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"adp_c": 1.0}, "id": "ACGK", "gene_reaction_rule": "TM1784"}, {"subsystem": "Arginine Biosynthesis", "name": "N-acetylglutamate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGS"]}, "metabolites": {"glu__L_c": -1.0, "acglu_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "ACGS", "gene_reaction_rule": "TM1783"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-aceto-2-hydroxybutanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACHBS"]}, "metabolites": {"2ahbut_c": 1.0, "2obut_c": -1.0, "pyr_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "ACHBS", "gene_reaction_rule": "TM0548 and TM0549"}, {"subsystem": "Pyruvate Met", "name": "Acetate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACKr"]}, "metabolites": {"ac_c": -1.0, "actp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACKr", "gene_reaction_rule": "TM0274"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Acetolactate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACLS"]}, "metabolites": {"pyr_c": -2.0, "co2_c": 1.0, "h_c": -1.0, "alac__S_c": 1.0}, "id": "ACLS", "gene_reaction_rule": "TM0548 and TM0549"}, {"subsystem": "Fatty Acid Synthesis", "name": "Acetyl-CoA ACP transacylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOATAi"]}, "metabolites": {"acACP_c": 1.0, "ACP_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACOATA", "gene_reaction_rule": "TM0802"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONT"]}, "metabolites": {"icit_c": 1.0, "cit_c": -1.0}, "id": "ACONT", "gene_reaction_rule": "TM0291 and TM0292"}, {"subsystem": "Arginine Biosynthesis", "name": "Acetylornithine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "acg5sa_c": 1.0, "acorn_c": -1.0}, "id": "ACOTA", "gene_reaction_rule": "TM1785"}, {"subsystem": "Pantothenate and CoA Biosynthesis", "name": "Acyl-carrier protein synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACPS1"]}, "metabolites": {"coa_c": -1.0, "ACP_c": 1.0, "pap_c": 1.0, "h_c": 1.0, "apoACP_c": -1.0}, "id": "ACPS1", "gene_reaction_rule": "TM0692"}, {"subsystem": "Pyruvate Met", "name": "Acylphosphatase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACYP_2"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "actp_c": -1.0, "ac_c": 1.0, "h_c": 1.0}, "id": "ACYP_2", "gene_reaction_rule": "TM1564"}, {"subsystem": "Transport", "name": "Acetate reversible transport via proton symport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACt2r"]}, "metabolites": {"ac_c": 1.0, "h_e": -1.0, "ac_e": -1.0, "h_c": 1.0}, "id": "ACt2r", "gene_reaction_rule": ""}, {"subsystem": "Purine Metabolism", "name": "Adenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADA"]}, "metabolites": {"nh4_c": 1.0, "adn_c": -1.0, "h_c": -1.0, "h2o_c": -1.0, "ins_c": 1.0}, "id": "ADA", "gene_reaction_rule": "TM0936"}, {"subsystem": "Lysine Biosynthesis", "name": "E N-acetyl-L,L-diaminopimelate aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADAPAT"]}, "metabolites": {"nal2a6o_c": -1.0, "akg_c": 1.0, "glu__L_c": -1.0, "n6all26d_c": 1.0}, "id": "ADAPAT", "gene_reaction_rule": "TM1785"}, {"subsystem": "Folate Metabolism", "name": "4-aminobenzoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCL"]}, "metabolites": {"pyr_c": 1.0, "4adcho_c": -1.0, "h_c": 1.0, "4abz_c": 1.0}, "id": "ADCL", "gene_reaction_rule": ""}, {"subsystem": "Folate Metabolism", "name": "4-amino-4-deoxychorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCS"]}, "metabolites": {"glu__L_c": 1.0, "4adcho_c": 1.0, "chor_c": -1.0, "gln__L_c": -1.0}, "id": "ADCS", "gene_reaction_rule": ""}, {"subsystem": "Purine Metabolism", "name": "Adenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK1"]}, "metabolites": {"amp_c": -1.0, "adp_c": 2.0, "atp_c": -1.0}, "id": "ADK1", "gene_reaction_rule": "TM1479"}, {"subsystem": "Purine Metabolism", "name": "Adentylate kinase (GTP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK3"]}, "metabolites": {"gtp_c": -1.0, "gdp_c": 1.0, "amp_c": -1.0, "adp_c": 1.0}, "id": "ADK3", "gene_reaction_rule": "TM1689"}, {"subsystem": "Methionine Metabolism", "name": "Adenosylmethionine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADMDC"]}, "metabolites": {"amet_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ametam_c": 1.0}, "id": "ADMDC", "gene_reaction_rule": "TM0655"}, {"subsystem": "Purine Metabolism", "name": "Adenine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPT"]}, "metabolites": {"ppi_c": 1.0, "ade_c": -1.0, "amp_c": 1.0, "prpp_c": -1.0}, "id": "ADPT", "gene_reaction_rule": "TM1384"}, {"subsystem": "Purine Biosynthesis", "name": "Adenylsuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADSL1r"]}, "metabolites": {"fum_c": 1.0, "amp_c": 1.0, "dcamp_c": -1.0}, "id": "ADSL1r", "gene_reaction_rule": "TM1095"}, {"subsystem": "Purine Biosynthesis", "name": "Adenylosuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADSL2r"]}, "metabolites": {"25aics_c": -1.0, "fum_c": 1.0, "aicar_c": 1.0}, "id": "ADSL2r", "gene_reaction_rule": "TM1095"}, {"subsystem": "Purine Biosynthesis", "name": "Adenylosuccinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, 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"notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "TM1782"}, {"subsystem": "Methionine Metabolism", "name": "Adenosylhomocysteinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AHC"]}, "metabolites": {"hcys__L_c": 1.0, "h2o_c": -1.0, "ahcys_c": -1.0, "adn_c": 1.0}, "id": "AHCi", "gene_reaction_rule": "TM0172"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AHCYSNS_r"]}, "metabolites": {"ahcys_c": -1.0, "h2o_c": -1.0, "ade_c": 1.0, "rhcys_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "TM1129"}, {"subsystem": "Aminosugar Metabolism", "name": "Beta-N-acetylhexosaminidase, cytosol", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHEXASE3"]}, "metabolites": {"acgam_c": 2.0, "h2o_c": -1.0, "chtbs_c": -1.0}, "id": "AHEXASE3", "gene_reaction_rule": "TM0809"}, {"subsystem": "Thiamine Biosynthesis", "name": "4 amino 5 hydroxymethyl 2 methylpyrimidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHMMPS"]}, "metabolites": {"4ahmmp_c": 1.0, "pi_c": 1.0, "h_c": -2.0, "gcald_c": 1.0, "air_c": -1.0}, "id": "AHMMPS", "gene_reaction_rule": "TM0788"}, {"subsystem": "Methionine Metabolism", "name": "O acetylhomoserine  thiol  lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHSERL2"]}, "metabolites": {"hcys__L_c": 1.0, "ac_c": 1.0, "achms_c": -1.0, "h2s_c": -1.0, "h_c": 1.0}, "id": "AHSERL2", "gene_reaction_rule": "TM0882"}, {"subsystem": "Purine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AICARTi"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "10fthf_c": -1.0, "thf_c": 1.0}, "id": "AICART", "gene_reaction_rule": "TM1249"}, {"subsystem": "Purine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRCr"]}, "metabolites": {"co2_c": -1.0, "5aizc_c": 1.0, "h_c": 1.0, "air_c": -1.0}, "id": "AIRCr", "gene_reaction_rule": "TM0446 and TM0447"}, {"subsystem": "Folate Metabolism", "name": "Alkaline phosphatase  Dihydroneopterin ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKP1"]}, "metabolites": {"dhnpt_c": 1.0, "h2o_c": -3.0, "pi_c": 3.0, "h_c": 2.0, "ahdt_c": -1.0}, "id": "AKP1", "gene_reaction_rule": "TM0156"}, {"subsystem": "Peptidoglycan Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "TM0259"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": ""}, {"subsystem": "tRNA Metabolism", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "TM1396"}, {"subsystem": "Transport", "name": "L-alanine transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_e": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ALAabc", "gene_reaction_rule": "TM1139 and TM1138 and TM1136 and TM1135 and TM1137"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"glyald_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "glyc_c": 1.0}, "id": "ALCD19", "gene_reaction_rule": "TM0111 and TM0920"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alkaline phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALKP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "dhap_c": -1.0, "dha_c": 1.0}, "id": "ALKP", "gene_reaction_rule": "TM0156"}, {"subsystem": "Others", "name": "Aldose reductase (methylglyoxal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR2"]}, "metabolites": {"acetol_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0}, "id": "ALR2", "gene_reaction_rule": "TM0412"}, {"subsystem": "Starch Metabolism", "name": "Amylose hydrolysis by alpha-1,4-amylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMYLe"]}, "metabolites": {"h2o_e": -199.0, "malt_e": 100.0, "glc__D_e": 100.0, "amylose300_e": -1.0}, "id": "AMYLe", "gene_reaction_rule": "TM1840"}, {"subsystem": "Starch Metabolism", "name": "Starch hydrolysis by alpha-1,4-amylase and alpha-1,6 pullulanase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMYe"]}, "metabolites": {"starch1200_e": -1.0, "h2o_e": -499.0, "malttr_e": 300.0, "malt_e": 100.0, "glc__D_e": 100.0}, "id": "AMYe", "gene_reaction_rule": "TM1840 and TM1845"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Anthranilate phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANPRT"]}, "metabolites": {"anth_c": -1.0, "ppi_c": 1.0, "prpp_c": -1.0, "pran_c": 1.0}, "id": "ANPRT", "gene_reaction_rule": "TM0142 or TM0141"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Anthranilate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANS"]}, "metabolites": {"anth_c": 1.0, "pyr_c": 1.0, "chor_c": -1.0, "h_c": 1.0, "glu__L_c": 1.0, "gln__L_c": -1.0}, "id": "ANS", "gene_reaction_rule": "TM0141 or TM0142"}, {"subsystem": "Riboflavin Metabolism", "name": "5-amino-6-(5-phosphoribosylamino)uracil reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APRAUR"]}, "metabolites": {"5apru_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "5aprbu_c": 1.0}, "id": "APRAUR", "gene_reaction_rule": "TM1828"}, {"subsystem": "Arabinose Metabolism", "name": "L-arabinose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARAI"]}, "metabolites": {"rbl__L_c": 1.0, "arab__L_c": -1.0}, "id": "ARAI", "gene_reaction_rule": "TM0276"}, {"subsystem": "Transport", "name": "ARBabc", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "arab__L_e": -1.0, "arab__L_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "ARBabc", "gene_reaction_rule": ""}, {"subsystem": "Arginine Biosynthesis", "name": "Argininosuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGSL"]}, "metabolites": {"argsuc_c": -1.0, "fum_c": 1.0, "arg__L_c": 1.0}, "id": "ARGSL", "gene_reaction_rule": "TM1781"}, {"subsystem": "Arginine Biosynthesis", "name": "Argininosuccinate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGSSr"]}, "metabolites": {"atp_c": -1.0, "asp__L_c": -1.0, "ppi_c": 1.0, "argsuc_c": 1.0, "amp_c": 1.0, "citr__L_c": -1.0, "h_c": 1.0}, "id": "ARGSS", "gene_reaction_rule": "TM1780"}, {"subsystem": "tRNA Metabolism", "name": "Arginyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGTRS_r"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "argtrna_c": 1.0, "arg__L_c": -1.0, "amp_c": 1.0, "trnaarg_c": -1.0}, "id": "ARGTRS", "gene_reaction_rule": "TM1093"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "L-Arogenate hydro-lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AROH"]}, "metabolites": {"h2o_c": 1.0, "co2_c": 1.0, "Largn_c": -1.0, "phe__L_c": 1.0}, "id": "AROH", "gene_reaction_rule": "TM0155"}, {"subsystem": "Threonine Metabolism", "name": "Aspartate-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASAD"]}, "metabolites": {"aspsa_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "pi_c": -1.0, "4pasp_c": 1.0}, "id": "ASAD", "gene_reaction_rule": "TM1523"}, {"subsystem": "tRNA Metabolism", "name": "Aspartyl-tRNA(Asn) amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNTRAT"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "asntrna_c": 1.0, "asptrna_asn_c": -1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "ASNTRAT", "gene_reaction_rule": "TM1272 and TM1273 and TM0252"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Aspartate 1-decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASP1DC"]}, "metabolites": {"asp__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ala_B_c": 1.0}, "id": "ASP1DC", "gene_reaction_rule": "TM0939"}, {"subsystem": "Pyrimidine Biosynthesis", "name": "Aspartate carbamoyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPCT"]}, "metabolites": {"cbasp_c": 1.0, "asp__L_c": -1.0, "cbp_c": -1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "ASPCT", "gene_reaction_rule": "TM1642"}, {"subsystem": "Threonine Metabolism", "name": "Aspartate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPK"]}, "metabolites": {"asp__L_c": -1.0, "4pasp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ASPK", "gene_reaction_rule": "TM1518 or TM0547"}, {"subsystem": "NAD Metabolism", "name": "ASPO2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPO1_TM"]}, "metabolites": {"asp__L_c": -1.0, "iasp_c": 1.0, "nadh_c": 1.0, "h_c": 2.0, "nad_c": -1.0}, "id": "ASPO2", "gene_reaction_rule": "TM1643"}, {"subsystem": "Glutamate Metabolism", "name": "Aspartate transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPTA"]}, "metabolites": {"akg_c": -1.0, "asp__L_c": -1.0, "glu__L_c": 1.0, "oaa_c": 1.0}, "id": "ASPTA", "gene_reaction_rule": "TM1698 or TM1255"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "E L-alanine-alpha-keto acid aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPTA6"]}, "metabolites": {"asp__L_c": 1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "oaa_c": -1.0}, "id": "ASPTA6", "gene_reaction_rule": "TM1400"}, {"subsystem": "tRNA Metabolism", "name": "Aspartyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPTRS"]}, "metabolites": {"asptrna_c": 1.0, "atp_c": -1.0, "asp__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaasp_c": -1.0}, "id": "ASPTRS", "gene_reaction_rule": "TM1441"}, {"subsystem": "tRNA Metabolism", "name": "Aspartyl-tRNA synthetase (Asn)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPTRS_Asn"]}, "metabolites": {"trnaasn_c": -1.0, "atp_c": -1.0, "asp__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "asptrna_asn_c": 1.0}, "id": "ASPTRS_Asn", "gene_reaction_rule": "TM1441"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-aspartase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPT_rev"]}, "metabolites": {"asp__L_c": -1.0, "fum_c": 1.0, "nh4_c": 1.0}, "id": "ASPT", "gene_reaction_rule": "TM0444"}, {"subsystem": "Histidine Biosynthesis", "name": "ATP phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ATPPRTr"]}, "metabolites": {"ppi_c": 1.0, "prpp_c": -1.0, "atp_c": -1.0, "prbatp_c": 1.0}, "id": "ATPPRT", "gene_reaction_rule": "TM1042 and TM1043"}, {"subsystem": "Energy Metabolism", "name": "ATPS1", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPS1"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_e": 2.0, "h_c": -1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ATPS1", "gene_reaction_rule": "TM1612 and TM1616 and TM1609 and TM1610 and TM1615 and TM1614 and TM1611 and TM1613"}, {"subsystem": "Energy Metabolism", "name": "ATP synthase (10 protons for three ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPS10_3"]}, "metabolites": {"h2o_c": 3.0, "atp_c": 3.0, "h_e": -10.0, "h_c": 7.0, "adp_c": -3.0, "pi_c": -3.0}, "id": "ATPS10_3", "gene_reaction_rule": "TM1612 and TM1616 and TM1609 and TM1610 and TM1615 and TM1614 and TM1611 and TM1613"}, {"subsystem": "Energy Metabolism", "name": "ATP synthase (four protons for one ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPS4"]}, "metabolites": {"h2o_c": 1.0, "atp_c": 1.0, "h_e": -4.0, "h_c": 3.0, "adp_c": -1.0, "pi_c": -1.0}, "id": "ATPS4r", "gene_reaction_rule": "TM1612 and TM1616 and TM1609 and TM1610 and TM1615 and TM1614 and TM1611 and TM1613"}, {"subsystem": "Biotin Biosynthesis", "name": "Biotin acetyl CoA carboxylase ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BACCL"]}, "metabolites": {"btamp_c": 1.0, "ppi_c": 1.0, "btn_c": -1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "BACCL", "gene_reaction_rule": "TM0224"}, {"subsystem": "Carbohydrate Metabolism", "name": "Beta-glucosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BGLA"]}, "metabolites": {"glc__D_c": 2.0, "h2o_c": -1.0, "cellb_c": -1.0}, "id": "BGLA", "gene_reaction_rule": "TM0025 or TM0076"}, {"subsystem": "Cellulose Metabolism", "name": "6-phospho-beta-glucosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BGLA1"]}, "metabolites": {"glc__D_c": 1.0, "g6p_c": 1.0, "6pgg_c": -1.0, "h2o_c": -1.0}, "id": "BGLA1", "gene_reaction_rule": "TM1281"}, {"subsystem": "Biotin Biosynthesis", "name": "Biotin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BTS3"]}, "metabolites": {"s_c": -2.0, "btn_c": 1.0, "dtbt_c": -1.0, "h2s_c": 1.0}, "id": "BTS3r", "gene_reaction_rule": "TM1269"}, {"subsystem": "Butanoate Metabolism", "name": "Butyrate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BUTK"]}, "metabolites": {"but_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "butpi_c": 1.0}, "id": "BUTKr", "gene_reaction_rule": "TM1754 or TM1756"}, {"subsystem": "Fatty Acid Synthesis", "name": "Fatty acid biosynthesis (n-C10:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["C100SN"]}, "metabolites": {"dcaACP_c": 1.0, "nadp_c": 8.0, "nadph_c": -8.0, "ACP_c": 3.0, "malACP_c": -3.0, "h2o_c": 4.0, "h_c": -11.0, "actACP_c": -1.0, "co2_c": 3.0}, "id": "C100SN", "gene_reaction_rule": "TM0798 and TM0802 and (TM1724 or TM1169) and TM0800 and TM0801"}, {"subsystem": "Pyrimidine Biosynthesis", "name": "Carbamoyl-phosphate synthase (glutamine-hydrolysing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBPS"]}, "metabolites": {"cbp_c": 1.0, "atp_c": -2.0, "hco3_c": -1.0, "glu__L_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "adp_c": 2.