{"reactions": [{"subsystem": "Transport; Outer Membrane Porin", "name": "(R)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["12PPDRtex"]}, "metabolites": {"12ppd__R_e": -1.0, "12ppd__R_p": 1.0}, "id": "12PPDRtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Inner Membrane", "name": "(R)-Propane-1,2-diol facilitated transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["12PPDRtpp"]}, "metabolites": {"12ppd__R_c": 1.0, "12ppd__R_p": -1.0}, "id": "12PPDRtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Outer Membrane Porin", "name": "(S)-Propane-1,2-diol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["12PPDStex"]}, "metabolites": {"12ppd__S_e": -1.0, "12ppd__S_p": 1.0}, "id": "12PPDStex", "gene_reaction_rule": "YPO1222"}, 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{"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (butanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD1f"]}, "metabolites": {"btcoa_c": -1.0, "fadh2_c": 1.0, "b2coa_c": 1.0, "fad_c": -1.0}, "id": "ACOAD1f", "gene_reaction_rule": "YPO3244"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD2f"]}, "metabolites": {"fadh2_c": 1.0, "hxcoa_c": -1.0, "fad_c": -1.0, "hx2coa_c": 1.0}, "id": "ACOAD2f", "gene_reaction_rule": "YPO3244"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD3f"]}, "metabolites": {"oc2coa_c": 1.0, "fadh2_c": 1.0, "occoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD3f", "gene_reaction_rule": "YPO3244"}, {"subsystem": "Membrane Lipid Metabolism", "name": 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{"subsystem": "Transport; Inner Membrane", "name": "Adenosylcobalamin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "adocbl_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "adocbl_p": -1.0, "pi_c": 1.0}, "id": "ADOCBLabcpp", "gene_reaction_rule": "YPO2425 and YPO2423 and YPO3385"}, {"subsystem": "Transport; Outer Membrane", "name": "Adenosylcobalimin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLtonex"]}, "metabolites": {"adocbl_p": 1.0, "h_c": 1.0, "h_p": -1.0, "adocbl_e": -1.0}, "id": "ADOCBLtonex", "gene_reaction_rule": "YPO2193 and YPO0683 and YPO0682"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ADPribose diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPRDP"]}, "metabolites": {"h2o_c": -1.0, "r5p_c": 1.0, "amp_c": 1.0, "adprib_c": -1.0, 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{"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT120"]}, "metabolites": {"1ddecg3p_c": -1.0, "ACP_c": 1.0, "pa120_c": 1.0, "ddcaACP_c": -1.0}, "id": "AGPAT120", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT140"]}, "metabolites": {"1tdecg3p_c": -1.0, "pa140_c": 1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "AGPAT140", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT141"]}, "metabolites": {"tdeACP_c": -1.0, "pa141_c": 1.0, "ACP_c": 1.0, "1tdec7eg3p_c": -1.0}, "id": "AGPAT141", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT160"]}, "metabolites": {"pa160_c": 1.0, "ACP_c": 1.0, "1hdecg3p_c": -1.0, "palmACP_c": -1.0}, "id": "AGPAT160", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT161"]}, "metabolites": {"pa161_c": 1.0, "1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "YPO0672"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "YPO3927"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"rhcys_c": 1.0, "h2o_c": -1.0, "ahcys_c": -1.0, "ade_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "YPO3384"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "thf_c": 1.0, "10fthf_c": -1.0}, "id": "AICART", "gene_reaction_rule": "YPO3728"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "YPO3077"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "YPO3076"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "YPO3417 and YPO1113 and YPO1114"}, {"subsystem": "Transport; Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "YPO4003 and YPO4002 and YPO4001 and YPO4000 and YPO3999"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "YPO0557"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": "YPO0321"}, {"subsystem": "Transport; Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp", "gene_reaction_rule": "YPO3854"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"pydx5p_c": -1.0, "pyr_c": 1.0, "ala__D_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "YPO1357 or YPO2907"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_L2"]}, "metabolites": {"ala__L_c": -1.0, "pyr_c": 1.0, "pydx5p_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_L2", "gene_reaction_rule": "YPO2907 or YPO1357"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "tRNA Charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "YPO3305"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"glyald_c": -1.0, "nadh_c": -1.0, "glyc_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "ALCD19", "gene_reaction_rule": "YPO1502"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "etoh_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "ALCD2x", "gene_reaction_rule": "YPO1502 or YPO2180"}, {"subsystem": "Transport; Inner Membrane", "name": "D-allose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "all__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "all__D_c": 1.0}, "id": "ALLabcpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose 6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLPI"]}, "metabolites": {"all6p_c": -1.0, "allul6p_c": 1.0}, "id": "ALLPI", "gene_reaction_rule": "YPO3353"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allantoate amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTAMH"]}, "metabolites": {"alltt_c": -1.0, "urdglyc_c": 1.0, "h2o_c": -2.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "ALLTAMH", "gene_reaction_rule": "YPO3249"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Allose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLtex"]}, "metabolites": {"all__D_p": 1.0, "all__D_e": -1.0}, "id": "ALLtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Inner Membrane", "name": "Allantoin transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "alltn_c": 1.0, "alltn_p": -1.0}, "id": "ALLTNt2rpp", "gene_reaction_rule": "YPO1083"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Allantoin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNtex"]}, "metabolites": {"alltn_e": -1.0, "alltn_p": 1.0}, "id": "ALLTNtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylethanolamine, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATE160pp"]}, "metabolites": {"alpp_p": -1.0, "lpp_p": 1.0, "2agpe160_p": 1.0, "pe160_p": -1.0}, "id": "ALPATE160pp", "gene_reaction_rule": "YPO2616 and YPO2394"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylglycerol, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATG160pp"]}, "metabolites": {"alpp_p": -1.0, "pg160_p": -1.0, "2agpg160_p": 1.0, "lpp_p": 1.0}, "id": "ALPATG160pp", "gene_reaction_rule": "YPO2616 and YPO2394"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aldose reductase (methylglyoxal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR2"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "acetol_c": 1.0, "h_c": -1.0, "mthgxl_c": -1.0}, "id": "ALR2", "gene_reaction_rule": "YPO0676 or YPO1075"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Altronate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALTRH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "altrn_c": -1.0}, "id": "ALTRH", "gene_reaction_rule": "YPO0581"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM3PA"]}, "metabolites": {"anhm_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": 1.0, "anhm3p_c": -1.0}, "id": "AM3PA", "gene_reaction_rule": "YPO3423"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PA"]}, "metabolites": {"anhm_c": 1.0, "LalaDgluMdapDala_c": 1.0, "anhm4p_c": -1.0, "h2o_c": -1.0}, "id": "AM4PA", "gene_reaction_rule": "YPO3423"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT1"]}, "metabolites": {"glc__D_c": 1.0, "malt_c": -1.0, "malttr_c": -1.0, "maltttr_c": 1.0}, "id": "AMALT1", "gene_reaction_rule": "YPO0126"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT2"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "malt_c": -1.0, "maltttr_c": -1.0}, "id": "AMALT2", "gene_reaction_rule": "YPO0126"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT3"]}, "metabolites": {"maltpt_c": -1.0, "glc__D_c": 1.0, "malt_c": -1.0, "malthx_c": 1.0}, "id": "AMALT3", "gene_reaction_rule": "YPO0126"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT4"]}, "metabolites": {"glc__D_c": 1.0, "malthp_c": 1.0, "malt_c": -1.0, "malthx_c": -1.0}, "id": "AMALT4", "gene_reaction_rule": "YPO0126"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmannosamine 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methyltransferase (menaquinone 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMMQLT8"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "2dmmql8_c": -1.0, "h_c": 1.0, "mql8_c": 1.0}, "id": "AMMQLT8", "gene_reaction_rule": "YPO3781"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-amino-2-methyl-5-phosphomethylpyrimidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPMS2"]}, "metabolites": {"h2o_c": -1.0, "for_c": 2.0, "4ampm_c": 1.0, "h_c": 3.0, "nad_c": -1.0, "air_c": -1.0, "nadh_c": 