_ids": ["sucr_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "sucr_e"}, {"name": "Sulfoacetate", "notes": {"original_bigg_ids": ["sulfac_e"]}, "charge": -2, "formula": "C2H2O5S", "compartment": "e", "id": "sulfac_e"}, {"name": "D-tartrate", "notes": {"original_bigg_ids": ["tartr_DASH_D_e"]}, "charge": -2, "formula": "C4H4O6", "compartment": "e", "id": "tartr__D_e"}, {"name": "L-tartrate", "notes": {"original_bigg_ids": ["tartr_DASH_L_e"]}, "charge": -2, "formula": "C4H4O6", "compartment": "e", "id": "tartr__L_e"}, {"name": "Taurine", 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"Trimethylamine", "notes": {"original_bigg_ids": ["tma_e"]}, "charge": 1, "formula": "C3H10N", "compartment": "e", "id": "tma_e"}, {"name": "Trimethylamine N-oxide", "notes": {"original_bigg_ids": ["tmao_e"]}, "charge": 0, "formula": "C3H9NO", "compartment": "e", "id": "tmao_e"}, {"name": "Trehalose", "notes": {"original_bigg_ids": ["tre_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "tre_e"}, {"name": "L-Tryptophan", "notes": {"original_bigg_ids": ["trp_DASH_L_e"]}, "charge": 0, "formula": "C11H12N2O2", "compartment": "e", "id": "trp__L_e"}, {"name": "Thiosulfate", "notes": {"original_bigg_ids": ["tsul_e"]}, "charge": -2, "formula": "O3S2", "compartment": "e", "id": "tsul_e"}, {"name": "Tetradecanoate (n-C14:0)", "notes": {"original_bigg_ids": ["ttdca_e"]}, "charge": -1, "formula": "C14H27O2", "compartment": "e", "id": "ttdca_e"}, {"name": "Tetradecenoate (n-C14:1)", "notes": {"original_bigg_ids": ["ttdcea_e"]}, "charge": -1, "formula": "C14H25O2", "compartment": "e", "id": "ttdcea_e"}, {"name": "Tetracycline", "notes": {"original_bigg_ids": ["ttrcyc_e"]}, "charge": 0, "formula": "C22H24N2O8", "compartment": "e", "id": "ttrcyc_e"}, {"name": "Tungstate", "notes": {"original_bigg_ids": ["tungs_e"]}, "charge": -2, "formula": "O4W1", "compartment": "e", "id": "tungs_e"}, {"name": "Tyramine", "notes": {"original_bigg_ids": ["tym_e"]}, "charge": 1, "formula": "C8H12NO", "compartment": "e", "id": "tym_e"}, {"name": "L-Tyrosine", "notes": {"original_bigg_ids": ["tyr_DASH_L_e"]}, "charge": 0, "formula": "C9H11NO3", "compartment": "e", "id": "tyr__L_e"}, {"name": "Phosphotyrosine", "notes": {"original_bigg_ids": ["tyrp_e"]}, "charge": -2, "formula": "C9H10NO6P", "compartment": "e", "id": "tyrp_e"}, {"name": "UDP-N-acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["uacgam_e"]}, "charge": -2, "formula": "C17H25N3O17P2", "compartment": "e", "id": "uacgam_e"}, {"name": "UDP-N-acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["udpacgal_e"]}, 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"K", "compartment": "p", "id": "k_p"}, {"name": "KDO(2)-lipid IV(A)", "notes": {"original_bigg_ids": ["kdo2lipid4_p"]}, "charge": -6, "formula": "C84H148N2O37P2", "compartment": "p", "id": "kdo2lipid4_p"}, {"name": "D-Lactate", "notes": {"original_bigg_ids": ["lac_DASH_D_p"]}, "charge": -1, "formula": "C3H5O3", "compartment": "p", "id": "lac__D_p"}, {"name": "L-Lactate", "notes": {"original_bigg_ids": ["lac_DASH_L_p"]}, "charge": -1, "formula": "C3H5O3", "compartment": "p", "id": "lac__L_p"}, {"name": "Lactose", "notes": {"original_bigg_ids": ["lcts_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "lcts_p"}, {"name": "L-Leucine", "notes": {"original_bigg_ids": ["leu_DASH_L_p"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "p", "id": "leu__L_p"}, {"name": "KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["lipa_p"]}, "charge": -6, "formula": "C110H196N2O39P2", "compartment": "p", "id": "lipa_p"}, {"name": "Cold adapted KDO(2)-lipid (A)", "notes": 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"Maltose", "notes": {"original_bigg_ids": ["malt_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "malt_p"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_p"]}, "charge": 0, "formula": "C36H62O31", "compartment": "p", "id": "malthx_p"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_p"]}, "charge": 0, "formula": "C30H52O26", "compartment": "p", "id": "maltpt_p"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "malttr_p"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_p"]}, "charge": 0, "formula": "C24H42O21", "compartment": "p", "id": "maltttr_p"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "man_p"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_p"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "p", "id": "man6p_p"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_p"]}, "charge": -1, "formula": "C9H15O9", "compartment": "p", "id": "manglyc_p"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "melib_p"}, {"name": "Methanol", "notes": {"original_bigg_ids": ["meoh_p"]}, "charge": 0, "formula": "CH4O1", "compartment": "p", "id": "meoh_p"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_DASH_D_p"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "p", "id": "met__D_p"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_p"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "p", "id": "met__L_p"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_p"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "p", "id": "metsox_R__L_p"}, {"name": "L-Methionine Sulfoxide", "notes": 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"Molybdate", "notes": {"original_bigg_ids": ["mobd_p"]}, "charge": -2, "formula": "MoO4", "compartment": "p", "id": "mobd_p"}, {"name": "Methanesulfonate", "notes": {"original_bigg_ids": ["mso3_p"]}, "charge": -1, "formula": "CH3O3S", "compartment": "p", "id": "mso3_p"}, {"name": "Two linked disacharide tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein3p3p_p"]}, "charge": -4, "formula": "C68H104N12O38", "compartment": "p", "id": "murein3p3p_p"}, {"name": "Two disacharide linked murein units, tripeptide crosslinked tripeptide (A2pm->A2pm) (middle of chain)", "notes": {"original_bigg_ids": ["murein3px3p_p"]}, "charge": -4, "formula": "C68H102N12O37", "compartment": "p", "id": "murein3px3p_p"}, {"name": "Two disacharide linked murein units, tripeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein3px4p_p"]}, "charge": -4, "formula": "C71H107N13O38", "compartment": "p", "id": 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"compartment": "p", "id": "murein4px4p4p_p"}, {"name": "Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4px4p_p"]}, "charge": -6, "formula": "C111H167N21O58", "compartment": "p", "id": "murein4px4px4p_p"}, {"name": "Two linked disacharide pentapeptide and tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p3p_p"]}, "charge": -4, "formula": "C74H114N14O40", "compartment": "p", "id": "murein5p3p_p"}, {"name": "Two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p4p_p"]}, "charge": -4, "formula": "C77H119N15O41", "compartment": "p", "id": "murein5p4p_p"}, {"name": "Two linked disacharide pentapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p5p_p"]}, 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