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "CBPS", "gene_reaction_rule": "TM0558 and TM0557"}, {"subsystem": "Terpenoid biosynthesis", "name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPMEK"]}, "metabolites": {"2p4c2me_c": 1.0, "4c2me_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "CDPMEK", "gene_reaction_rule": "TM1383"}, {"subsystem": "Transport", "name": "Oligo-cellulose (6) transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CEL6abc"]}, "metabolites": {"cell6_e": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cell6_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CEL6abc", "gene_reaction_rule": "TM1226 and TM1222 and TM1221 and TM1220 and TM1219"}, {"subsystem": "Cellulose Metabolism", "name": "Celluase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CELASE1"]}, "metabolites": {"cell4_c": -1.0, "h2o_c": -1.0, "cellb_c": 2.0}, "id": "CELASE1", "gene_reaction_rule": "TM1524"}, {"subsystem": "Cellulose Metabolism", "name": "Celluase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CELASE2"]}, "metabolites": {"h2o_c": -2.0, "cellb_c": 3.0, "cell6_c": -1.0}, "id": "CELASE2", "gene_reaction_rule": "TM1524"}, {"subsystem": "Transport", "name": "Cellobiose transport via ATP transporter", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CELLBabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cellb_c": 1.0, "cellb_e": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CELLBabc", "gene_reaction_rule": "(TM0031 and TM0030 and TM0029 and TM0028 and TM0027) or (TM1226 and TM1222 and TM1221 and TM1220 and TM1219)"}, {"subsystem": "Transport", "name": "Oligo-cellulose transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CELabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cell4_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "cell4_e": -1.0, "pi_c": 1.0}, "id": "CELabc", "gene_reaction_rule": "TM1226 and TM1222 and TM1221 and TM1220 and TM1219"}, {"subsystem": "Cellulose Metabolism", "name": "Cellobiose phosphorylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CEPA"]}, "metabolites": {"glc__D_c": 1.0, "cellb_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0}, "id": "CEPA", "gene_reaction_rule": "TM1848"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Chorismate mutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CHORMr"]}, "metabolites": {"chor_c": -1.0, "pphn_c": 1.0}, "id": "CHORM", "gene_reaction_rule": "TM0155"}, {"subsystem": "Chorismate Biosynthesis", "name": "Chorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORS"]}, "metabolites": {"chor_c": 1.0, "pi_c": 1.0, "3psme_c": -1.0}, "id": "CHORS", "gene_reaction_rule": "TM0347"}, {"subsystem": "Transport", "name": "CO2 transporter via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CO2t"]}, "metabolites": {"co2_c": 1.0, "co2_e": -1.0}, "id": "CO2t", "gene_reaction_rule": "S_0001"}, {"subsystem": "Others", "name": "Creatinine amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRTNh"]}, "metabolites": {"crtn_c": -1.0, "h2o_c": -1.0, "creat_c": 1.0}, "id": "CRTNh", "gene_reaction_rule": "TM0413"}, {"subsystem": "Others", "name": "CRTNsyn", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRTNsyn"]}, "metabolites": {"crtn_c": 1.0, "pi_c": 1.0, "h_c": 1.0, "pcreat_c": -1.0}, "id": "CRTNsyn", "gene_reaction_rule": "S_0001"}, {"subsystem": "Citric Acid Cycle", "name": "Citrate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CS"]}, "metabolites": {"h2o_c": -1.0, "oaa_c": -1.0, "cit_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "CS", "gene_reaction_rule": "TM0290"}, {"subsystem": "Transport", "name": "Cytosine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CSNt2"]}, "metabolites": {"csn_c": 1.0, "h_e": -1.0, "h_c": 1.0, "csn_e": -1.0}, "id": "CSNt2", "gene_reaction_rule": ""}, {"subsystem": "Pyrimidine Metabolism", "name": "CTP synthase (glutamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTPS2"]}, "metabolites": {"utp_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "ctp_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "CTPS2", "gene_reaction_rule": "TM0803"}, {"subsystem": "Cysteine Metabolism", "name": "Cysteine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSS"]}, "metabolites": {"cys__L_c": 1.0, "ac_c": 1.0, "acser_c": -1.0, "h_c": 1.0, "h2s_c": -1.0}, "id": "CYSS", "gene_reaction_rule": "TM0665 or TM0882"}, {"subsystem": "Cysteine Metabolism", "name": "Cysteine transaminase irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSTAi"]}, "metabolites": {"akg_c": 1.0, "cys__L_c": 1.0, "glu__L_c": -1.0, "mercppyr_c": -1.0}, "id": "CYSTAi", "gene_reaction_rule": "TM1698 or TM1255"}, {"subsystem": "tRNA Metabolism", "name": "Cysteinyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSTRS"]}, "metabolites": {"cys__L_c": -1.0, "atp_c": -1.0, "cystrna_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnacys_c": -1.0}, "id": "CYSTRS", "gene_reaction_rule": "TM1410 or TM0719"}, {"subsystem": "Pyrimidine Metabolism", "name": "Cytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTD"]}, "metabolites": {"cytd_c": -1.0, "uri_c": 1.0, "h2o_c": -1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "CYTD", "gene_reaction_rule": "TM0846"}, {"name": "Deoxycytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "h_c": -1.0, "duri_c": 1.0, "nh4_c": 1.0}, "id": "DCYTD", "gene_reaction_rule": "TM0846"}, {"subsystem": "Pyrimidine Metabolism", "name": "Cytidine kinase (GTP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDK2"]}, "metabolites": {"cytd_c": -1.0, "gtp_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "cmp_c": 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"Diaminopimelate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPDC"]}, "metabolites": {"co2_c": 1.0, "lys__L_c": 1.0, "h_c": -1.0, "26dap__M_c": -1.0}, "id": "DAPDC", "gene_reaction_rule": "TM1517"}, {"subsystem": "Lysine Biosynthesis", "name": "Diaminopimelate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPE"]}, "metabolites": {"26dap_LL_c": -1.0, "26dap__M_c": 1.0}, "id": "DAPE", "gene_reaction_rule": "TM1522"}, {"subsystem": "Lipid Biosynthesis", "name": "CDP-diacylglycerol synthetase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN160"]}, "metabolites": {"ctp_c": -1.0, "pa160_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "cdpdhdecg_c": 1.0}, "id": "DASYN160", "gene_reaction_rule": "TM1397"}, {"subsystem": "Riboflavin Metabolism", "name": "3,4-Dihydroxy-2-butanone-4-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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-1.0, "pi_c": 1.0, "2dda7p_c": 1.0, "h2o_c": -1.0}, "id": "DDPA", "gene_reaction_rule": "TM0343"}, {"subsystem": "Entner-Doudoroff pathway", "name": "DDPGA", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDPGA"]}, "metabolites": {"pyr_c": 1.0, "glx_c": 1.0, "4h2oglt_c": -1.0}, "id": "DDPGA", "gene_reaction_rule": "(TM0128 and TM0880) or TM0066"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD1"]}, "metabolites": {"h2o_c": 1.0, "23dhmb_c": -1.0, "3mob_c": 1.0}, "id": "DHAD1", "gene_reaction_rule": "TM0551"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD2"]}, "metabolites": {"23dhmp_c": -1.0, "3mop_c": 1.0, "h2o_c": 1.0}, "id": "DHAD2", "gene_reaction_rule": "TM0551"}, {"subsystem": "Lysine Biosynthesis", "name": "Dihydrodipicolinate reductase (NADH) reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHDPRx_r"]}, "metabolites": {"thdp_c": 1.0, "23dhdp_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "DHDPRx_r", "gene_reaction_rule": "TM1520"}, {"subsystem": "Lysine Biosynthesis", "name": "Dihydrodipicolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPS"]}, "metabolites": {"aspsa_c": -1.0, "pyr_c": -1.0, "23dhdp_c": 1.0, "h_c": 1.0, "h2o_c": 2.0}, "id": "DHDPS", "gene_reaction_rule": "TM1521"}, {"subsystem": "Folate Metabolism", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"dhf_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "thf_c": 1.0}, "id": "DHFR", "gene_reaction_rule": "TM1641"}, {"subsystem": "Folate Metabolism", "name": "Dihydrofolate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHFS"]}, "metabolites": {"dhf_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "dhpt_c": -1.0, "pi_c": 1.0}, "id": "DHFS", "gene_reaction_rule": "TM0166"}, {"subsystem": "Folate Metabolism", "name": "DHNPA", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNPA"]}, "metabolites": {"gcald_c": 1.0, "dhnpt_c": -1.0, "h_c": 1.0, "2ahhmp_c": 1.0}, "id": "DHNPA", "gene_reaction_rule": ""}, {"subsystem": "Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORD__NAD"]}, "metabolites": {"nadh_c": 1.0, "dhor__S_c": -1.0, "nad_c": -1.0, "orot_c": 1.0}, "id": "DHORD_NAD", "gene_reaction_rule": "TM0333 and TM0334"}, {"subsystem": "Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "TM0335"}, {"subsystem": "Riboflavin Metabolism", "name": "Diaminohydroxyphosphoribosylaminopyrimidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA"]}, "metabolites": {"5apru_c": 1.0, "h2o_c": -1.0, "h_c": -1.0, "25dhpp_c": -1.0, "nh4_c": 1.0}, "id": "DHPPDA", "gene_reaction_rule": "TM1828"}, {"subsystem": "Chorismate Biosynthesis", "name": "3-dehydroquinate dehydratase, irreversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHQD"]}, "metabolites": {"3dhsk_c": 1.0, "h2o_c": 1.0, "3dhq_c": -1.0}, "id": "DHQTi", "gene_reaction_rule": "TM0349"}, {"subsystem": "Chorismate Biosynthesis", "name": "3-dehydroquinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQS"]}, "metabolites": {"2dda7p_c": -1.0, "pi_c": 1.0, "3dhq_c": 1.0}, "id": "DHQS", "gene_reaction_rule": "TM0348"}, {"subsystem": "Terpenoid biosynthesis", "name": "Dimethylallyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMATT"]}, "metabolites": {"dmpp_c": -1.0, "ppi_c": 1.0, "ipdp_c": -1.0, "grdp_c": 1.0}, "id": "DMATT", "gene_reaction_rule": "TM0161"}, {"subsystem": "Folate Metabolism", "name": "Dihydroneopterin monophosphate dephosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DNMPPA"]}, "metabolites": {"h2o_c": -1.0, "dhnpt_c": 1.0, "pi_c": 1.0, "dhpmp_c": -1.0}, "id": "DNMPPA", "gene_reaction_rule": "TM0317"}, {"subsystem": "Folate Metabolism", "name": "Dihydroneopterin triphosphate pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DNTPPA"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "ppi_c": 1.0, "dhpmp_c": 1.0, "ahdt_c": -1.0}, "id": "DNTPPA", "gene_reaction_rule": "TM0317"}, {"subsystem": "Pantothenate and CoA Metabolism", "name": "Dephospho-CoA kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPCOAK"]}, "metabolites": {"dpcoa_c": -1.0, "coa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "DPCOAK", "gene_reaction_rule": "TM1387"}, {"subsystem": "Pantothenate and CoA Metabolism", "name": "2-dehydropantoate 2-reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPR"]}, "metabolites": {"pant__R_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhp_c": -1.0}, "id": "DPR", "gene_reaction_rule": "TM0550"}, {"subsystem": "Ribose Metabolism", "name": "Deoxyribokinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DRBKr"]}, "metabolites": {"adp_c": 1.0, "h_c": 1.0, "2dr5p_c": 1.0, "atp_c": -1.0, "drib_c": -1.0}, "id": "DRBK", "gene_reaction_rule": "TM0960"}, {"subsystem": "Energy Metabolism", "name": "Deoxyribose-phosphate aldolase", 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""}, {"subsystem": "Lipid Biosynthesis", "name": "Synthesis of 15,16-Dimethyltriacontanedioic acid (C32:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FASC320"]}, "metabolites": {"dmtaACP_c": 1.0, "ACP_c": 1.0, "palmACP_c": -2.0}, "id": "FASC320", "gene_reaction_rule": ""}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose-bisphosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FBA"]}, "metabolites": {"dhap_c": 1.0, "g3p_c": 1.0, "fdp_c": -1.0}, "id": "FBA", "gene_reaction_rule": "TM0273"}, {"subsystem": "Carbohydrate Metabolism", "name": "D Fructose 1 phosphate D glyceraldehyde 3 phosphate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FBA2"]}, "metabolites": {"f1p_c": -1.0, "dhap_c": 1.0, "glyald_c": 1.0}, "id": "FBA2", "gene_reaction_rule": "TM0273"}, {"subsystem": "Carbohydrate Metabolism", "name": "Sedoheptulose 1,7-bisphosphate 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"fe3_e": -1.0, "pi_c": 1.0}, "id": "FE3abc", "gene_reaction_rule": "(TM0191 and TM0189 and TM0190) or (TM0078 and TM0080 and TM0079)"}, {"subsystem": "Energy Metabolism", "name": "Quinon:iron(III) oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FERIRDe"]}, "metabolites": {"qh2_c": -1.0, "h_e": 2.0, "q_c": 1.0, "fe2_e": 2.0, "fe3_e": -2.0}, "id": "FERIRDe", "gene_reaction_rule": ""}, {"subsystem": "tRNA Metabolism", "name": "Methionyl-tRNA formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMETTRS"]}, "metabolites": {"thf_c": 1.0, "mettrna_c": -1.0, "10fthf_c": -1.0, "fmettrna_c": 1.0, "h_c": 1.0}, "id": "FMETTRS", "gene_reaction_rule": "TM0528"}, {"subsystem": "Riboflavin Metabolism", "name": "FMN adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMNAT"]}, "metabolites": {"ppi_c": 1.0, "fmn_c": -1.0, "fad_c": 1.0, "atp_c": -1.0, "h_c": -1.0}, "id": "FMNAT", "gene_reaction_rule": "TM0857"}, {"subsystem": "Folate Metabolism", "name": "FOLD3", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FOLD3"]}, "metabolites": {"dhpt_c": 1.0, "2ahhmd_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "FOLD3", "gene_reaction_rule": "TM0040"}, {"subsystem": "Folate Metabolism", "name": "Folylpolyglutamate synthetase TM", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FPGS_tm"]}, "metabolites": {"atp_c": -4.0, "thfglu_c": 1.0, "glu__L_c": -4.0, "thf_c": -1.0, "adp_c": 4.0, "pi_c": 4.0, "h_c": 4.0}, "id": "FPGS_tm", "gene_reaction_rule": "TM0166"}, {"subsystem": "Carbohydrate Metabolism", "name": "Fructose-1-phosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUK_r"]}, "metabolites": {"h_c": 1.0, "f1p_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "fdp_c": 1.0}, "id": "FRUK", "gene_reaction_rule": "TM0828"}, {"subsystem": "Transport", "name": "Fructose 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"name": "Galactokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALK"]}, "metabolites": {"gal_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "gal1p_c": 1.0, "adp_c": 1.0}, "id": "GALKr", "gene_reaction_rule": "TM1190"}, {"subsystem": "Carbohydrate Metabolism", "name": "Aldose 1-epimerase (glucose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALM1"]}, "metabolites": {"glc__D_c": 1.0, "glc_bD_c": -1.0}, "id": "GALM1", "gene_reaction_rule": "TM0282"}, {"subsystem": "Carbohydrate Metabolism", "name": "Aldose 1-epimerase (galactose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALM2"]}, "metabolites": {"gal_c": 1.0, "gal_bD_c": -1.0}, "id": "GALM2", "gene_reaction_rule": "TM0282"}, {"subsystem": "Mannan Metabolism", "name": "Hydrolysis of galactomannan", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALMAN4"]}, "metabolites": {"galman4_c": -1.0, "h2o_c": -3.0, "gal_c": 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["GARFTi"]}, "metabolites": {"gar_c": -1.0, "10fthf_c": -1.0, "fgam_c": 1.0, "h_c": 1.0, "thf_c": 1.0}, "id": "GARFT", "gene_reaction_rule": "TM1248"}, {"name": "Glutamate dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GDH1"]}, "metabolites": {"akg_c": 1.0, "h2o_c": -1.0, "nh3_c": 1.0, "glu__L_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "GDH1", "gene_reaction_rule": ""}, {"subsystem": "Aminosugar Metabolism", "name": "Glutamine-fructose-6-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GF6PTA"]}, "metabolites": {"gam6p_c": 1.0, "gln__L_c": -1.0, "glu__L_c": 1.0, "f6p_c": -1.0}, "id": "GF6PTA", "gene_reaction_rule": "TM0148"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine hydroxymethyltransferase, reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHMT2r"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, 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"gene_reaction_rule": "TM0305 and TM1227"}, {"subsystem": "Mannan Metabolism", "name": "Hydrolysis of glucomannan (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCMAN600b(e)"]}, "metabolites": {"h2o_e": -99.0, "glcman600_e": -1.0, "glcman6_e": 100.0}, "id": "GLCMAN600b_e", "gene_reaction_rule": "TM0305 and TM1227"}, {"subsystem": "Mannan Metabolism", "name": "Hydrolysis of glucomannan (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCMAN600c(e)"]}, "metabolites": {"glcman4_e": 75.0, "h2o_e": -124.0, "glcman600_e": -1.0, "glcman6_e": 50.0}, "id": "GLCMAN600c_e", "gene_reaction_rule": "TM0305 and TM1227"}, {"subsystem": "Transport", "name": "Glucomannan transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCMAN6abc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glcman6_c": 1.0, "glcman6_e": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLCMAN6abc", "gene_reaction_rule": "TM1746 and TM1747 and TM1748 and TM1749 and TM1750"}, {"subsystem": "Glycogene synthesis", "name": "Glycogen synthase (ADPGlc)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCS1"]}, "metabolites": {"glycogen_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "adpglc_c": -1.0}, "id": "GLCS1", "gene_reaction_rule": "TM0895"}, {"subsystem": "Xylan Metabolism", "name": "Alpha-glucuronidase, de-branching xylan", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURS1"]}, "metabolites": {"xylan4_c": -1.0, "xyl4_c": 1.0, "h2o_c": -1.0, "glcur_c": 1.0}, "id": "GLCURS1", "gene_reaction_rule": "TM0055 or TM0434"}, {"subsystem": "Galactose metabolism", "name": "Glucuronosyltransferase (tryptophanyl)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURT"]}, "metabolites": {"udp_c": 1.0, "trp__L_c": -1.0, "udpglcur_c": -1.0, "trpglcur_c": 1.0}, "id": "GLCURT", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "GLCabc", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "glc__D_c": 1.0, "pi_c": 1.0, "glc__D_e": -1.0}, "id": "GLCabc", "gene_reaction_rule": "TM1204 and TM1203 and TM1202"}, {"subsystem": "Glycogene synthesis", "name": "Glucose-1-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLGC"]}, "metabolites": {"ppi_c": 1.0, "g1p_c": -1.0, "adpglc_c": 1.0, "atp_c": -1.0, "h_c": -1.0}, "id": "GLGC", "gene_reaction_rule": "TM0240 or TM0239"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "TM0943"}, {"subsystem": "Peptidoglycan Biosynthesis", "name": "GLNSP2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNSP2"]}, "metabolites": {"atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "uaaGgtla_c": 1.0, "uaaGgla_c": -1.0}, "id": "GLNSP2", "gene_reaction_rule": "TM0943"}, {"subsystem": "tRNA Metabolism", "name": "GLNTRAT", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRAT"]}, "metabolites": {"glutrna_gln_c": -1.0, "h2o_c": -1.0, "glntrna_c": 1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRAT", "gene_reaction_rule": "TM1272 and TM1273 and TM0252"}, {"subsystem": "Glucan Metabolism", "name": "Glucan hydrolysis by beta-1,4- and beta-1,3 glucosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLS"]}, "metabolites": {"glc__D_c": 4.0, "h2o_c": -3.0, "glucan4_c": -1.0}, "id": "GLS", "gene_reaction_rule": "TM0024 or 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"GLUFT", "gene_reaction_rule": "TM0843"}, {"subsystem": "Purine Biosynthesis", "name": "Glutamine phosphoribosyldiphosphate amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUPRT"]}, "metabolites": {"pram_c": 1.0, "h2o_c": -1.0, "ppi_c": 1.0, "glu__L_c": 1.0, "prpp_c": -1.0, "gln__L_c": -1.0}, "id": "GLUPRT", "gene_reaction_rule": "TM1247"}, {"subsystem": "Glutamate and glutamin metabolism", "name": "Glutamate racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUR"]}, "metabolites": {"glu__L_c": 1.0, "glu__D_c": -1.0}, "id": "GLUR", "gene_reaction_rule": ""}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate synthase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUSy"]}, "metabolites": {"akg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "glu__L_c": 2.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLUSy", "gene_reaction_rule": "TM0397 and (TM1217 or TM1640)"}, {"subsystem": "tRNA Metabolism", "name": "Glutamyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "trnaglu_c": -1.0, "amp_c": 1.0, "glutrna_c": 1.0, "ppi_c": 1.0}, "id": "GLUTRS", "gene_reaction_rule": "TM1875 or TM1351"}, {"subsystem": "tRNA Metabolism", "name": "GLUTRS Gln ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRS_Gln"]}, "metabolites": {"glutrna_gln_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "glu__L_c": -1.0, "amp_c": 1.0, "ppi_c": 1.0}, "id": "GLUTRS_Gln", "gene_reaction_rule": "TM1875 or TM1351"}, {"subsystem": "Transport", "name": "Sn-Glycerol 3-phosphate transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pabc"]}, "metabolites": {"glyc3p_c": 1.0, "glyc3p_e": -1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLYC3Pabc", "gene_reaction_rule": "TM1121 and TM1120 and TM1122"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCD_r"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "dha_c": 1.0, "glyc_c": -1.0}, "id": "GLYCDx", "gene_reaction_rule": "TM0423"}, {"subsystem": "Others", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK2"]}, "metabolites": {"2pg_c": 1.0, "glyc__R_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GLYCK2", "gene_reaction_rule": "TM1585"}, {"subsystem": "Folate Metabolism", "name": "GLYCL 2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCL_2"]}, "metabolites": {"nadh_c": -1.0, "mlthf_c": -1.0, "gly_c": 1.0, "thf_c": 1.0, "nad_c": 1.0, "co2_c": -1.0, "nh4_c": -1.0}, "id": "GLYCL_2", "gene_reaction_rule": "TM0211"}, {"subsystem": "Glycogen Metabolism", "name": "Glycogen hydrolysis 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"metabolites": {"6pgc_c": -1.0, "nadph_c": 1.0, "nadp_c": -1.0, "co2_c": 1.0, "ru5p__D_c": 1.0}, "id": "GND", "gene_reaction_rule": "TM0438"}, {"subsystem": "Entner-Doudoroff pathway", "name": "Gluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GNK"]}, "metabolites": {"6pgc_c": 1.0, "glcn_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GNK", "gene_reaction_rule": "TM0443"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA1"]}, "metabolites": {"chol_c": 1.0, "glyc3p_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "g3pc_c": -1.0}, "id": "GPDDA1", "gene_reaction_rule": "TM1621"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA2"]}, 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["HCO3E"]}, "metabolites": {"hco3_c": 1.0, "h2o_c": -1.0, "co2_c": -1.0, "h_c": 1.0}, "id": "HCO3E", "gene_reaction_rule": "S_0001"}, {"subsystem": "Transport", "name": "Bicarbonate transport via ABC", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HCO3abc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "hco3_c": 1.0, "hco3_e": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "HCO3abc", "gene_reaction_rule": "TM0202 and TM0204 and TM0203"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Hexokinase (D-glucose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX1"]}, "metabolites": {"glc__D_c": -1.0, "g6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HEX1", "gene_reaction_rule": "TM1469"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-mannose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX4"]}, "metabolites": {"h_c": 1.0, "man6p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "man_c": -1.0}, "id": "HEX4", "gene_reaction_rule": ""}, {"subsystem": "Carbohydrate Metabolism", "name": "Hexokinase (D-fructose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX7"]}, "metabolites": {"h_c": 1.0, "fru_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "f6p_c": 1.0}, "id": "HEX7", "gene_reaction_rule": "TM0296"}, {"subsystem": "Histidine Biosynthesis", "name": "Histidinol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTD"]}, "metabolites": {"histd_c": -1.0, "h2o_c": -1.0, "his__L_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "HISTD", "gene_reaction_rule": "TM1041"}, {"subsystem": "Histidine Biosynthesis", "name": "Histidinol-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTP"]}, "metabolites": {"hisp_c": -1.0, "histd_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "HISTP", "gene_reaction_rule": "TM0804"}, {"subsystem": "tRNA Metabolism", "name": "Histidyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTRS"]}, "metabolites": {"histrna_c": 1.0, "atp_c": -1.0, "his__L_c": -1.0, "ppi_c": 1.0, "trnahis_c": -1.0, "amp_c": 1.0}, "id": "HISTRS", "gene_reaction_rule": "TM1090"}, {"subsystem": "Thiamine Biosynthesis", "name": "Hydroxymethylpyrimidine kinase (ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMPK1"]}, "metabolites": {"adp_c": 1.0, "4ampm_c": 1.0, "4ahmmp_c": -1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HMPK1", "gene_reaction_rule": "TM0790"}, {"subsystem": "Folate Metabolism", "name": "HPPK", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPPK"]}, "metabolites": {"2ahhmd_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "2ahhmp_c": -1.0, "amp_c": 1.0}, "id": "HPPK", "gene_reaction_rule": "TM0041"}, {"subsystem": "Proline Biosynthesis", "name": "L hydroxyproline reductase  NADP ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPROb"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "1p3h5c_c": -1.0, "h_c": -2.0, "4hpro_LT_c": 1.0}, "id": "HPROb", "gene_reaction_rule": "TM0578"}, {"subsystem": "Threonine Metabolism", "name": "Homoserine dehydrogenase (NADPH)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HSDy"]}, "metabolites": {"hom__L_c": -1.0, "aspsa_c": 1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "HSDy", "gene_reaction_rule": "TM0547"}, {"subsystem": "Methionine Metabolism", "name": "Homoserine O trans acetylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HSERTA"]}, "metabolites": {"hom__L_c": -1.0, "coa_c": 1.0, "achms_c": 1.0, "accoa_c": -1.0}, "id": "HSERTA", "gene_reaction_rule": "TM0881"}, {"subsystem": "Threonine Metabolism", "name": "Homoserine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSK"]}, "metabolites": {"hom__L_c": -1.0, "phom_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HSK", "gene_reaction_rule": "TM0545"}, {"subsystem": "Histidine Biosynthesis", "name": "Histidinol-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HSTPTr"]}, "metabolites": {"akg_c": 1.0, "hisp_c": 1.0, "glu__L_c": -1.0, "imacp_c": -1.0}, "id": "HSTPT", "gene_reaction_rule": "TM1040"}, {"subsystem": "Purine Metabolism", "name": "Hypoxanthine phosphoribosyltransferase (Hypoxanthine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HXPRT"]}, "metabolites": {"ppi_c": 1.0, "imp_c": 1.0, "prpp_c": -1.0, "hxan_c": -1.0}, "id": "HXPRT", "gene_reaction_rule": "TM0206"}, {"subsystem": "Energy Metabolism", "name": "Ferredoxin NADH linked hydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYDFDN"]}, "metabolites": {"h2_c": 2.0, "fdxr_4_2_c": -1.0, "h_c": -3.0, "nad_c": 1.0, "nadh_c": -1.0, "fdxo_4_2_c": 1.0}, "id": "HYDFDN", "gene_reaction_rule": "TM1426 and TM1425 and TM1424"}, {"subsystem": "Citric Acid Cycle", "name": "Isocitrate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICDHyr"]}, "metabolites": {"akg_c": 1.0, "nadph_c": 1.0, "icit_c": -1.0, "co2_c": 1.0, "nadp_c": -1.0}, "id": "ICDHyr", "gene_reaction_rule": "TM1148"}, {"subsystem": "Histidine Biosynthesis", "name": "Imidazole-glycerol-3-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IG3PS"]}, "metabolites": {"aicar_c": 1.0, "glu__L_c": 1.0, "eig3p_c": 1.0, "h_c": 1.0, "prlp_c": -1.0, "gln__L_c": -1.0}, "id": "IG3PS", "gene_reaction_rule": "TM1036 and TM1038"}, {"subsystem": "Histidine Biosynthesis", "name": "Imidazoleglycerol-phosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPDH"]}, "metabolites": {"h2o_c": 1.0, "imacp_c": 1.0, "eig3p_c": -1.0}, "id": "IGPDH", "gene_reaction_rule": "TM1039"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Indole-3-glycerol-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPS"]}, "metabolites": {"h2o_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "2cpr5p_c": -1.0, "3ig3p_c": 1.0}, "id": "IGPS", "gene_reaction_rule": "TM0140"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Isoleucine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILETA"]}, "metabolites": {"akg_c": -1.0, "ile__L_c": -1.0, "glu__L_c": 1.0, "3mop_c": 1.0}, "id": "ILETA", "gene_reaction_rule": "TM0831"}, {"subsystem": "tRNA Metabolism", "name": "Isoleucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILETRS"]}, "metabolites": {"iletrna_c": 1.0, "trnaile_c": -1.0, "atp_c": -1.0, "ile__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0}, "id": "ILETRS", "gene_reaction_rule": "TM1361"}, {"subsystem": "Transport", "name": "L-isoleucine transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILEabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ile__L_c": 1.0, "ile__L_e": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ILEabc", "gene_reaction_rule": "TM1139 and TM1138 and TM1136 and TM1135 and TM1137"}, {"subsystem": "Inositol Metabolism", "name": "Myo-inositol 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "dip_d_d_c": 1.0, "pdip_d_d_c": -1.0}, "id": "IMP", "gene_reaction_rule": "TM1415"}, {"subsystem": "Purine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "TM1249"}, {"subsystem": "Inositol 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"lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUTA"]}, "metabolites": {"akg_c": -1.0, "leu__L_c": -1.0, "4mop_c": 1.0, "glu__L_c": 1.0}, "id": "LEUTA", "gene_reaction_rule": "TM0831"}, {"subsystem": "tRNA Metabolism", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "TM0168"}, {"subsystem": "Transport", "name": "L-leucine transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUabc"]}, "metabolites": {"leu__L_c": 1.0, "leu__L_e": -1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LEUabc", "gene_reaction_rule": "TM1139 and TM1138 and TM1136 and TM1135 and TM1137"}, {"subsystem": "Laminarine Metabolism", "name": "Laminaribiase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LMN2"]}, "metabolites": {"glc__D_c": 2.0, "h2o_c": -1.0, "lmn2_c": -1.0}, "id": "LMN2", "gene_reaction_rule": "TM0025 or TM0076"}, {"subsystem": "Transport", "name": "Laminoribiose transport via ABC-transporter", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LMN2abc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lmn2_e": -1.0, "lmn2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LMN2abc", "gene_reaction_rule": "(TM0031 and TM0030 and TM0029 and TM0028 and TM0027) or (TM1204 and TM1203 and TM1202)"}, {"subsystem": "Laminarine Metabolism", "name": "Laminarinase (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LMNe"]}, "metabolites": {"lmn2_e": 15.0, "lmn30_e": -1.0, "h2o_e": -14.0}, "id": "LMNe", "gene_reaction_rule": "TM0024"}, {"subsystem": "tRNA Metabolism", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "TM1705"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha glucosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALT"]}, "metabolites": {"glc__D_c": 2.0, "malt_c": -1.0, "h2o_c": -1.0}, "id": "MALT", "gene_reaction_rule": "TM1834"}, {"subsystem": "Transport", "name": "Maltotriose transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malttr_e": -1.0, "pi_c": 1.0, "malttr_c": 1.0}, "id": "MALTTRabc", "gene_reaction_rule": "(TM1839 and TM_1837 and TM1836) or (TM1204 and TM1203 and TM1202)"}, {"subsystem": "Transport", "name": "Maltotetraose transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltttr_e": -1.0, "maltttr_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "MALTTTRabc", "gene_reaction_rule": "TM1204 and TM1203 and TM1202"}, {"subsystem": "Transport", "name": "Maltose transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malt_c": 1.0, "pi_c": 1.0, "malt_e": -1.0}, "id": "MALTabc", "gene_reaction_rule": "(TM1204 and TM1203 and TM1202) or (TM1839 and TM_1837 and TM1836)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose-6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MAN6PI"]}, "metabolites": {"man6p_c": -1.0, "f6p_c": 1.0}, "id": "MAN6PI", "gene_reaction_rule": "TM0736"}, {"subsystem": "Mannan Metabolism", "name": "Mannase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANA1"]}, "metabolites": {"manb_c": -1.0, "h2o_c": -1.0, "man_c": 2.0}, "id": "MANA1", "gene_reaction_rule": "TM1624"}, {"subsystem": "Mannan Metabolism", "name": "Mannase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANA2"]}, "metabolites": {"h2o_c": -1.0, "mantr_c": -1.0, "manb_c": 1.0, "man_c": 1.0}, "id": "MANA2", "gene_reaction_rule": "TM1624"}, {"subsystem": "Mannan Metabolism", "name": "Mannase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANA3"]}, "metabolites": {"h2o_c": -1.0, "man_c": 1.0, "manttr_c": -1.0, "mantr_c": 1.0}, "id": "MANA3", "gene_reaction_rule": "TM1624"}, {"subsystem": "Glucuronate Metabolism", "name": "Mannonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANAO"]}, "metabolites": {"fruur_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "mana_c": -1.0}, "id": "MANAO", "gene_reaction_rule": "TM0068"}, {"subsystem": "Transport", "name": "Mannobiose transport via ABC transporter", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANBabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "manb_c": 1.0, "manb_e": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "MANBabc", "gene_reaction_rule": "(TM1223 and TM1222 and TM1221 and TM1220 and TM1219) or (TM1226 and TM1222 and TM1221 and TM1220 and TM1219)"}, {"subsystem": "Transport", "name": "Mannotriose transport via ABC transporter", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANTRabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "mantr_e": -1.0, "pi_c": 1.0, "mantr_c": 1.0}, "id": "MANTRabc", "gene_reaction_rule": "TM1226 and TM1222 and TM1221 and TM1220 and TM1219"}, {"subsystem": "Transport", "name": "Mannotetraose transport via ABC transporter", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANTTRabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "manttr_e": -1.0, "manttr_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "MANTTRabc", "gene_reaction_rule": "TM1226 and TM1222 and TM1221 and TM1220 and TM1219"}, {"subsystem": "Transport", "name": "Mannose transport via ABC transporter", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANabc"]}, "metabolites": {"man_e": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "man_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "MANabc", "gene_reaction_rule": ""}, {"subsystem": "Cysteine Metabolism", "name": "3-Mercaptolactate:NAD+ oxidoreductase irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCLORi"]}, "metabolites": {"nad_c": 1.0, "mercplac_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "mercppyr_c": -1.0}, "id": "MCLORi", "gene_reaction_rule": "TM1867"}, {"subsystem": "Fatty Acid Synthesis", "name": "Malonyl-CoA-ACP transacylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCOATA"]}, "metabolites": {"coa_c": 1.0, "malcoa_c": -1.0, "malACP_c": 1.0, "ACP_c": -1.0}, "id": "MCOATA", "gene_reaction_rule": "TM0798"}, {"subsystem": "Citric Acid Cycle", "name": "Malate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MDH"]}, "metabolites": {"mal__L_c": -1.0, "nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "oaa_c": 1.0}, "id": "MDH", "gene_reaction_rule": "TM1867"}, {"subsystem": "Pyruvate Met", "name": "Malic enzyme (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ME1"]}, "metabolites": {"nad_c": -1.0, "mal__L_c": -1.0, "co2_c": 1.0, "pyr_c": 1.0, "nadh_c": 1.0}, "id": "ME1", "gene_reaction_rule": "TM0542"}, {"subsystem": "Terpenoid biosynthesis", "name": "2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MECDPDH2"]}, "metabolites": {"2mecdp_c": -1.0, "h2o_c": 1.0, "nadh_c": -1.0, "h2mb4p_c": 1.0, "nad_c": 1.0}, "id": "MECDPDH2", "gene_reaction_rule": "TM0891"}, {"subsystem": "Terpenoid biosynthesis", "name": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MECDPS"]}, "metabolites": {"2mecdp_c": 1.0, "2p4c2me_c": -1.0, "cmp_c": 1.0}, "id": "MECDPS", "gene_reaction_rule": "TM0647"}, {"subsystem": "Transport", "name": "Melibiose transport via ABC system (import)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MELIBabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "melib_c": 1.0, "pi_c": 1.0, "melib_e": -1.0}, "id": "MELIBabc", "gene_reaction_rule": "TM1204 and TM1203 and TM1202"}, {"subsystem": "Terpenoid biosynthesis", "name": "2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MEPCT"]}, "metabolites": {"ctp_c": -1.0, "2me4p_c": -1.0, "ppi_c": 1.0, "4c2me_c": 1.0, "h_c": -1.0}, "id": "MEPCT", "gene_reaction_rule": "TM1393"}, {"subsystem": "Methionine Metabolism", "name": "Methionine adenosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METAT"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "met__L_c": -1.0, "amet_c": 1.0, "pi_c": 1.0}, "id": "METAT", "gene_reaction_rule": "TM1658"}, {"subsystem": "Methionine Metabolism", "name": "Metb1", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["METB1r"]}, "metabolites": {"cys__L_c": -1.0, "ac_c": 1.0, "achms_c": -1.0, "cyst__L_c": 1.0, "h_c": 1.0}, "id": "METB1", "gene_reaction_rule": "TM1270"}, {"subsystem": "Methionine Metabolism", "name": "Methionine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METS"]}, "metabolites": {"hcys__L_c": -1.0, "h_c": 1.0, "thf_c": 1.0, "met__L_c": 1.0, "5mthf_c": -1.0}, "id": "METS", "gene_reaction_rule": "(TM0268 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["MI1PS2"]}, "metabolites": {"g6p_c": -1.0, "mi1p__L_c": 1.0}, "id": "MI1PS2", "gene_reaction_rule": "TM1419"}, {"subsystem": "Maltose Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malt_c": 1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "TM1835 or TM_1438"}, {"subsystem": "Maltose Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "TM1835"}, {"subsystem": "Mannitol Metabolism", "name": "Mannitol dehydrogenase (fructose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLDH2"]}, "metabolites": {"mnl_c": -1.0, "nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "fru_c": 1.0}, "id": "MNLDH2", "gene_reaction_rule": "TM0298"}, {"subsystem": "Mannitol Metabolism", "name": "Mannitol dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLDHr"]}, "metabolites": {"mnl_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "man_c": 1.0}, "id": "MNLDHr", "gene_reaction_rule": "TM0298"}, {"subsystem": "Glucuronate Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNNHr"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "TM0069"}, {"subsystem": "Pantothenate and CoA Metabolism", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"h2o_c": -1.0, "2dhp_c": 1.0, "thf_c": 1.0, "mlthf_c": -1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "TM1728"}, {"subsystem": "Methionine Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"5mta_c": -1.0, "h2o_c": -1.0, "ade_c": 1.0, "5mtr_c": 1.0}, "id": "MTAN", "gene_reaction_rule": "TM1129"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": 1.0, "methf_c": -1.0, "h_c": 1.0}, "id": "MTHFC", "gene_reaction_rule": "TM1767"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "TM1767"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 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"Aminosugar Metabolism", "name": "Phosphoglucosamine mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGAMTi"]}, "metabolites": {"gam6p_c": -1.0, "gam1p_c": 1.0}, "id": "PGAMTi", "gene_reaction_rule": "TM0184"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Phosphoglycerate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGCD"]}, "metabolites": {"3php_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3pg_c": -1.0}, "id": "PGCD", "gene_reaction_rule": "TM0327"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PGI"]}, "metabolites": {"g6p_c": -1.0, "f6p_c": 1.0}, "id": "PGI", "gene_reaction_rule": "TM1385"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Phosphoglycerate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PGK"]}, "metabolites": {"adp_c": 1.0, "13dpg_c": 1.0, "atp_c": -1.0, "3pg_c": -1.0}, "id": "PGK", "gene_reaction_rule": "TM0689"}, {"subsystem": "Pentose Phosphate Pathway", "name": "6-phosphogluconolactonase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGL"]}, "metabolites": {"6pgc_c": 1.0, "h2o_c": -1.0, "6pgl_c": -1.0, "h_c": 1.0}, "id": "PGL", "gene_reaction_rule": "TM1154"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Phosphoglycerate mutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PGM"]}, "metabolites": {"2pg_c": -1.0, "3pg_c": 1.0}, "id": "PGM", "gene_reaction_rule": "TM1774 or TM1374"}, {"subsystem": "Carbohydrate Metabolism", "name": "Phosphoglucomutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PGMT"]}, "metabolites": {"g6p_c": 1.0, "g1p_c": -1.0}, "id": "PGMT", "gene_reaction_rule": ""}, {"subsystem": "Lipid Biosynthesis", "name": "Phosphatidylglycerol synthase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGSA160"]}, "metabolites": {"glyc3p_c": -1.0, "pgp160_c": 1.0, "cdpdhdecg_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "PGSA160", "gene_reaction_rule": "TM1861"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Phenylalanine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PHETA1"]}, "metabolites": {"akg_c": -1.0, "phpyr_c": 1.0, "glu__L_c": 1.0, "phe__L_c": -1.0}, "id": "PHETA1", "gene_reaction_rule": "TM1040 or (TM1698 or TM1255)"}, {"subsystem": "tRNA Metabolism", "name": "Phenylalanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PHETRS"]}, "metabolites": {"trnaphe_c": -1.0, "atp_c": -1.0, "phe__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "phetrna_c": 1.0}, "id": "PHETRS", "gene_reaction_rule": "TM0821 and TM0822"}, {"subsystem": "Transport", "name": "Phosphate transport via ABC 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phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMDPHT"]}, "metabolites": {"4r5au_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "5aprbu_c": -1.0}, "id": "PMDPHT", "gene_reaction_rule": ""}, {"subsystem": "Thiamine Biosynthesis", "name": "Phosphomethylpyrimidine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMPK"]}, "metabolites": {"4ampm_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "2mahmp_c": 1.0}, "id": "PMPK", "gene_reaction_rule": "TM0790"}, {"subsystem": "NAD Metabolism", "name": "Purine nucleoside phosphorylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PNP"]}, "metabolites": {"rnam_c": -1.0, "pi_c": -1.0, "h_c": 1.0, "r1p_c": 1.0, "ncam_c": 1.0}, "id": "PNP", "gene_reaction_rule": "TM1737 or TM1596"}, {"subsystem": "Pantothenate and CoA Metabolism", "name": "Pantothenate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PNTK"]}, 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"gsn_c": -1.0}, "id": "PUNP3", "gene_reaction_rule": "TM1737 or TM1596"}, {"subsystem": "Purine Metabolism", "name": "Purine-nucleoside phosphorylase (Deoxyguanosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP4"]}, "metabolites": {"dgsn_c": -1.0, "gua_c": 1.0, "pi_c": -1.0, "2dr1p_c": 1.0}, "id": "PUNP4", "gene_reaction_rule": "TM1737 or TM1596"}, {"subsystem": "Purine Metabolism", "name": "Purine-nucleoside phosphorylase (Inosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP5"]}, "metabolites": {"pi_c": -1.0, "hxan_c": 1.0, "r1p_c": 1.0, "ins_c": -1.0}, "id": "PUNP5", "gene_reaction_rule": "TM1737 or TM1596"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Pyruvate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYK"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "h_c": -1.0, "atp_c": 1.0, "adp_c": -1.0}, "id": "PYK", "gene_reaction_rule": "TM0208"}, {"subsystem": "Pyrimidine Metabolism", "name": "Pyrimidine-nucleoside phosphorylase (cytosine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYNP1"]}, "metabolites": {"cytd_c": 1.0, "pi_c": 1.0, "csn_c": -1.0, "r1p_c": -1.0}, "id": "PYNP1", "gene_reaction_rule": "TM1653"}, {"subsystem": "NAD Metabolism", "name": "Quinolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["QULNS"]}, "metabolites": {"h2o_c": 2.0, "pi_c": 1.0, "quln_c": 1.0, "dhap_c": -1.0, "iasp_c": -1.0}, "id": "QULNS", "gene_reaction_rule": "TM1644"}, {"subsystem": "Transport", "name": "Raffinose transport via ABC system (import)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RAFFabc"]}, "metabolites": {"raffin_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "raffin_e": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "RAFFabc", "gene_reaction_rule": "TM1204 and TM1203 and TM1202"}, {"subsystem": "Raffinose Metabolism", "name": "Raffinose hydrolyzing enzyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RAFH"]}, "metabolites": {"raffin_c": -1.0, "melib_c": 1.0, "h2o_c": -1.0, "fru_c": 1.0}, "id": "RAFH", "gene_reaction_rule": "TM1414"}, {"subsystem": "Riboflavin Metabolism", "name": "Riboflavin kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFK"]}, "metabolites": {"h_c": 1.0, "fmn_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "ribflv_c": -1.0}, "id": "RBFK", "gene_reaction_rule": ""}, {"subsystem": "Riboflavin Metabolism", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSa"]}, "metabolites": {"4r5au_c": -1.0, "h2o_c": 2.0, "dmlz_c": 1.0, "pi_c": 1.0, "db4p_c": -1.0}, "id": "RBFSa", "gene_reaction_rule": "TM1827 and TM1825"}, {"subsystem": "Riboflavin Metabolism", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSb"]}, "metabolites": {"4r5au_c": 1.0, "dmlz_c": -2.0, "ribflv_c": 1.0}, "id": "RBFSb", "gene_reaction_rule": "TM1827 and TM1825"}, {"subsystem": "Arabinose Metabolism", "name": "L-ribulokinase (L-ribulose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RBK_L1r"]}, "metabolites": {"rbl__L_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ru5p__L_c": 1.0}, "id": "RBK_L1", "gene_reaction_rule": "TM0284"}, {"subsystem": "Ribose Metabolism", "name": "Ribokinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RBKr"]}, "metabolites": {"h_c": 1.0, "r5p_c": 1.0, "rib__D_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "RBK", "gene_reaction_rule": "TM0960"}, {"subsystem": "Carbohydrate Metabolism", "name": "L-ribulose-phosphate 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RBP4E"]}, "metabolites": {"xu5p__D_c": 1.0, "ru5p__L_c": -1.0}, "id": "RBP4E", "gene_reaction_rule": "TM0283"}, {"subsystem": "Transport", "name": "D-ribose transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RIBabc"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "rib__D_e": -1.0, "rib__D_c": 1.0}, "id": "RIBabc", "gene_reaction_rule": "TM0956 and TM0958 and TM0955 and TM0959"}, {"subsystem": "Rhamnose Metabolism", "name": "L-rhamnose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMI"]}, "metabolites": {"rmn_c": -1.0, "rml_c": 1.0}, "id": "RMI", "gene_reaction_rule": "TM1071"}, {"subsystem": "Rhamnose Metabolism", "name": "Rhamnulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RMK"]}, "metabolites": {"adp_c": 1.0, "rml_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "rml1p_c": 1.0}, "id": "RMK", "gene_reaction_rule": "TM1073"}, {"subsystem": "Transport", "name": "L-rhamnose transport (ATP-dependent)", "upper_bound": 1000.0, 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synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "sertrna_c": 1.0, "ser__L_c": -1.0, "amp_c": 1.0, "trnaser_c": -1.0}, "id": "SERTRS", "gene_reaction_rule": "TM1379"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine deaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERD_Lr"]}, "metabolites": {"pyr_c": 1.0, "ser__L_c": -1.0, "nh4_c": 1.0}, "id": "SERD_L", "gene_reaction_rule": "TM0356"}, {"subsystem": "Chorismate Biosynthesis", "name": "Shikimate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SHK3Dr"]}, "metabolites": {"3dhsk_c": -1.0, "skm_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "SHK3Dr", "gene_reaction_rule": "TM0346"}, {"subsystem": "Chorismate Biosynthesis", "name": "Shikimate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHKK"]}, "metabolites": {"skm5p_c": 1.0, "skm_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "SHKK", "gene_reaction_rule": "TM0348"}, {"subsystem": "Methionine Metabolism", "name": "O-succinylhomoserine lyase (L-cysteine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHSL1"]}, "metabolites": {"cys__L_c": -1.0, "succ_c": 1.0, "suchms_c": -1.0, "h_c": 1.0, "cyst__L_c": 1.0}, "id": "SHSL1", "gene_reaction_rule": "TM1270 or TM0882"}, {"subsystem": "Methionine Metabolism", "name": "SHSL2r", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SHSL2r"]}, "metabolites": {"hcys__L_c": 1.0, "succ_c": 1.0, "suchms_c": -1.0, "h_c": 1.0, "h2s_c": -1.0}, "id": "SHSL2r", "gene_reaction_rule": "TM1270"}, {"subsystem": "Methionine Metabolism", "name": "O succinylhomoserine lyase  elimination   reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SHSL4r"]}, "metabolites": {"h2o_c": -1.0, 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-1.0, "h_c": 1.0, "5mta_c": 1.0}, "id": "SPRMS", "gene_reaction_rule": ""}, {"subsystem": "Glycine and Serine Metabolism", "name": "Serine-pyruvate aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SPTc"]}, "metabolites": {"hpyr_c": 1.0, "ser__L_c": -1.0, "ala__L_c": 1.0, "pyr_c": -1.0}, "id": "SPTc", "gene_reaction_rule": "TM1400"}, {"subsystem": "Citric Acid Cycle", "name": "Succinate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SUCD1"]}, "metabolites": {"succ_c": -1.0, "fum_c": 1.0, "fadh2_c": 1.0, "fad_c": -1.0}, "id": "SUCD1", "gene_reaction_rule": "TM0427 or TM0428"}, {"subsystem": "Energy Metabolism", "name": "Succinate dehydrogenase cytochrome b", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SUCD3"]}, "metabolites": {"q_c": -1.0, "fadh2_c": -1.0, "qh2_c": 1.0, "fad_c": 1.0}, "id": "SUCD3", "gene_reaction_rule": "TM0427 or TM0428"}, {"subsystem": 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dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SULFDH"]}, "metabolites": {"s_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "h2s_c": 1.0}, "id": "SULFDH", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "St", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["St"]}, "metabolites": {"s_c": 1.0, "s_e": -1.0}, "id": "St", "gene_reaction_rule": "S_0001"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transaldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TALA"]}, "metabolites": {"e4p_c": 1.0, "f6p_c": 1.0, "s7p_c": -1.0, "g3p_c": -1.0}, "id": "TALA", "gene_reaction_rule": "TM0295"}, {"subsystem": "Lysine Biosynthesis", "name": "L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THPAT"]}, "metabolites": {"nal2a6o_c": 1.0, "thdp_c": -1.0, "h2o_c": -1.0, "coa_c": 1.0, 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRS"]}, "metabolites": {"phom_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "thr__L_c": 1.0}, "id": "THRS", "gene_reaction_rule": "TM0546"}, {"subsystem": "Threonine Metabolism", "name": "Threonyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRTRS"]}, "metabolites": {"atp_c": -1.0, "thrtrna_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0, "thr__L_c": -1.0, "trnathr_c": -1.0}, "id": "THRTRS", "gene_reaction_rule": "TM0740"}, {"subsystem": "Transport", "name": "L threonine transport via ABC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "thr__L_c": 1.0, "pi_c": 1.0, "thr__L_e": -1.0}, "id": "THRabc", "gene_reaction_rule": "TM1139 and TM1138 and TM1136 and TM1135 and TM1137"}, {"subsystem": "Thiamine Biosynthesis", "name": "Thiazole phosphate synthesis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THZPSN"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": 1.0, "atp_c": -1.0, "4mpetz_c": 1.0, "ppi_c": 1.0, "ala__L_c": 1.0, "4hba_c": 1.0, "dxyl5p_c": -1.0, "h_c": 1.0, "tyr__L_c": -1.0, "co2_c": 1.0, "amp_c": 1.0}, "id": "THZPSN", "gene_reaction_rule": "TM1267"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transketolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT1"]}, "metabolites": {"r5p_c": -1.0, "xu5p__D_c": -1.0, "g3p_c": 1.0, "s7p_c": 1.0}, "id": "TKT1", "gene_reaction_rule": "TM1762 or (TM0953 and TM0954)"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transketolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT2"]}, "metabolites": {"e4p_c": -1.0, "xu5p__D_c": -1.0, "g3p_c": 1.0, "f6p_c": 1.0}, "id": "TKT2", "gene_reaction_rule": "TM1762 or (TM0953 and TM0954)"}, {"subsystem": "Pyrimidine Metabolism", "name": "Thymidine kinase (ATP:thymidine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDK1"]}, "metabolites": {"thymd_c": -1.0, "dtmp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "TMDK1", "gene_reaction_rule": "TM0401"}, {"subsystem": "Pyrimidine Metabolism", "name": "Thymidine phosphorylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMDPP"]}, "metabolites": {"2dr1p_c": 1.0, "pi_c": -1.0, "thym_c": 1.0, "thymd_c": -1.0}, "id": "TMDPP", "gene_reaction_rule": "TM1653"}, {"subsystem": "Pyrimidine Metabolism", "name": "Thymidylate synthase (FAD dependent)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDS3"]}, "metabolites": {"dtmp_c": 1.0, "nadph_c": -1.0, "mlthf_c": -1.0, "dump_c": -1.0, "nadp_c": 1.0, "thf_c": 1.0, "h_c": -1.0}, "id": "TMDS3", "gene_reaction_rule": "TM0449"}, {"subsystem": "Thiamine Biosynthesis", "name": "Thiamine-phosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, 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{"original_bigg_ids": ["TM_GL2"]}, "metabolites": {"glyc_c": -1.0, "ACP_c": 2.0, "udp_c": 2.0, "TM_GL2_c": 1.0, "h_c": 2.0, "palmACP_c": -2.0, "udpg_c": -2.0}, "id": "TM_GL2", "gene_reaction_rule": ""}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Triose-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TPI"]}, "metabolites": {"dhap_c": -1.0, "g3p_c": 1.0}, "id": "TPI", "gene_reaction_rule": "TM0689"}, {"subsystem": "Energy Metabolism", "name": "Thioredoxin reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRDR"]}, "metabolites": {"trdox_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "trdrd_c": 1.0}, "id": "TRDR", "gene_reaction_rule": "TM0134 or TM0869"}, {"subsystem": "Trehalose Metabolism", "name": "Alpha,alpha-trehalase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREH"]}, "metabolites": {"glc__D_c": 2.0, "tre_c": -1.0, "h2o_c": -1.0}, "id": "TREH", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "TREabc", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREabc"]}, "metabolites": {"h2o_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "tre_c": 1.0, "h_c": 1.0, "tre_e": -1.0, "pi_c": 1.0}, "id": "TREabc", "gene_reaction_rule": "TM1839 and TM_1837 and TM1836"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPS1r"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "g3p_c": 1.0, "trp__L_c": 1.0, "3ig3p_c": -1.0}, "id": "TRPS1", "gene_reaction_rule": "TM0137 and TM0138 and TM0539"}, {"subsystem": "Phenylalanine Tyrosine Tryptophan Biosynthesis", "name": "Tryptophan synthase (indole)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS2"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "indole_c": -1.0, 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"TYRTA", "gene_reaction_rule": "TM1040 or (TM1698 or TM1255)"}, {"subsystem": "tRNA Metabolism", "name": "Tyrosyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "tyrtrna_c": 1.0, "trnatyr_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTRS", "gene_reaction_rule": "TM0478"}, {"subsystem": "Peptidoglycan Biosynthesis", "name": "UAAGLS2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAAGLS2"]}, "metabolites": {"lys__L_c": -1.0, "atp_c": -1.0, "uGgl_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uamag_c": -1.0}, "id": "UAAGLS2", "gene_reaction_rule": "TM0237"}, {"subsystem": "Peptidoglycan Biosynthesis", "name": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UAGCVT_r"]}, "metabolites": {"pep_c": -1.0, "uacgam_c": -1.0, "uaccg_c": 1.0, "pi_c": 1.0}, "id": "UAGCVT", 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{"subsystem": "Lipid Biosynthesis", "name": "Undecaprenyl diphosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDPS"]}, "metabolites": {"udcpdp_c": 1.0, "ppi_c": 8.0, "ipdp_c": -8.0, "frdp_c": -1.0}, "id": "UDCPDPS", "gene_reaction_rule": "TM1398"}, {"subsystem": "Galactose metabolism", "name": "UDPglucose 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPG4E"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0}, "id": "UDPG4E", "gene_reaction_rule": "TM0509"}, {"subsystem": "Galactose metabolism", "name": "UDPglucose 6-dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGD"]}, "metabolites": {"h2o_c": -1.0, "udpglcur_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0, "udpg_c": -1.0}, "id": "UDPGD", "gene_reaction_rule": "TM0583"}, {"subsystem": "Peptidoglycan Biosynthesis", "name": "UGLDDS2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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{"notes": {"original_bigg_ids": ["TM_0356"]}, "name": "None", "id": "TM0356"}, {"notes": {"original_bigg_ids": ["TM_0346"]}, "name": "None", "id": "TM0346"}, {"notes": {"original_bigg_ids": ["TM_0654"]}, "name": "None", "id": "TM0654"}, {"notes": {"original_bigg_ids": ["TM_0427"]}, "name": "None", "id": "TM0427"}, {"notes": {"original_bigg_ids": ["TM_0752"]}, "name": "None", "id": "TM0752"}, {"notes": {"original_bigg_ids": ["TM_1068"]}, "name": "None", "id": "TM1068"}, {"notes": {"original_bigg_ids": ["TM_0295"]}, "name": "None", "id": "TM0295"}, {"notes": {"original_bigg_ids": ["TM_1519"]}, "name": "None", "id": "TM1519"}, {"notes": {"original_bigg_ids": ["TM_1744"]}, "name": "None", "id": "TM1744"}, {"notes": {"original_bigg_ids": ["TM_0546"]}, "name": "None", "id": "TM0546"}, {"notes": {"original_bigg_ids": ["TM_0740"]}, "name": "thrS", "id": "TM0740"}, {"notes": {"original_bigg_ids": ["TM_1267"]}, "name": "thiH", "id": "TM1267"}, {"notes": {"original_bigg_ids": ["TM_0953"]}, "name": "None", "id": "TM0953"}, {"notes": {"original_bigg_ids": ["TM_0954"]}, "name": "None", "id": "TM0954"}, {"notes": {"original_bigg_ids": ["TM_1762"]}, "name": "None", "id": "TM1762"}, {"notes": {"original_bigg_ids": ["TM_0449"]}, "name": "thyX", "id": "TM0449"}, {"notes": {"original_bigg_ids": ["TM_0869"]}, "name": "None", "id": "TM0869"}, {"notes": {"original_bigg_ids": ["TM_0134"]}, "name": "None", "id": "TM0134"}, {"notes": {"original_bigg_ids": ["TM_0138"]}, "name": "None", "id": "TM0138"}, {"notes": {"original_bigg_ids": ["TM_0137"]}, "name": "trpA", "id": "TM0137"}, {"notes": {"original_bigg_ids": ["TM_0539"]}, "name": "None", "id": "TM0539"}, {"notes": {"original_bigg_ids": ["TM_0492"]}, "name": "None", "id": "TM0492"}, {"notes": {"original_bigg_ids": ["TM_0478"]}, "name": "None", "id": "TM0478"}, {"notes": {"original_bigg_ids": ["TM_0237"]}, "name": "None", "id": "TM0237"}, {"notes": {"original_bigg_ids": ["TM_0108"]}, "name": "None", "id": "TM0108"}, {"notes": {"original_bigg_ids": ["TM_0232"]}, "name": "None", "id": "TM0232"}, {"notes": {"original_bigg_ids": ["TM_0234"]}, "name": "None", "id": "TM0234"}, {"notes": {"original_bigg_ids": ["TM_0231"]}, "name": "None", "id": "TM0231"}, {"notes": {"original_bigg_ids": ["TM_1714"]}, "name": "murB", "id": "TM1714"}, {"notes": {"original_bigg_ids": ["TM_1398"]}, "name": "None", "id": "TM1398"}, {"notes": {"original_bigg_ids": ["TM_0509"]}, "name": "None", "id": "TM0509"}, {"notes": {"original_bigg_ids": ["TM_0583"]}, "name": "None", "id": "TM0583"}, {"notes": {"original_bigg_ids": ["TM_0236"]}, "name": "None", "id": "TM0236"}, {"notes": {"original_bigg_ids": ["TM_0721"]}, "name": "upp", "id": "TM0721"}, {"notes": {"original_bigg_ids": ["TM_0819"]}, "name": "None", "id": "TM0819"}, {"notes": {"original_bigg_ids": ["TM_1817"]}, "name": "None", "id": "TM1817"}, {"notes": {"original_bigg_ids": ["TM_0061"]}, "name": "None", "id": "TM0061"}, {"notes": {"original_bigg_ids": ["TM_0070"]}, "name": "None", "id": "TM0070"}, {"notes": {"original_bigg_ids": ["TM_0075"]}, "name": "None", "id": "TM0075"}, {"notes": {"original_bigg_ids": ["TM_0071"]}, "name": "None", "id": "TM0071"}, {"notes": {"original_bigg_ids": ["TM_0074"]}, "name": "None", "id": "TM0074"}, {"notes": {"original_bigg_ids": ["TM_0073"]}, "name": "None", "id": "TM0073"}, {"notes": {"original_bigg_ids": ["TM_0072"]}, "name": "None", "id": "TM0072"}, {"notes": {"original_bigg_ids": ["TM_0060"]}, "name": "None", "id": "TM0060"}, {"notes": {"original_bigg_ids": ["TM_0057"]}, "name": "None", "id": "TM0057"}, {"notes": {"original_bigg_ids": ["TM_0059"]}, "name": "None", "id": "TM0059"}, {"notes": {"original_bigg_ids": ["TM_0058"]}, "name": "None", "id": "TM0058"}, {"notes": {"original_bigg_ids": ["TM_0056"]}, "name": "None", "id": "TM0056"}, {"notes": {"original_bigg_ids": ["TM_1667"]}, "name": "None", "id": "TM1667"}, {"notes": {"original_bigg_ids": ["TM_0116"]}, "name": "None", "id": "TM0116"}, {"notes": {"original_bigg_ids": ["TM_0112"]}, "name": "None", "id": "TM0112"}, {"notes": {"original_bigg_ids": ["TM_0115"]}, "name": "None", "id": "TM0115"}, {"notes": {"original_bigg_ids": ["TM_0114"]}, "name": "None", "id": "TM0114"}, {"notes": {"original_bigg_ids": ["TM_0124"]}, "name": "None", "id": "TM0124"}, {"notes": {"original_bigg_ids": ["TM_0123"]}, "name": "None", "id": "TM0123"}, {"notes": {"original_bigg_ids": ["TM_0125"]}, "name": "None", "id": "TM0125"}, {"notes": {"original_bigg_ids": ["TM1015"]}, "name": "None", "id": "TM1015"}], "compartments": {"c": "cytosol", "e": "extracellular space"}, "metabolites": [{"formula": "C20H21N7O7", "notes": {"original_bigg_ids": ["10fthf[c]"]}, "compartment": "c", "name": "10-Formyltetrahydrofolate", "id": "10fthf_c"}, {"formula": "C3H4O10P2", "notes": {"original_bigg_ids": ["13dpg[c]"]}, "compartment": "c", "name": "3-Phospho-D-glyceroyl phosphate", "id": "13dpg_c"}, {"formula": "C19H37O7P1", "notes": {"original_bigg_ids": ["1hdecg3p[c]"]}, "compartment": "c", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate", "id": "1hdecg3p_c"}, {"formula": "C5H6NO3", "notes": {"original_bigg_ids": ["1p3h5c[c]"]}, "compartment": "c", "name": "L 1 Pyrroline 3 hydroxy 5 carboxylate C5H6NO3", "id": "1p3h5c_c"}, {"formula": "C5H6NO2", "notes": {"original_bigg_ids": ["1pyr5c[c]"]}, "compartment": "c", "name": "1-Pyrroline-5-carboxylate", "id": "1pyr5c_c"}, {"formula": "C7H5NO4", "notes": {"original_bigg_ids": ["23dhdp[c]"]}, "compartment": "c", "name": "2,3-Dihydrodipicolinate", "id": "23dhdp_c"}, {"formula": "C5H9O4", "notes": {"original_bigg_ids": ["23dhmb[c]"]}, "compartment": "c", "name": "(R)-2,3-Dihydroxy-3-methylbutanoate", "id": "23dhmb_c"}, {"formula": "C6H11O4", "notes": {"original_bigg_ids": ["23dhmp[c]"]}, "compartment": "c", "name": "(R)-2,3-Dihydroxy-3-methylpentanoate", "id": "23dhmp_c"}, {"formula": "C13H15N4O12P", "notes": {"original_bigg_ids": ["25aics[c]"]}, "compartment": "c", "name": 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{"original_bigg_ids": ["2ahhmp[c]"]}, "compartment": "c", "name": "2 Amino 4 hydroxy 6 hydroxymethyl 7 8 dihydropteridine C7H9N5O2", "id": "2ahhmp_c"}, {"formula": "C12H13NO9P", "notes": {"original_bigg_ids": ["2cpr5p[c]"]}, "compartment": "c", "name": "1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "id": "2cpr5p_c"}, {"formula": "C7H10O10P", "notes": {"original_bigg_ids": ["2dda7p[c]"]}, "compartment": "c", "name": "2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate", "id": "2dda7p_c"}, {"formula": "C6H8O9P", "notes": {"original_bigg_ids": ["2ddg6p[c]"]}, "compartment": "c", "name": "2-Dehydro-3-deoxy-D-gluconate 6-phosphate", "id": "2ddg6p_c"}, {"formula": "C6H9O6", "notes": {"original_bigg_ids": ["2ddglcn[c]"]}, "compartment": "c", "name": "2-Dehydro-3-deoxy-D-gluconate", "id": "2ddglcn_c"}, {"formula": "C6H9O4", "notes": {"original_bigg_ids": ["2dhp[c]"]}, "compartment": "c", "name": "2-Dehydropantoate", "id": "2dhp_c"}, {"formula": "C5H9O7P", "notes": {"original_bigg_ids": ["2dr1p[c]"]}, "compartment": "c", "name": "2-Deoxy-D-ribose 1-phosphate", "id": "2dr1p_c"}, {"formula": "C5H9O7P", "notes": {"original_bigg_ids": ["2dr5p[c]"]}, "compartment": "c", "name": "2-Deoxy-D-ribose 5-phosphate", "id": "2dr5p_c"}, {"formula": "C7H8O4", "notes": {"original_bigg_ids": ["2ippm[c]"]}, "compartment": "c", "name": "2-Isopropylmaleate", "id": "2ippm_c"}, {"formula": "C6H8N3O7P2", "notes": {"original_bigg_ids": ["2mahmp[c]"]}, "compartment": "c", "name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "id": "2mahmp_c"}, {"formula": "C5H11O7P", "notes": {"original_bigg_ids": ["2me4p[c]"]}, "compartment": "c", "name": "2-C-methyl-D-erythritol 4-phosphate", "id": "2me4p_c"}, {"formula": "C5H10O9P2", "notes": {"original_bigg_ids": ["2mecdp[c]"]}, "compartment": "c", "name": "2-C-methyl-D-erythritol 2,4-cyclodiphosphate", "id": "2mecdp_c"}, {"formula": "C4H5O3", "notes": {"original_bigg_ids": ["2obut[c]"]}, "compartment": "c", "name": 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"notes": {"original_bigg_ids": ["3dhq[c]"]}, "compartment": "c", "name": "3-Dehydroquinate", "id": "3dhq_c"}, {"formula": "C7H7O5", "notes": {"original_bigg_ids": ["3dhsk[c]"]}, "compartment": "c", "name": "3-Dehydroshikimate", "id": "3dhsk_c"}, {"formula": "C29H55N2O9PRS", "notes": {"original_bigg_ids": ["3hoctaACP[c]"]}, "compartment": "c", "name": "(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "id": "3hoctaACP_c"}, {"formula": "C27H51N2O9PRS", "notes": {"original_bigg_ids": ["3hpalmACP[c]"]}, "compartment": "c", "name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "id": "3hpalmACP_c"}, {"formula": "C11H12NO6P", "notes": {"original_bigg_ids": ["3ig3p[c]"]}, "compartment": "c", "name": "C'-(3-Indolyl)-glycerol 3-phosphate", "id": "3ig3p_c"}, {"formula": "C5H7O3", "notes": {"original_bigg_ids": ["3mob[c]"]}, "compartment": "c", "name": "3-Methyl-2-oxobutanoate", "id": "3mob_c"}, {"formula": "C6H9O3", "notes": {"original_bigg_ids": ["3mop[c]"]}, "compartment": "c", "name": 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"4abz_c"}, {"formula": "C10H10NO5", "notes": {"original_bigg_ids": ["4adcho[c]"]}, "compartment": "c", "name": "4-amino-4-deoxychorismate", "id": "4adcho_c"}, {"formula": "C6H9N3O", "notes": {"original_bigg_ids": ["4ahmmp[c]"]}, "compartment": "c", "name": "4-Amino-5-hydroxymethyl-2-methylpyrimidine", "id": "4ahmmp_c"}, {"formula": "C6H8N3O4P", "notes": {"original_bigg_ids": ["4ampm[c]"]}, "compartment": "c", "name": "4-Amino-2-methyl-5-phosphomethylpyrimidine", "id": "4ampm_c"}, {"formula": "C14H23N3O14P2", "notes": {"original_bigg_ids": ["4c2me[c]"]}, "compartment": "c", "name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol", "id": "4c2me_c"}, {"formula": "C5H4O6", "notes": {"original_bigg_ids": ["4h2oglt[c]"]}, "compartment": "c", "name": "4 Hydroxy 2 oxoglutarate C5H4O6", "id": "4h2oglt_c"}, {"formula": "C7H8O2", "notes": {"original_bigg_ids": ["4hba[c]"]}, "compartment": "c", "name": "4-Hydroxy-benzyl alcohol", "id": "4hba_c"}, {"formula": "C5H9NO3", "notes": {"original_bigg_ids": ["4hpro_LT[c]"]}, "compartment": "c", "name": "Trans 4 Hydroxy L proline C5H9NO3", "id": "4hpro_LT_c"}, {"formula": "C6H9O3", "notes": {"original_bigg_ids": ["4mop[c]"]}, "compartment": "c", "name": "4-Methyl-2-oxopentanoate", "id": "4mop_c"}, {"formula": "C6H8NO4PS", "notes": {"original_bigg_ids": ["4mpetz[c]"]}, "compartment": "c", "name": "4-Methyl-5-(2-phosphoethyl)-thiazole", "id": "4mpetz_c"}, {"formula": "C4H6NO7P", "notes": {"original_bigg_ids": ["4pasp[c]"]}, "compartment": "c", "name": "4-Phospho-L-aspartate", "id": "4pasp_c"}, {"formula": "C9H15NO8P", "notes": {"original_bigg_ids": ["4ppan[c]"]}, "compartment": "c", "name": "D-4'-Phosphopantothenate", "id": "4ppan_c"}, {"formula": "C12H20N2O9PS", "notes": {"original_bigg_ids": ["4ppcys[c]"]}, "compartment": "c", "name": "N-((R)-4-Phosphopantothenoyl)-L-cysteine", "id": "4ppcys_c"}, {"formula": "C9H16N4O6", "notes": {"original_bigg_ids": ["4r5au[c]"]}, "compartment": "c", "name": "4-(1-D-Ribitylamino)-5-aminouracil", "id": "4r5au_c"}, {"formula": "C9H11N3O9P", "notes": {"original_bigg_ids": ["5aizc[c]"]}, "compartment": "c", "name": "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate", "id": "5aizc_c"}, {"formula": "C9H15N4O9P", "notes": {"original_bigg_ids": ["5aprbu[c]"]}, "compartment": "c", "name": "5-Amino-6-(5'-phosphoribitylamino)uracil", "id": "5aprbu_c"}, {"formula": "C9H13N4O9P", "notes": {"original_bigg_ids": ["5apru[c]"]}, "compartment": "c", "name": "5-Amino-6-(5'-phosphoribosylamino)uracil", "id": "5apru_c"}, {"formula": "C20H22N8O6", "notes": {"original_bigg_ids": ["5forthf[c]"]}, "compartment": "c", "name": "5forthf c", "id": "5forthf_c"}, {"formula": "C20H21N7O7", "notes": {"original_bigg_ids": ["5fthf[c]"]}, "compartment": "c", "name": "5-Formyltetrahydrofolate", "id": "5fthf_c"}, {"formula": "C6H11O7PS", "notes": {"original_bigg_ids": ["5mdr1p[c]"]}, "compartment": "c", "name": "5-Methylthio-5-deoxy-D-ribose 1-phosphate", "id": "5mdr1p_c"}, {"formula": "C6H11O7PS", "notes": {"original_bigg_ids": ["5mdru1p[c]"]}, "compartment": "c", "name": "5-Methylthio-5-deoxy-D-ribulose 1-phosphate", "id": "5mdru1p_c"}, {"formula": "C11H15N5O3S", "notes": {"original_bigg_ids": ["5mta[c]"]}, "compartment": "c", "name": "5-Methylthioadenosine", "id": "5mta_c"}, {"formula": "C20H24N7O6", "notes": {"original_bigg_ids": ["5mthf[c]"]}, "compartment": "c", "name": "5-Methyltetrahydrofolate", "id": "5mthf_c"}, {"formula": "C25H34N8O12", "notes": {"original_bigg_ids": ["5mthglu[c]"]}, "compartment": "c", "name": "5-Methyltetrahydropteroyltri-L-glutamate", "id": "5mthglu_c"}, {"formula": "C6H12O4S", "notes": {"original_bigg_ids": ["5mtr[c]"]}, "compartment": "c", "name": "5-Methylthio-D-ribose", "id": "5mtr_c"}, {"formula": "C6H10O10P", "notes": {"original_bigg_ids": ["6pgc[c]"]}, "compartment": "c", "name": "6-Phospho-D-gluconate", "id": "6pgc_c"}, {"formula": "C12H21O14P", "notes": {"original_bigg_ids": ["6pgg[c]"]}, "compartment": "c", "name": "6pgg c", "id": "6pgg_c"}, {"formula": "C6H9O9P", "notes": {"original_bigg_ids": ["6pgl[c]"]}, "compartment": "c", "name": "6-phospho-D-glucono-1,5-lactone", "id": "6pgl_c"}, {"formula": "C9H11N5O3", "notes": {"original_bigg_ids": ["6pthp[c]"]}, "compartment": "c", "name": "6-Pyruvoyl-5,6,7,8-tetrahydropterin", "id": "6pthp_c"}, {"formula": "C11H21N2O7PRS", "notes": {"original_bigg_ids": ["ACP[c]"]}, "compartment": "c", "name": "Acyl carrier protein", "id": "ACP_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["Glc_aD[c]"]}, "compartment": "c", "name": "Alpha D-glucose", "id": "Glc_aD_c"}, {"formula": "C10H13NO5", "notes": {"original_bigg_ids": ["Largn[c]"]}, "compartment": "c", "name": "L-Arogenate", "id": "Largn_c"}, {"formula": "C3H6NO5S", "notes": {"original_bigg_ids": ["Lcyst[c]"]}, "compartment": "c", "name": "L-Cysteate", "id": "Lcyst_c"}, {"formula": "C6H9NO5", "notes": {"original_bigg_ids": ["Nforglu[c]"]}, "compartment": "c", "name": "N-Formyl-L-glutamate", "id": "Nforglu_c"}, {"formula": "C57H106O16", "notes": {"original_bigg_ids": ["TM_GL1[c]"]}, "compartment": "c", "name": "Thermotoga maritima glycolipid 1", "id": "TM_GL1_c"}, {"formula": "C47H88O15", "notes": {"original_bigg_ids": ["TM_GL2[c]"]}, "compartment": "c", "name": "Thermotoga maritima glycolipid 2", "id": "TM_GL2_c"}, {"formula": "C2H3O2", "notes": {"original_bigg_ids": ["ac[c]"]}, "compartment": "c", "name": "Acetate", "id": "ac_c"}, {"formula": "C13H23N2O8PRS", "notes": {"original_bigg_ids": ["acACP[c]"]}, "compartment": "c", "name": "Acetyl-ACP", "id": "acACP_c"}, {"formula": "C2H4O", "notes": {"original_bigg_ids": ["acald[c]"]}, "compartment": "c", "name": "Acetaldehyde", "id": "acald_c"}, {"formula": "C23H34N7O17P3S", "notes": {"original_bigg_ids": ["accoa[c]"]}, "compartment": "c", "name": "Acetyl-CoA", "id": "accoa_c"}, {"formula": "C3H6O2", "notes": {"original_bigg_ids": ["acetol[c]"]}, "compartment": "c", "name": "Acetol", "id": "acetol_c"}, {"formula": "C7H9NO8P", "notes": {"original_bigg_ids": ["acg5p[c]"]}, "compartment": "c", "name": "N-Acetyl-L-glutamyl 5-phosphate", "id": "acg5p_c"}, {"formula": "C7H10NO4", "notes": {"original_bigg_ids": ["acg5sa[c]"]}, "compartment": "c", "name": "N-Acetyl-L-glutamate 5-semialdehyde", "id": "acg5sa_c"}, {"formula": "C8H15NO6", "notes": {"original_bigg_ids": ["acgam[c]"]}, "compartment": "c", "name": "N-Acetyl-D-glucosamine", "id": "acgam_c"}, {"formula": "C8H14NO9P", "notes": {"original_bigg_ids": ["acgam1p[c]"]}, "compartment": "c", "name": "N-Acetyl-D-glucosamine 1-phosphate", "id": "acgam1p_c"}, {"formula": "C8H14NO9P", "notes": {"original_bigg_ids": ["acgam6p[c]"]}, "compartment": "c", "name": "N-Acetyl-D-glucosamine 6-phosphate", "id": "acgam6p_c"}, {"formula": "C7H9NO5", "notes": {"original_bigg_ids": ["acglu[c]"]}, "compartment": "c", "name": "N-Acetyl-L-glutamate", "id": "acglu_c"}, {"formula": "C6H11NO4", "notes": {"original_bigg_ids": ["achms[c]"]}, "compartment": "c", "name": "O Acetyl L homoserine C6H11NO4", "id": "achms_c"}, {"formula": "C7H14N2O3", "notes": {"original_bigg_ids": ["acorn[c]"]}, "compartment": "c", "name": "N2-Acetyl-L-ornithine", "id": "acorn_c"}, {"formula": "C5H9NO4", "notes": {"original_bigg_ids": ["acser[c]"]}, "compartment": "c", "name": "O-Acetyl-L-serine", "id": "acser_c"}, {"formula": "C15H25N2O9PRS", "notes": {"original_bigg_ids": ["actACP[c]"]}, "compartment": "c", "name": "Acetoacetyl-ACP", "id": "actACP_c"}, {"formula": "C2H3O5P", "notes": {"original_bigg_ids": ["actp[c]"]}, "compartment": "c", "name": "Acetyl phosphate", "id": "actp_c"}, {"formula": "C5H5N5", "notes": {"original_bigg_ids": ["ade[c]"]}, "compartment": "c", "name": "Adenine", "id": "ade_c"}, {"formula": "C10H13N5O4", "notes": {"original_bigg_ids": ["adn[c]"]}, "compartment": "c", "name": "Adenosine", "id": "adn_c"}, {"formula": "C10H12N5O10P2", "notes": {"original_bigg_ids": ["adp[c]"]}, "compartment": "c", "name": "ADP", "id": "adp_c"}, {"formula": "C16H23N5O15P2", "notes": {"original_bigg_ids": ["adpglc[c]"]}, "compartment": "c", "name": "ADPglucose", "id": "adpglc_c"}, {"formula": "C14H20N6O5S", "notes": {"original_bigg_ids": ["ahcys[c]"]}, "compartment": "c", "name": "S-Adenosyl-L-homocysteine", "id": "ahcys_c"}, {"formula": "C9H12N5O13P3", "notes": {"original_bigg_ids": ["ahdt[c]"]}, "compartment": "c", "name": "2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate", "id": "ahdt_c"}, {"formula": "C9H13N4O8P", "notes": {"original_bigg_ids": ["aicar[c]"]}, "compartment": "c", "name": "5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide", "id": "aicar_c"}, {"formula": "C8H12N3O7P", "notes": {"original_bigg_ids": ["air[c]"]}, "compartment": "c", "name": "5-amino-1-(5-phospho-D-ribosyl)imidazole", "id": "air_c"}, {"formula": "C5H4O5", "notes": {"original_bigg_ids": ["akg[c]"]}, "compartment": "c", "name": "2-Oxoglutarate", "id": "akg_c"}, {"formula": "C3H7NO2", "notes": {"original_bigg_ids": ["ala_B[c]"]}, "compartment": "c", "name": "Beta-Alanine", "id": "ala_B_c"}, {"formula": "C3H7NO2", "notes": {"original_bigg_ids": ["ala_D[c]"]}, "compartment": "c", "name": "D-Alanine", "id": "ala__D_c"}, {"formula": "C3H7NO2", "notes": {"original_bigg_ids": ["ala_L[c]"]}, "compartment": "c", "name": "L-Alanine", "id": "ala__L_c"}, {"formula": "C6H12N2O3", "notes": {"original_bigg_ids": ["alaala[c]"]}, "compartment": "c", "name": "D-Alanyl-D-alanine", "id": "alaala_c"}, {"formula": "C5H7O4", "notes": {"original_bigg_ids": ["alac_S[c]"]}, "compartment": "c", "name": "(S)-2-Acetolactate", "id": "alac__S_c"}, {"formula": "C3H6NOR", "notes": {"original_bigg_ids": ["alatrna[c]"]}, "compartment": "c", "name": "L-Alanyl-tRNA(Ala)", "id": "alatrna_c"}, {"formula": "C15H23N6O5S", "notes": {"original_bigg_ids": ["amet[c]"]}, "compartment": "c", "name": "S-Adenosyl-L-methionine", "id": "amet_c"}, {"formula": "C14H24N6O3S", "notes": {"original_bigg_ids": ["ametam[c]"]}, "compartment": "c", "name": "S-Adenosylmethioninamine", "id": "ametam_c"}, {"formula": "C10H12N5O7P", "notes": {"original_bigg_ids": ["amp[c]"]}, "compartment": "c", "name": "AMP", "id": "amp_c"}, {"formula": "C7H6NO2", "notes": {"original_bigg_ids": ["anth[c]"]}, "compartment": "c", "name": "Anthranilate", "id": "anth_c"}, {"formula": "RHO", "notes": {"original_bigg_ids": ["apoACP[c]"]}, "compartment": "c", "name": "Apoprotein [acyl carrier protein]", "id": "apoACP_c"}, {"formula": "C5H10O5", "notes": {"original_bigg_ids": ["arab_L[c]"]}, "compartment": "c", "name": "L-Arabinose", "id": "arab__L_c"}, {"formula": "C31H59N2O8PRS", "notes": {"original_bigg_ids": ["arachACP[c]"]}, "compartment": "c", "name": "Eicosanoyl-ACP (n-C20:0)", "id": "arachACP_c"}, {"formula": "C31H57N2O8PRS", "notes": {"original_bigg_ids": ["aracheACP[c]"]}, "compartment": "c", "name": "Cis-eicosa-11-enoyl-[acyl-carrier protein] (n-C20:1)", "id": "aracheACP_c"}, {"formula": "C6H15N4O2", "notes": {"original_bigg_ids": ["arg_L[c]"]}, "compartment": "c", "name": "L-Arginine", "id": "arg__L_c"}, {"formula": "C10H17N4O6", "notes": {"original_bigg_ids": ["argsuc[c]"]}, "compartment": "c", "name": "N(omega)-(L-Arginino)succinate", "id": "argsuc_c"}, {"formula": "C6H14N4OR", "notes": {"original_bigg_ids": ["argtrna[c]"]}, "compartment": "c", "name": "L-Arginyl-tRNA(Arg)", "id": "argtrna_c"}, {"formula": "C14H23N2O12PR2", "notes": {"original_bigg_ids": ["asntrna[c]"]}, "compartment": "c", "name": "L-Asparaginyl-tRNA(Asn)", "id": "asntrna_c"}, {"formula": "C4H6NO4", "notes": {"original_bigg_ids": ["asp_L[c]"]}, "compartment": "c", "name": "L-Aspartate", "id": "asp__L_c"}, {"formula": "C4H7NO3", "notes": {"original_bigg_ids": ["aspsa[c]"]}, "compartment": "c", "name": "L-Aspartate 4-semialdehyde", "id": "aspsa_c"}, {"formula": "C4H5NO3R", "notes": {"original_bigg_ids": ["asptrna[c]"]}, "compartment": "c", "name": "L-Aspartyl-tRNA(Asp)", "id": "asptrna_c"}, {"formula": "None", "notes": {"original_bigg_ids": ["asptrna_asn_[c]"]}, "compartment": "c", "name": "L-Aspartyl-tRNA(Asn)", "id": "asptrna_asn_c"}, {"formula": "C4H9NO3", "notes": {"original_bigg_ids": ["athr_L[c]"]}, "compartment": "c", "name": "L-Allo-threonine", "id": "athr__L_c"}, {"formula": "C10H12N5O13P3", "notes": {"original_bigg_ids": ["atp[c]"]}, "compartment": "c", "name": "ATP", "id": "atp_c"}, {"formula": "C33H63N2O8PRS", "notes": {"original_bigg_ids": ["behenACP[c]"]}, "compartment": "c", "name": "Docosanoyl-ACP (n-C22:0)", "id": "behenACP_c"}, {"formula": "C33H61N2O8PRS", "notes": {"original_bigg_ids": ["beheneACP[c]"]}, "compartment": "c", "name": "Dosa-11-enoyl-ACP (n-C20:1)", "id": "beheneACP_c"}, {"formula": "C20H27N7O9PS", "notes": {"original_bigg_ids": ["btamp[c]"]}, "compartment": "c", "name": "Biotinyl 5  AMP C20H27N7O9PS", "id": "btamp_c"}, {"formula": "C25H38N7O17P3S", "notes": {"original_bigg_ids": ["btcoa[c]"]}, "compartment": "c", "name": "Butanoyl-CoA", "id": "btcoa_c"}, {"formula": "C10H15N2O3S", "notes": {"original_bigg_ids": ["btn[c]"]}, "compartment": "c", "name": "Biotin", "id": "btn_c"}, {"formula": "C4H7O2", "notes": {"original_bigg_ids": ["but[c]"]}, "compartment": "c", "name": "Butyrate (n-C4:0)", "id": "but_c"}, {"formula": "C4H7O5P", "notes": {"original_bigg_ids": ["butpi[c]"]}, "compartment": "c", "name": "Butanoyl phosphate", "id": "butpi_c"}, {"formula": "C5H6N2O5", "notes": {"original_bigg_ids": ["cbasp[c]"]}, "compartment": "c", "name": "N-Carbamoyl-L-aspartate", "id": "cbasp_c"}, {"formula": "CH2NO5P", "notes": {"original_bigg_ids": ["cbp[c]"]}, "compartment": "c", "name": "Carbamoyl phosphate", "id": "cbp_c"}, {"formula": "C9H12N3O11P2", "notes": {"original_bigg_ids": ["cdp[c]"]}, "compartment": "c", "name": "CDP", "id": "cdp_c"}, {"formula": "C15H23O16N3P2", "notes": {"original_bigg_ids": ["cdp_inost[c]"]}, "compartment": "c", "name": "CDP-Inositol", "id": "cdp_inost_c"}, {"formula": "C44H79N3O15P2", "notes": {"original_bigg_ids": ["cdpdhdecg[c]"]}, "compartment": "c", "name": "CDP-1,2-dihexadecanoylglycerol", "id": "cdpdhdecg_c"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["cell4[c]"]}, "compartment": "c", "name": "Cellulose (n=4 repeating units)", "id": "cell4_c"}, {"formula": "C36H62O31", "notes": {"original_bigg_ids": ["cell6[c]"]}, "compartment": "c", "name": "Cellulose (n=6 repeating units)", "id": "cell6_c"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["cellb[c]"]}, "compartment": "c", "name": "Cellobiose", "id": "cellb_c"}, {"formula": "C5H14NO", "notes": {"original_bigg_ids": ["chol[c]"]}, "compartment": "c", "name": "Choline", "id": "chol_c"}, {"formula": "C10H8O6", "notes": {"original_bigg_ids": ["chor[c]"]}, "compartment": "c", "name": "Chorismate", "id": "chor_c"}, {"formula": "C16H28N2O11", "notes": {"original_bigg_ids": ["chtbs[c]"]}, "compartment": "c", "name": "N,N'-diacetylchitobiose", "id": "chtbs_c"}, {"formula": "C6H5O7", "notes": {"original_bigg_ids": ["cit[c]"]}, "compartment": "c", "name": "Citrate", "id": "cit_c"}, {"formula": "C6H13N3O3", "notes": {"original_bigg_ids": ["citr_L[c]"]}, "compartment": "c", "name": "L-Citrulline", "id": "citr__L_c"}, {"formula": "C9H12N3O8P", "notes": {"original_bigg_ids": ["cmp[c]"]}, "compartment": "c", "name": "CMP", "id": "cmp_c"}, {"formula": "CO2", "notes": {"original_bigg_ids": ["co2[c]"]}, "compartment": "c", "name": "CO2", "id": "co2_c"}, {"formula": "C21H32N7O16P3S", "notes": {"original_bigg_ids": ["coa[c]"]}, "compartment": "c", "name": "Coenzyme A", "id": "coa_c"}, {"formula": "C4H9N3O2", "notes": {"original_bigg_ids": ["creat[c]"]}, "compartment": "c", "name": "Creat c", "id": "creat_c"}, {"formula": "C4H7N3O", "notes": {"original_bigg_ids": ["crtn[c]"]}, "compartment": "c", "name": "Crtn c", "id": "crtn_c"}, {"formula": "C4H5N3O", "notes": {"original_bigg_ids": ["csn[c]"]}, "compartment": "c", "name": "Cytosine", "id": "csn_c"}, {"formula": "C9H12N3O14P3", "notes": {"original_bigg_ids": ["ctp[c]"]}, "compartment": "c", "name": "CTP", "id": "ctp_c"}, {"formula": "C3H7NO2S", "notes": {"original_bigg_ids": ["cys_L[c]"]}, "compartment": "c", "name": "L-Cysteine", "id": "cys__L_c"}, {"formula": "C7H14N2O4S", "notes": {"original_bigg_ids": ["cyst_L[c]"]}, "compartment": "c", "name": "L-Cystathionine", "id": "cyst__L_c"}, {"formula": "C3H6NOSR", "notes": {"original_bigg_ids": ["cystrna[c]"]}, "compartment": "c", "name": "L-Cysteinyl-tRNA(Cys)", "id": "cystrna_c"}, {"formula": "C9H13N3O5", "notes": {"original_bigg_ids": ["cytd[c]"]}, "compartment": "c", "name": "Cytidine", "id": "cytd_c"}, {"formula": "C10H13N5O3", "notes": {"original_bigg_ids": ["dad_2[c]"]}, "compartment": "c", "name": "Deoxyadenosine", "id": "dad_2_c"}, {"formula": "C10H12N5O9P2", "notes": {"original_bigg_ids": ["dadp[c]"]}, "compartment": "c", "name": "DADP", "id": "dadp_c"}, {"formula": "C10H12N5O6P", "notes": {"original_bigg_ids": ["damp[c]"]}, "compartment": "c", "name": "DAMP", "id": "damp_c"}, {"formula": "C10H12N5O12P3", "notes": {"original_bigg_ids": ["datp[c]"]}, "compartment": "c", "name": "DATP", "id": "datp_c"}, {"formula": "C4H7O6P", "notes": {"original_bigg_ids": ["db4p[c]"]}, "compartment": "c", "name": "3,4-dihydroxy-2-butanone 4-phosphate", "id": "db4p_c"}, {"formula": "C21H39N2O8PRS", "notes": {"original_bigg_ids": ["dcaACP[c]"]}, "compartment": "c", "name": "Decanoyl-ACP (n-C10:0ACP)", "id": "dcaACP_c"}, {"formula": "C14H14N5O11P", "notes": {"original_bigg_ids": ["dcamp[c]"]}, "compartment": "c", "name": "N6-(1,2-Dicarboxyethyl)-AMP", "id": "dcamp_c"}, {"formula": "C9H12N3O10P2", "notes": {"original_bigg_ids": ["dcdp[c]"]}, "compartment": "c", "name": "DCDP", "id": "dcdp_c"}, {"formula": "C9H12N3O7P", "notes": {"original_bigg_ids": ["dcmp[c]"]}, "compartment": "c", "name": "DCMP", "id": "dcmp_c"}, {"formula": "C9H12N3O13P3", "notes": {"original_bigg_ids": ["dctp[c]"]}, "compartment": "c", "name": "DCTP", "id": "dctp_c"}, {"formula": "C9H13N3O4", "notes": {"original_bigg_ids": ["dcyt[c]"]}, "compartment": "c", "name": "Deoxycytidine", "id": "dcyt_c"}, {"formula": "C23H43N2O8PRS", "notes": {"original_bigg_ids": ["ddcaACP[c]"]}, "compartment": "c", "name": "Dodecanoyl-ACP (n-C12:0ACP)", "id": "ddcaACP_c"}, {"formula": "C10H12N5O10P2", "notes": {"original_bigg_ids": ["dgdp[c]"]}, "compartment": "c", "name": "DGDP", "id": "dgdp_c"}, {"formula": "C10H12N5O7P", "notes": {"original_bigg_ids": ["dgmp[c]"]}, "compartment": "c", "name": "DGMP", "id": "dgmp_c"}, {"formula": "C10H13N5O4", "notes": {"original_bigg_ids": ["dgsn[c]"]}, "compartment": "c", "name": "Deoxyguanosine", "id": "dgsn_c"}, {"formula": "C10H12N5O13P3", "notes": {"original_bigg_ids": ["dgtp[c]"]}, "compartment": "c", "name": "DGTP", "id": "dgtp_c"}, {"formula": "C3H6O3", "notes": {"original_bigg_ids": ["dha[c]"]}, "compartment": "c", "name": "Dihydroxyacetone", "id": "dha_c"}, {"formula": "C3H5O6P", "notes": {"original_bigg_ids": ["dhap[c]"]}, "compartment": "c", "name": "Dihydroxyacetone phosphate", "id": "dhap_c"}, {"formula": "C19H19N7O6", "notes": {"original_bigg_ids": ["dhf[c]"]}, "compartment": "c", "name": "7,8-Dihydrofolate", "id": "dhf_c"}, {"formula": "C9H13N5O4", "notes": {"original_bigg_ids": ["dhnpt[c]"]}, "compartment": "c", "name": "Dihydroneopterin", "id": "dhnpt_c"}, {"formula": "C5H5N2O4", "notes": {"original_bigg_ids": ["dhor_S[c]"]}, "compartment": "c", "name": "(S)-Dihydroorotate", "id": "dhor__S_c"}, {"formula": "C9H12N5O7P", "notes": {"original_bigg_ids": ["dhpmp[c]"]}, "compartment": "c", "name": "Dihydroneopterin monophosphate", "id": "dhpmp_c"}, {"formula": "C14H13N6O3", "notes": {"original_bigg_ids": ["dhpt[c]"]}, "compartment": "c", "name": "Dihydropteroate", "id": "dhpt_c"}, {"formula": "C12H22O14P", "notes": {"original_bigg_ids": ["dip_d_d[c]"]}, "compartment": "c", "name": "Di-myo-inositol 1,1' phosphate", "id": "dip_d_d_c"}, {"formula": "C13H18N4O6", "notes": {"original_bigg_ids": ["dmlz[c]"]}, "compartment": "c", "name": "6,7-Dimethyl-8-(1-D-ribityl)lumazine", "id": "dmlz_c"}, {"formula": "C41H77N2O9PRS", "notes": {"original_bigg_ids": ["dmosACP[c]"]}, "compartment": "c", "name": "13,14-Dimethyloctacosanedioic acid ACP (C30:0 ACP)", "id": "dmosACP_c"}, {"formula": "C5H9O7P2", "notes": {"original_bigg_ids": ["dmpp[c]"]}, "compartment": "c", "name": "Dimethylallyl diphosphate", "id": "dmpp_c"}, {"formula": "C43H81N2O9PRS", "notes": {"original_bigg_ids": ["dmtaACP[c]"]}, "compartment": "c", "name": "15,16-Dimethyltriacontanedioic acid ACP (C32:0 ACP)", "id": "dmtaACP_c"}, {"formula": "C21H24N6O15P2", "notes": {"original_bigg_ids": ["dnad[c]"]}, "compartment": "c", "name": "Deamino-NAD+", "id": "dnad_c"}, {"formula": "C21H33N7O13P2S", "notes": {"original_bigg_ids": ["dpcoa[c]"]}, "compartment": "c", "name": "Dephospho-CoA", "id": "dpcoa_c"}, {"formula": "C5H10O4", "notes": {"original_bigg_ids": ["drib[c]"]}, "compartment": "c", "name": "Deoxyribose C5H10O4", "id": "drib_c"}, {"formula": "C10H17N2O3", "notes": {"original_bigg_ids": ["dtbt[c]"]}, "compartment": "c", "name": "Dethiobiotin", "id": "dtbt_c"}, {"formula": "C10H13N2O11P2", "notes": {"original_bigg_ids": ["dtdp[c]"]}, "compartment": "c", "name": "DTDP", "id": "dtdp_c"}, {"formula": "C10H13N2O8P", "notes": {"original_bigg_ids": ["dtmp[c]"]}, "compartment": "c", "name": "DTMP", "id": "dtmp_c"}, {"formula": "C10H13N2O14P3", "notes": {"original_bigg_ids": ["dttp[c]"]}, "compartment": "c", "name": "DTTP", "id": "dttp_c"}, {"formula": "C9H11N2O11P2", "notes": {"original_bigg_ids": ["dudp[c]"]}, "compartment": "c", "name": "DUDP", "id": "dudp_c"}, {"formula": "C9H11N2O8P", "notes": {"original_bigg_ids": ["dump[c]"]}, "compartment": "c", "name": "DUMP", "id": "dump_c"}, {"formula": "C9H12N2O5", "notes": {"original_bigg_ids": ["duri[c]"]}, "compartment": "c", "name": "Deoxyuridine", "id": "duri_c"}, {"formula": "C9H11N2O14P3", "notes": {"original_bigg_ids": ["dutp[c]"]}, "compartment": "c", "name": "DUTP", "id": "dutp_c"}, {"formula": "C5H9O7P", "notes": {"original_bigg_ids": ["dxyl5p[c]"]}, "compartment": "c", "name": "1-deoxy-D-xylulose 5-phosphate", "id": "dxyl5p_c"}, {"formula": "C5H8NO5", "notes": {"original_bigg_ids": ["e4hglu[c]"]}, "compartment": "c", "name": "L erythro 4 Hydroxyglutamate C5H8NO5", "id": "e4hglu_c"}, {"formula": "C4H7O7P", "notes": {"original_bigg_ids": ["e4p[c]"]}, "compartment": "c", "name": "D-Erythrose 4-phosphate", "id": "e4p_c"}, {"formula": "C6H9N2O6P", "notes": {"original_bigg_ids": ["eig3p[c]"]}, "compartment": "c", "name": "D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate", "id": "eig3p_c"}, {"formula": "C2H8NO", "notes": {"original_bigg_ids": ["etha[c]"]}, "compartment": "c", "name": "Ethanolamine", "id": "etha_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["f1p[c]"]}, "compartment": "c", "name": "D-Fructose 1-phosphate", "id": "f1p_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["f6p[c]"]}, "compartment": "c", "name": "D-Fructose 6-phosphate", "id": "f6p_c"}, {"formula": "C27H31N9O15P2", "notes": {"original_bigg_ids": ["fad[c]"]}, "compartment": "c", "name": "Flavin adenine dinucleotide oxidized", "id": "fad_c"}, {"formula": "C27H33N9O15P2", "notes": {"original_bigg_ids": ["fadh2[c]"]}, "compartment": "c", "name": "Flavin adenine dinucleotide reduced", "id": "fadh2_c"}, {"formula": "C6H12O5", "notes": {"original_bigg_ids": ["fcl_L[c]"]}, "compartment": "c", "name": "L-fuculose", "id": "fcl__L_c"}, {"formula": "C6H10O12P2", "notes": {"original_bigg_ids": ["fdp[c]"]}, "compartment": "c", "name": "D-Fructose 1,6-bisphosphate", "id": "fdp_c"}, {"formula": "Fe8S8X", "notes": {"original_bigg_ids": ["fdxo_4_2[c]"]}, "compartment": "c", "name": "Ferredoxin (oxidized form 4:2)", "id": "fdxo_4_2_c"}, {"formula": "Fe8S8X", "notes": {"original_bigg_ids": ["fdxr_4_2[c]"]}, "compartment": "c", "name": "Ferredoxin (reduced form 4:2)", "id": "fdxr_4_2_c"}, {"formula": "Fe", "notes": {"original_bigg_ids": ["fe3[c]"]}, "compartment": "c", "name": "Fe3+", "id": "fe3_c"}, {"formula": "C8H13N2O9P", "notes": {"original_bigg_ids": ["fgam[c]"]}, "compartment": "c", "name": "N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide", "id": "fgam_c"}, {"formula": "C6H9NO2SR", "notes": {"original_bigg_ids": ["fmettrna[c]"]}, "compartment": "c", "name": "N-Formylmethionyl-tRNA", "id": "fmettrna_c"}, {"formula": "C17H19N4O9P", "notes": {"original_bigg_ids": ["fmn[c]"]}, "compartment": "c", "name": "FMN", "id": "fmn_c"}, {"formula": "CH1O2", "notes": {"original_bigg_ids": ["for[c]"]}, "compartment": "c", "name": "Formate", "id": "for_c"}, {"formula": "C6H8N2O4", "notes": {"original_bigg_ids": ["forglu[c]"]}, "compartment": "c", "name": "N-Formimidoyl-L-glutamate", "id": "forglu_c"}, {"formula": "C8H15N3O8P", "notes": {"original_bigg_ids": ["fpram[c]"]}, "compartment": "c", "name": "2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine", "id": "fpram_c"}, {"formula": "C10H13N4O9P", "notes": {"original_bigg_ids": ["fprica[c]"]}, "compartment": "c", "name": "5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide", "id": "fprica_c"}, {"formula": "C15H25O7P2", "notes": {"original_bigg_ids": ["frdp[c]"]}, "compartment": "c", "name": "Farnesyl diphosphate", "id": "frdp_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["fru[c]"]}, "compartment": "c", "name": "D-Fructose", "id": "fru_c"}, {"formula": "C6H9O7", "notes": {"original_bigg_ids": ["fruur[c]"]}, "compartment": "c", "name": "D-Fructuronate", "id": "fruur_c"}, {"formula": "C6H12O5", "notes": {"original_bigg_ids": ["fuc_L[c]"]}, "compartment": "c", "name": "L-Fucose", "id": "fuc__L_c"}, {"formula": "C4H2O4", "notes": {"original_bigg_ids": ["fum[c]"]}, "compartment": "c", "name": "Fumarate", "id": "fum_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["g1p[c]"]}, "compartment": "c", "name": "D-Glucose 1-phosphate", "id": "g1p_c"}, {"formula": "C3H5O6P", "notes": {"original_bigg_ids": ["g3p[c]"]}, "compartment": "c", "name": "Glyceraldehyde 3-phosphate", "id": "g3p_c"}, {"formula": "C8H20NO6P", "notes": {"original_bigg_ids": ["g3pc[c]"]}, "compartment": "c", "name": "Sn-Glycero-3-phosphocholine", "id": "g3pc_c"}, {"formula": "C5H14NO6P", "notes": {"original_bigg_ids": ["g3pe[c]"]}, "compartment": "c", "name": "Sn-Glycero-3-phosphoethanolamine", "id": "g3pe_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["g6p[c]"]}, "compartment": "c", "name": "D-Glucose 6-phosphate", "id": "g6p_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["gal[c]"]}, "compartment": "c", "name": "D-Galactose", "id": "gal_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["gal_bD[c]"]}, "compartment": "c", "name": "Beta D-Galactose", "id": "gal_bD_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["gal1p[c]"]}, "compartment": "c", "name": "Alpha-D-Galactose 1-phosphate", "id": "gal1p_c"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["galman4[c]"]}, "compartment": "c", "name": "Galactomannan(n=4 repeat units mannose, alpha-1,4 man)", "id": "galman4_c"}, {"formula": "C36H62O31", "notes": {"original_bigg_ids": ["galman6[c]"]}, "compartment": "c", "name": "Galactomannan(n=6 repeat units mannose, alpha-1,4 man)", "id": "galman6_c"}, {"formula": "C6H9O7", "notes": {"original_bigg_ids": ["galur[c]"]}, "compartment": "c", "name": "D-Galacturonate", "id": "galur_c"}, {"formula": "C6H13NO8P", "notes": {"original_bigg_ids": ["gam1p[c]"]}, "compartment": "c", "name": "D-Glucosamine 1-phosphate", "id": "gam1p_c"}, {"formula": "C6H13NO8P", "notes": {"original_bigg_ids": ["gam6p[c]"]}, "compartment": "c", "name": "D-Glucosamine 6-phosphate", "id": "gam6p_c"}, {"formula": "C7H14N2O8P", "notes": {"original_bigg_ids": ["gar[c]"]}, "compartment": "c", "name": "N1-(5-Phospho-D-ribosyl)glycinamide", "id": "gar_c"}, {"formula": "C2H4O2", "notes": {"original_bigg_ids": ["gcald[c]"]}, "compartment": "c", "name": "Glycolaldehyde", "id": "gcald_c"}, {"formula": "C10H12N5O11P2", "notes": {"original_bigg_ids": ["gdp[c]"]}, "compartment": "c", "name": "GDP", "id": "gdp_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["glc_D[c]"]}, "compartment": "c", "name": "D-Glucose", "id": "glc__D_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["glc_bD[c]"]}, "compartment": "c", "name": "Beta D-glucose", "id": "glc_bD_c"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["glcman4[c]"]}, "compartment": "c", "name": "Glucomannan (n=4 repeat units, glc beta-1,4 man)", "id": "glcman4_c"}, {"formula": "C36H62O31", "notes": {"original_bigg_ids": ["glcman6[c]"]}, "compartment": "c", "name": "Glucomannan (n=6 repeat units, glc beta-1,4 man)", "id": "glcman6_c"}, {"formula": "C6H11O7", "notes": {"original_bigg_ids": ["glcn[c]"]}, "compartment": "c", "name": "D-Gluconate", "id": "glcn_c"}, {"formula": "C6H9O7", "notes": {"original_bigg_ids": ["glcur[c]"]}, "compartment": "c", "name": "D-Glucuronate", "id": "glcur_c"}, {"formula": "C5H10N2O3", "notes": {"original_bigg_ids": ["gln_L[c]"]}, "compartment": "c", "name": "L-Glutamine", "id": "gln__L_c"}, {"formula": "C5H9N2O2R", "notes": {"original_bigg_ids": ["glntrna[c]"]}, "compartment": "c", "name": "L-Glutaminyl-tRNA(Gln)", "id": "glntrna_c"}, {"formula": "C5H8NO4", "notes": {"original_bigg_ids": ["glu_D[c]"]}, "compartment": "c", "name": "D-Glutamate", "id": "glu__D_c"}, {"formula": "C5H8NO4", "notes": {"original_bigg_ids": ["glu_L[c]"]}, "compartment": "c", "name": "L-Glutamate", "id": "glu__L_c"}, {"formula": "C5H8NO7P", "notes": {"original_bigg_ids": ["glu5p[c]"]}, "compartment": "c", "name": "L-Glutamate 5-phosphate", "id": "glu5p_c"}, {"formula": "C5H9NO3", "notes": {"original_bigg_ids": ["glu5sa[c]"]}, "compartment": "c", "name": "L-Glutamate 5-semialdehyde", "id": "glu5sa_c"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["glucan4[c]"]}, "compartment": "c", "name": "Beta-1,3/1,4-glucan (Barley, n=4, Glc beta1->3,4 Glc)", "id": "glucan4_c"}, {"formula": "C36H62O31", "notes": {"original_bigg_ids": ["glucan6[c]"]}, "compartment": "c", "name": "Beta-1,3/1,4-glucan (Barley, n=6, Glc beta1->3,4 Glc)", "id": "glucan6_c"}, {"formula": "C5H7NO3R", "notes": {"original_bigg_ids": ["glutrna[c]"]}, "compartment": "c", "name": "L-Glutamyl-tRNA(Glu)", "id": "glutrna_c"}, {"formula": "None", "notes": {"original_bigg_ids": ["glutrna_gln_[c]"]}, "compartment": "c", "name": "L-Glutamyl-tRNA(Gln)", "id": "glutrna_gln_c"}, {"formula": "C2H1O3", "notes": {"original_bigg_ids": ["glx[c]"]}, "compartment": "c", "name": "Glyoxylate", "id": "glx_c"}, {"formula": "C2H5NO2", "notes": {"original_bigg_ids": ["gly[c]"]}, "compartment": "c", "name": "Glycine", "id": "gly_c"}, {"formula": "C3H6O3", "notes": {"original_bigg_ids": ["glyald[c]"]}, "compartment": "c", "name": "D-Glyceraldehyde", "id": "glyald_c"}, {"formula": "C3H8O3", "notes": {"original_bigg_ids": ["glyc[c]"]}, "compartment": "c", "name": "Glycerol", "id": "glyc_c"}, {"formula": "C3H5O4", "notes": {"original_bigg_ids": ["glyc_R[c]"]}, "compartment": "c", "name": "(R)-Glycerate", "id": "glyc__R_c"}, {"formula": "C3H7O6P", "notes": {"original_bigg_ids": ["glyc3p[c]"]}, "compartment": "c", "name": "Glycerol 3-phosphate", "id": "glyc3p_c"}, {"formula": "C6H10O5", "notes": {"original_bigg_ids": ["glycogen[c]"]}, "compartment": "c", "name": "Glycogen", "id": "glycogen_c"}, {"formula": "C2H4NOR", "notes": {"original_bigg_ids": ["glytrna[c]"]}, "compartment": "c", "name": "Glycyl-tRNA(Gly)", "id": "glytrna_c"}, {"formula": "C10H12N5O8P", "notes": {"original_bigg_ids": ["gmp[c]"]}, "compartment": "c", "name": "GMP", "id": "gmp_c"}, {"formula": "C10H17O7P2", "notes": {"original_bigg_ids": ["grdp[c]"]}, "compartment": "c", "name": "Geranyl diphosphate", "id": "grdp_c"}, {"formula": "C10H13N5O5", "notes": {"original_bigg_ids": ["gsn[c]"]}, "compartment": "c", "name": "Guanosine", "id": "gsn_c"}, {"formula": "C10H12N5O14P3", "notes": {"original_bigg_ids": ["gtp[c]"]}, "compartment": "c", "name": "GTP", "id": "gtp_c"}, {"formula": "C5H5N5O", "notes": {"original_bigg_ids": ["gua[c]"]}, "compartment": "c", "name": "Guanine", "id": "gua_c"}, {"formula": "H", "notes": {"original_bigg_ids": ["h[c]"]}, "compartment": "c", "name": "H+", "id": "h_c"}, {"formula": "H2", "notes": {"original_bigg_ids": ["h2[c]"]}, "compartment": "c", "name": "H2", "id": "h2_c"}, {"formula": "C5H9O8P2", "notes": {"original_bigg_ids": ["h2mb4p[c]"]}, "compartment": "c", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate", "id": "h2mb4p_c"}, {"formula": "H2O", "notes": {"original_bigg_ids": ["h2o[c]"]}, "compartment": "c", "name": "H2O", "id": "h2o_c"}, {"formula": "H2O2", "notes": {"original_bigg_ids": ["h2o2[c]"]}, "compartment": "c", "name": "Hydrogen peroxide", "id": "h2o2_c"}, {"formula": "H2S", "notes": {"original_bigg_ids": ["h2s[c]"]}, "compartment": "c", "name": "Hydrogen sulfide", "id": "h2s_c"}, {"formula": "CHO3", "notes": {"original_bigg_ids": ["hco3[c]"]}, "compartment": "c", "name": "Bicarbonate", "id": "hco3_c"}, {"formula": "C4H9NO2S", "notes": {"original_bigg_ids": ["hcys_L[c]"]}, "compartment": "c", "name": "L-Homocysteine", "id": "hcys__L_c"}, {"formula": "C27H49N2O8PRS", "notes": {"original_bigg_ids": ["hdeACP[c]"]}, "compartment": "c", "name": "Cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)", "id": "hdeACP_c"}, {"formula": "C6H9N3O2", "notes": {"original_bigg_ids": ["his_L[c]"]}, "compartment": "c", "name": "L-Histidine", "id": "his__L_c"}, {"formula": "C6H11N3O4P", "notes": {"original_bigg_ids": ["hisp[c]"]}, "compartment": "c", "name": "L-Histidinol phosphate", "id": "hisp_c"}, {"formula": "C6H12N3O", "notes": {"original_bigg_ids": ["histd[c]"]}, "compartment": "c", "name": "L-Histidinol", "id": "histd_c"}, {"formula": "C6H8N3OR", "notes": {"original_bigg_ids": ["histrna[c]"]}, "compartment": "c", "name": "L-Histidyl-tRNA(His)", "id": "histrna_c"}, {"formula": "C4H9NO3", "notes": {"original_bigg_ids": ["hom_L[c]"]}, "compartment": "c", "name": "L-Homoserine", "id": "hom__L_c"}, {"formula": "C3H3O4", "notes": {"original_bigg_ids": ["hpyr[c]"]}, "compartment": "c", "name": "Hydroxypyruvate", "id": "hpyr_c"}, {"formula": "C5H4N4O", "notes": {"original_bigg_ids": ["hxan[c]"]}, "compartment": "c", "name": "Hypoxanthine", "id": "hxan_c"}, {"formula": "C4H3NO4", "notes": {"original_bigg_ids": ["iasp[c]"]}, "compartment": "c", "name": "Iminoaspartate", "id": "iasp_c"}, {"formula": "C6H5O7", "notes": {"original_bigg_ids": ["icit[c]"]}, "compartment": "c", "name": "Isocitrate", "id": "icit_c"}, {"formula": "C6H13NO2", "notes": {"original_bigg_ids": ["ile_L[c]"]}, "compartment": "c", "name": "L-Isoleucine", "id": "ile__L_c"}, {"formula": "C6H12NOR", "notes": {"original_bigg_ids": ["iletrna[c]"]}, "compartment": "c", "name": "L-Isoleucyl-tRNA(Ile)", "id": "iletrna_c"}, {"formula": "C6H7N2O5P", "notes": {"original_bigg_ids": ["imacp[c]"]}, "compartment": "c", "name": "3-(Imidazol-4-yl)-2-oxopropyl phosphate", "id": "imacp_c"}, {"formula": "C10H11N4O8P", "notes": {"original_bigg_ids": ["imp[c]"]}, "compartment": "c", "name": "IMP", "id": "imp_c"}, {"formula": "C8H7N", "notes": {"original_bigg_ids": ["indole[c]"]}, "compartment": "c", "name": "Indole", "id": "indole_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["inost[c]"]}, "compartment": "c", "name": "Myo-Inositol", "id": "inost_c"}, {"formula": "C10H12N4O5", "notes": {"original_bigg_ids": ["ins[c]"]}, "compartment": "c", "name": "Inosine", "id": "ins_c"}, {"formula": "C5H9O7P2", "notes": {"original_bigg_ids": ["ipdp[c]"]}, "compartment": "c", "name": "Isopentenyl diphosphate", "id": "ipdp_c"}, {"formula": "K", "notes": {"original_bigg_ids": ["k[c]"]}, "compartment": "c", "name": "Potassium", "id": "k_c"}, {"formula": "C247H393N17O213S12X", "notes": {"original_bigg_ids": ["ksi[c]"]}, "compartment": "c", "name": "Ksi e", "id": "ksi_c"}, {"formula": "C241H383N17O209S12X", "notes": {"original_bigg_ids": ["ksi_deg1[c]"]}, "compartment": "c", "name": "Ksi deg1 e", "id": "ksi_deg1_c"}, {"formula": "C3H5O3", "notes": {"original_bigg_ids": ["lac_L[c]"]}, "compartment": "c", "name": "L-Lactate", "id": "lac__L_c"}, {"formula": "C3H6O2", "notes": {"original_bigg_ids": ["lald_L[c]"]}, "compartment": "c", "name": "L-Lactaldehyde", "id": "lald__L_c"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["lcts[c]"]}, "compartment": "c", "name": "Lactose", "id": "lcts_c"}, {"formula": "C6H13NO2", "notes": {"original_bigg_ids": ["leu_L[c]"]}, "compartment": "c", "name": "L-Leucine", "id": "leu__L_c"}, {"formula": "C6H12NOR", "notes": {"original_bigg_ids": ["leutrna[c]"]}, "compartment": "c", "name": "L-Leucyl-tRNA(Leu)", "id": "leutrna_c"}, {"formula": "C35H67N2O8PRS", "notes": {"original_bigg_ids": ["lgnACP[c]"]}, "compartment": "c", "name": "Tetracosanoyl-ACP (n-C24:0)", "id": "lgnACP_c"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["lmn2[c]"]}, "compartment": "c", "name": "Laminaribiose", "id": "lmn2_c"}, {"formula": "C6H15N2O2", "notes": {"original_bigg_ids": ["lys_L[c]"]}, "compartment": "c", "name": "L-Lysine", "id": "lys__L_c"}, {"formula": "C6H14N2OR", "notes": {"original_bigg_ids": ["lystrna[c]"]}, "compartment": "c", "name": "L-Lysine-tRNA (Lys)", "id": "lystrna_c"}, {"formula": "C4H4O5", "notes": {"original_bigg_ids": ["mal_L[c]"]}, "compartment": "c", "name": "L-Malate", "id": "mal__L_c"}, {"formula": "C14H22N2O10PRS", "notes": {"original_bigg_ids": ["malACP[c]"]}, "compartment": "c", "name": "Malonyl-[acyl-carrier protein]", "id": "malACP_c"}, {"formula": "C24H33N7O19P3S", "notes": {"original_bigg_ids": ["malcoa[c]"]}, "compartment": "c", "name": "Malonyl-CoA", "id": "malcoa_c"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["malt[c]"]}, "compartment": "c", "name": "Maltose", "id": "malt_c"}, {"formula": "C18H32O16", "notes": {"original_bigg_ids": ["malttr[c]"]}, "compartment": "c", "name": "Maltotriose", "id": "malttr_c"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["maltttr[c]"]}, "compartment": "c", "name": "Maltotetraose", "id": "maltttr_c"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["man[c]"]}, "compartment": "c", "name": "D-Mannose", "id": "man_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["man6p[c]"]}, "compartment": "c", "name": "D-Mannose 6-phosphate", "id": "man6p_c"}, {"formula": "C6H11O7", "notes": {"original_bigg_ids": ["mana[c]"]}, "compartment": "c", "name": "D-Mannonate", "id": "mana_c"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["manb[c]"]}, "compartment": "c", "name": "Mannobiose (beta-1,4)", "id": "manb_c"}, {"formula": "C18H32O16", "notes": {"original_bigg_ids": ["mantr[c]"]}, "compartment": "c", "name": "Mannotriose (beta-1,4)", "id": "mantr_c"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["manttr[c]"]}, "compartment": "c", "name": "Mannotetraose", "id": "manttr_c"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["melib[c]"]}, "compartment": "c", "name": "Melibiose", "id": "melib_c"}, {"formula": "C3H5O3S", "notes": {"original_bigg_ids": ["mercplac[c]"]}, "compartment": "c", "name": "Mercplac c", "id": "mercplac_c"}, {"formula": "C3H3O3S", "notes": {"original_bigg_ids": ["mercppyr[c]"]}, "compartment": "c", "name": "Mercaptopyruvate", "id": "mercppyr_c"}, {"formula": "C5H11NO2S", "notes": {"original_bigg_ids": ["met_L[c]"]}, "compartment": "c", "name": "L-Methionine", "id": "met__L_c"}, {"formula": "C20H20N7O6", "notes": {"original_bigg_ids": ["methf[c]"]}, "compartment": "c", "name": "5,10-Methenyltetrahydrofolate", "id": "methf_c"}, {"formula": "C5H10NOSR", "notes": {"original_bigg_ids": ["mettrna[c]"]}, "compartment": "c", "name": "L-Methionyl-tRNA (Met)", "id": "mettrna_c"}, {"formula": "Mg", "notes": {"original_bigg_ids": ["mg2[c]"]}, "compartment": "c", "name": "Magnesium", "id": "mg2_c"}, {"formula": "C6H11O9P", "notes": {"original_bigg_ids": ["mi1p_L[c]"]}, "compartment": "c", "name": "L-myo-Inositol 1-phosphate", "id": "mi1p__L_c"}, {"formula": "C20H21N7O6", "notes": {"original_bigg_ids": ["mlthf[c]"]}, "compartment": "c", "name": "5,10-Methylenetetrahydrofolate", "id": "mlthf_c"}, {"formula": "C25H35N7O19P3S", "notes": {"original_bigg_ids": ["mmcoa_S[c]"]}, "compartment": "c", "name": "(S)-Methylmalonyl-CoA", "id": "mmcoa__S_c"}, {"formula": "C6H14O6", "notes": {"original_bigg_ids": ["mnl[c]"]}, "compartment": "c", "name": "D-Mannitol", "id": "mnl_c"}, {"formula": "C3H4O2", "notes": {"original_bigg_ids": ["mthgxl[c]"]}, "compartment": "c", "name": "Methylglyoxal", "id": "mthgxl_c"}, {"formula": "C25H47N2O8PRS", "notes": {"original_bigg_ids": ["myrsACP[c]"]}, "compartment": "c", "name": "Myristoyl-ACP (n-C14:0ACP)", "id": "myrsACP_c"}, {"formula": "C9H15N2O5", "notes": {"original_bigg_ids": ["n6all26d[c]"]}, "compartment": "c", "name": "N6-Acetyl-LL-2,6-diaminoheptanedioate", "id": "n6all26d_c"}, {"formula": "Na", "notes": {"original_bigg_ids": ["na1[c]"]}, "compartment": "c", "name": "Sodium", "id": "na1_c"}, {"formula": "C6H4NO2", "notes": {"original_bigg_ids": ["nac[c]"]}, "compartment": "c", "name": "Nicotinate", "id": "nac_c"}, {"formula": "C21H26N7O14P2", "notes": {"original_bigg_ids": ["nad[c]"]}, "compartment": "c", "name": "Nicotinamide adenine dinucleotide", "id": "nad_c"}, {"formula": "C21H27N7O14P2", "notes": {"original_bigg_ids": ["nadh[c]"]}, "compartment": "c", "name": "Nicotinamide adenine dinucleotide - reduced", "id": "nadh_c"}, {"formula": "C21H25N7O17P3", "notes": {"original_bigg_ids": ["nadp[c]"]}, "compartment": "c", "name": "Nicotinamide adenine dinucleotide phosphate", "id": "nadp_c"}, {"formula": "C21H26N7O17P3", "notes": {"original_bigg_ids": ["nadph[c]"]}, "compartment": "c", "name": "Nicotinamide adenine dinucleotide phosphate - reduced", "id": "nadph_c"}, {"formula": "C9H11NO6", "notes": {"original_bigg_ids": ["nal2a6o[c]"]}, "compartment": "c", "name": "N-Acetyl-L-2-amino-6-oxopimelate", "id": "nal2a6o_c"}, {"formula": "C6H6N2O", "notes": {"original_bigg_ids": ["ncam[c]"]}, "compartment": "c", "name": "Nicotinamide", "id": "ncam_c"}, {"formula": "H3N", "notes": {"original_bigg_ids": ["nh3[c]"]}, "compartment": "c", "name": "Ammonia", "id": "nh3_c"}, {"formula": "H4N", "notes": {"original_bigg_ids": ["nh4[c]"]}, "compartment": "c", "name": "Ammonium", "id": "nh4_c"}, {"formula": "C11H13NO6", "notes": {"original_bigg_ids": ["nicrns[c]"]}, "compartment": "c", "name": "Nicotinate D-ribonucleoside", "id": "nicrns_c"}, {"formula": "C11H12NO9P", "notes": {"original_bigg_ids": ["nicrnt[c]"]}, "compartment": "c", "name": "Nicotinate D-ribonucleotide", "id": "nicrnt_c"}, {"formula": "C11H14N2O8P", "notes": {"original_bigg_ids": ["nmn[c]"]}, "compartment": "c", "name": "NMN", "id": "nmn_c"}, {"formula": "O2", "notes": {"original_bigg_ids": ["o2[c]"]}, "compartment": "c", "name": "O2", "id": "o2_c"}, {"formula": "C4H2O5", "notes": {"original_bigg_ids": ["oaa[c]"]}, "compartment": "c", "name": "Oxaloacetate", "id": "oaa_c"}, {"formula": "C29H55N2O8PRS", "notes": {"original_bigg_ids": ["ocdcaACP[c]"]}, "compartment": "c", "name": "Octadecanoyl-ACP (n-C18:0ACP)", "id": "ocdcaACP_c"}, {"formula": "C29H51N2O8PRS", "notes": {"original_bigg_ids": ["ocdcyaACP[c]"]}, "compartment": "c", "name": "Octadecynoyl ACP  n C182ACP  C29H51N2O8PRS", "id": "ocdcyaACP_c"}, {"formula": "C40H65O7P2", "notes": {"original_bigg_ids": ["octdp[c]"]}, "compartment": "c", "name": "All-trans-Octaprenyl diphosphate", "id": "octdp_c"}, {"formula": "C29H53N2O8PRS", "notes": {"original_bigg_ids": ["octeACP[c]"]}, "compartment": "c", "name": "Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)", "id": "octeACP_c"}, {"formula": "C5H13N2O2", "notes": {"original_bigg_ids": ["orn[c]"]}, "compartment": "c", "name": "Ornithine", "id": "orn_c"}, {"formula": "C5H3N2O4", "notes": {"original_bigg_ids": ["orot[c]"]}, "compartment": "c", "name": "Orotate", "id": "orot_c"}, {"formula": "C10H10N2O11P", "notes": {"original_bigg_ids": ["orot5p[c]"]}, "compartment": "c", "name": "Orotidine 5'-phosphate", "id": "orot5p_c"}, {"formula": "C2O4", "notes": {"original_bigg_ids": ["oxa[c]"]}, "compartment": "c", "name": "Oxalate", "id": "oxa_c"}, {"formula": "C35H67O8P1", "notes": {"original_bigg_ids": ["pa160[c]"]}, "compartment": "c", "name": "1,2-dihexadecanoyl-sn-glycerol 3-phosphate", "id": "pa160_c"}, {"formula": "C27H51N2O8PRS", "notes": {"original_bigg_ids": ["palmACP[c]"]}, "compartment": "c", "name": "Palmitoyl-ACP (n-C16:0ACP)", "id": "palmACP_c"}, {"formula": "C11H21N2O7PS", "notes": {"original_bigg_ids": ["pan4p[c]"]}, "compartment": "c", "name": "Pantetheine 4'-phosphate", "id": "pan4p_c"}, {"formula": "C6H11O4", "notes": {"original_bigg_ids": ["pant_R[c]"]}, "compartment": "c", "name": "(R)-Pantoate", "id": "pant__R_c"}, {"formula": "C10H11N5O10P2", "notes": {"original_bigg_ids": ["pap[c]"]}, "compartment": "c", "name": "Adenosine 3',5'-bisphosphate", "id": "pap_c"}, {"formula": "C4H9N3O5P", "notes": {"original_bigg_ids": ["pcreat[c]"]}, "compartment": "c", "name": "Pcreat c", "id": "pcreat_c"}, {"formula": "C12H21O17P2", "notes": {"original_bigg_ids": ["pdip_d_d[c]"]}, "compartment": "c", "name": "Phospho-di-myo-inositol 1,1' phosphate", "id": "pdip_d_d_c"}, {"formula": "C3H2O6P", "notes": {"original_bigg_ids": ["pep[c]"]}, "compartment": "c", "name": "Phosphoenolpyruvate", "id": "pep_c"}, {"formula": "C39H63N8O19", "notes": {"original_bigg_ids": ["peptido_TM[c]"]}, "compartment": "c", "name": "Peptidoglycan subunit of Thermotoga maritima", "id": "peptido_TM_c"}, {"formula": "C38H73O13P2", "notes": {"original_bigg_ids": ["pgp160[c]"]}, "compartment": "c", "name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "id": "pgp160_c"}, {"formula": "C9H11NO2", "notes": {"original_bigg_ids": ["phe_L[c]"]}, "compartment": "c", "name": "L-Phenylalanine", "id": "phe__L_c"}, {"formula": "C9H10NOR", "notes": {"original_bigg_ids": ["phetrna[c]"]}, "compartment": "c", "name": "L-Phenylalanyl-tRNA(Phe)", "id": "phetrna_c"}, {"formula": "C4H8NO6P", "notes": {"original_bigg_ids": ["phom[c]"]}, "compartment": "c", "name": "O-Phospho-L-homoserine", "id": "phom_c"}, {"formula": "C9H7O3", "notes": {"original_bigg_ids": ["phpyr[c]"]}, "compartment": "c", "name": "Phenylpyruvate", "id": "phpyr_c"}, {"formula": "HO4P", "notes": {"original_bigg_ids": ["pi[c]"]}, "compartment": "c", "name": "Phosphate", "id": "pi_c"}, {"formula": "C9H16NO5", "notes": {"original_bigg_ids": ["pnto_R[c]"]}, "compartment": "c", "name": "(R)-Pantothenate", "id": "pnto__R_c"}, {"formula": "C24H36N7O17P3S", "notes": {"original_bigg_ids": ["ppcoa[c]"]}, "compartment": "c", "name": "Propanoyl-CoA", "id": "ppcoa_c"}, {"formula": "C10H8O6", "notes": {"original_bigg_ids": ["pphn[c]"]}, "compartment": "c", "name": "Prephenate", "id": "pphn_c"}, {"formula": "HO7P2", "notes": {"original_bigg_ids": ["ppi[c]"]}, "compartment": "c", "name": "Diphosphate", "id": "ppi_c"}, {"formula": "HO10P3", "notes": {"original_bigg_ids": ["pppi[c]"]}, "compartment": "c", "name": "Inorganic triphosphate", "id": "pppi_c"}, {"formula": "C5H11NO7P", "notes": {"original_bigg_ids": ["pram[c]"]}, "compartment": "c", "name": "5-Phospho-beta-D-ribosylamine", "id": "pram_c"}, {"formula": "C12H13NO9P", "notes": {"original_bigg_ids": ["pran[c]"]}, "compartment": "c", "name": "N-(5-Phospho-D-ribosyl)anthranilate", "id": "pran_c"}, {"formula": "C15H19N5O14P2", "notes": {"original_bigg_ids": ["prbamp[c]"]}, "compartment": "c", "name": "1-(5-Phosphoribosyl)-AMP", "id": "prbamp_c"}, {"formula": "C15H19N5O20P4", "notes": {"original_bigg_ids": ["prbatp[c]"]}, "compartment": "c", "name": "1-(5-Phosphoribosyl)-ATP", "id": "prbatp_c"}, {"formula": "C15H21N5O15P2", "notes": {"original_bigg_ids": ["prfp[c]"]}, "compartment": "c", "name": "1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide", "id": "prfp_c"}, {"formula": "C15H21N5O15P2", "notes": {"original_bigg_ids": ["prlp[c]"]}, "compartment": "c", "name": "5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide", "id": "prlp_c"}, {"formula": "C5H9NO2", "notes": {"original_bigg_ids": ["pro_L[c]"]}, "compartment": "c", "name": "L-Proline", "id": "pro__L_c"}, {"formula": "C5H8NOR", "notes": {"original_bigg_ids": ["protrna[c]"]}, "compartment": "c", "name": "L-Prolyl-tRNA(Pro)", "id": "protrna_c"}, {"formula": "C5H8O14P3", "notes": {"original_bigg_ids": ["prpp[c]"]}, "compartment": "c", "name": "5-Phospho-alpha-D-ribose 1-diphosphate", "id": "prpp_c"}, {"formula": "C4H14N2", "notes": {"original_bigg_ids": ["ptrc[c]"]}, "compartment": "c", "name": "Putrescine", "id": "ptrc_c"}, {"formula": "C8H8NO6P", "notes": {"original_bigg_ids": ["pydx5p[c]"]}, "compartment": "c", "name": "Pyridoxal 5'-phosphate", "id": "pydx5p_c"}, {"formula": "C3H3O3", "notes": {"original_bigg_ids": ["pyr[c]"]}, "compartment": "c", "name": "Pyruvate", "id": "pyr_c"}, {"formula": "C14H18O4", "notes": {"original_bigg_ids": ["q[c]"]}, "compartment": "c", "name": "Ubiquinone", "id": "q_c"}, {"formula": "C14H20O4", "notes": {"original_bigg_ids": ["qh2[c]"]}, "compartment": "c", "name": "Ubiquinol", "id": "qh2_c"}, {"formula": "C7H3NO4", "notes": {"original_bigg_ids": ["quln[c]"]}, "compartment": "c", "name": "Quinolinate", "id": "quln_c"}, {"formula": "C5H9O8P", "notes": {"original_bigg_ids": ["r1p[c]"]}, "compartment": "c", "name": "Alpha-D-Ribose 1-phosphate", "id": "r1p_c"}, {"formula": "C5H9O8P", "notes": {"original_bigg_ids": ["r5p[c]"]}, "compartment": "c", "name": "Alpha-D-Ribose 5-phosphate", "id": "r5p_c"}, {"formula": "C18H32O16", "notes": {"original_bigg_ids": ["raffin[c]"]}, "compartment": "c", "name": "Raffinose C18H32O16", "id": "raffin_c"}, {"formula": "C5H10O5", "notes": {"original_bigg_ids": ["rbl_L[c]"]}, "compartment": "c", "name": "L-Ribulose", "id": "rbl__L_c"}, {"formula": "C9H17NO6S", "notes": {"original_bigg_ids": ["rhcys[c]"]}, "compartment": "c", "name": "S-Ribosyl-L-homocysteine", "id": "rhcys_c"}, {"formula": "C5H10O5", "notes": {"original_bigg_ids": ["rib_D[c]"]}, "compartment": "c", "name": "D-Ribose", "id": "rib__D_c"}, {"formula": "C17H20N4O6", "notes": {"original_bigg_ids": ["ribflv[c]"]}, "compartment": "c", "name": "Riboflavin", "id": "ribflv_c"}, {"formula": "C6H12O5", "notes": {"original_bigg_ids": ["rml[c]"]}, "compartment": "c", "name": "L-Rhamnulose", "id": "rml_c"}, {"formula": "C6H11O8P", "notes": {"original_bigg_ids": ["rml1p[c]"]}, "compartment": "c", "name": "L-Rhamnulose 1-phosphate", "id": "rml1p_c"}, {"formula": "C6H12O5", "notes": {"original_bigg_ids": ["rmn[c]"]}, "compartment": "c", "name": "L-Rhamnose", "id": "rmn_c"}, {"formula": "C11H15N2O5", "notes": {"original_bigg_ids": ["rnam[c]"]}, "compartment": "c", "name": "N Ribosylnicotinamide C11H15N2O5", "id": "rnam_c"}, {"formula": "C5H9O8P", "notes": {"original_bigg_ids": ["ru5p_D[c]"]}, "compartment": "c", "name": "D-Ribulose 5-phosphate", "id": "ru5p__D_c"}, {"formula": "C5H9O8P", "notes": {"original_bigg_ids": ["ru5p_L[c]"]}, "compartment": "c", "name": "L-Ribulose 5-phosphate", "id": "ru5p__L_c"}, {"formula": "S", "notes": {"original_bigg_ids": ["s[c]"]}, "compartment": "c", "name": "Sulfur", "id": "s_c"}, {"formula": "C7H12O13P2", "notes": {"original_bigg_ids": ["s17bp[c]"]}, "compartment": "c", "name": "Sedoheptulose 1,7-bisphosphate", "id": "s17bp_c"}, {"formula": "C90H145N6O65X", "notes": {"original_bigg_ids": ["s2l2fn2m2masn[c]"]}, "compartment": "c", "name": "S2l2fn2m2masn e", "id": "s2l2fn2m2masn_c"}, {"formula": "C84H135N6O61X", "notes": {"original_bigg_ids": ["s2l2n2m2masn[c]"]}, "compartment": "c", "name": "S2l2n2m2masn e", "id": "s2l2n2m2masn_c"}, {"formula": "C7H13O10P", "notes": {"original_bigg_ids": ["s7p[c]"]}, "compartment": "c", "name": "Sedoheptulose 7-phosphate", "id": "s7p_c"}, {"formula": "C3H7NO3", "notes": {"original_bigg_ids": ["ser_L[c]"]}, "compartment": "c", "name": "L-Serine", "id": "ser__L_c"}, 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["leu_L[e]"]}, "compartment": "e", "name": "L-Leucine", "id": "leu__L_e"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["lmn2[e]"]}, "compartment": "e", "name": "Laminaribiose", "id": "lmn2_e"}, {"formula": "C180H302O151", "notes": {"original_bigg_ids": ["lmn30[e]"]}, "compartment": "e", "name": "Laminarin (n=30 repeat units, beta -1,3 glc)", "id": "lmn30_e"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["malt[e]"]}, "compartment": "e", "name": "Maltose", "id": "malt_e"}, {"formula": "C18H32O16", "notes": {"original_bigg_ids": ["malttr[e]"]}, "compartment": "e", "name": "Maltotriose", "id": "malttr_e"}, {"formula": "C24H42O21", "notes": {"original_bigg_ids": ["maltttr[e]"]}, "compartment": "e", "name": "Maltotetraose", "id": "maltttr_e"}, {"formula": "C6H12O6", "notes": {"original_bigg_ids": ["man[e]"]}, "compartment": "e", "name": "D-Mannose", "id": "man_e"}, {"formula": "C12H22O11", "notes": {"original_bigg_ids": ["manb[e]"]}, "compartment": "e", "name": 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