1.0}, "id": "AMPMS2", "gene_reaction_rule": "YPO3739"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "AMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPN"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "r5p_c": 1.0, "amp_c": -1.0}, "id": "AMPN", "gene_reaction_rule": "YPO2288"}, {"subsystem": "Cysteine Metabolism", "name": "Alanyl aminopeptidase (cys-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASECG"]}, "metabolites": {"cys__L_c": 1.0, "h2o_c": -1.0, "gly_c": 1.0, "cgly_c": -1.0}, "id": "AMPTASECG", "gene_reaction_rule": "YPO3230 or YPO3441 or YPO2889 or YPO1414"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminopeptidase (pro-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASEPG"]}, "metabolites": {"h2o_c": -1.0, "pro__L_c": 1.0, "gly_c": 1.0, "progly_c": -1.0}, "id": "AMPTASEPG", "gene_reaction_rule": "YPO3441 or YPO3230 or YPO1414 or YPO2889"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "AMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMPtex"]}, "metabolites": {"amp_e": -1.0, "amp_p": 1.0}, "id": "AMPtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "GlcNAc-anhMurNAc transport 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{"subsystem": "Nucleotide Salvage Pathway", "name": "DCTP deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCTPD"]}, "metabolites": {"dutp_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0, "dctp_c": -1.0}, "id": "DCTPD", "gene_reaction_rule": "YPO1525"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxycytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0, "duri_c": 1.0, "h_c": -1.0}, "id": "DCYTD", "gene_reaction_rule": "YPO1512"}, {"subsystem": "Transport; Inner Membrane", "name": "Deoxycytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTt2pp"]}, "metabolites": {"dcyt_c": 1.0, "dcyt_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DCYTt2pp", "gene_reaction_rule": "YPO2983"}, {"subsystem": "Transport; Outer Membrane", "name": "Deoxycytidine transport 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"FDMO6", "gene_reaction_rule": "YPO3625"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Iron (II) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FE2abcpp"]}, "metabolites": {"h2o_c": -1.0, "fe2_p": -1.0, "atp_c": -1.0, "fe2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "FE2abcpp", "gene_reaction_rule": "YPO0132"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Iron (II) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FE2t2pp"]}, "metabolites": {"fe2_c": 1.0, "fe2_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FE2t2pp", "gene_reaction_rule": "YPO2982"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Iron (Fe+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FE2t3pp"]}, "metabolites": {"fe2_c": -1.0, "fe2_p": 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"Glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD7"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "G3PD7", "gene_reaction_rule": "YPO3825 and YPO3824"}, {"subsystem": "Transport; Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pe_c": 1.0, "g3pe_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PEabcpp", "gene_reaction_rule": "YPO3795 and YPO3796 and YPO3793 and YPO3794"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Glycero-3-phosphoethanolamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PEtex"]}, "metabolites": {"g3pe_e": -1.0, "g3pe_p": 1.0}, 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"gene_reaction_rule": "YPO2859 or YPO2368"}, {"subsystem": "Transport; Inner Membrane", "name": "L-homoserineserine efflux via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HOMt2pp"]}, "metabolites": {"hom__L_c": -1.0, "hom__L_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HOMt2pp", "gene_reaction_rule": "YPO3831"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "L-homoserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HOMtex"]}, "metabolites": {"hom__L_p": 1.0, "hom__L_e": -1.0}, "id": "HOMtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "6-hydroxymethyl-dihydropterin pyrophosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPPK2"]}, "metabolites": {"6hmhptpp_c": 1.0, "6hmhpt_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HPPK2", 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{"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (menaquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L__LACD3"]}, "metabolites": {"lac__L_c": -1.0, "pyr_c": 1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "L_LACD3", "gene_reaction_rule": "YPO1569"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "L-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L__LACtex"]}, "metabolites": {"lac__L_e": -1.0, "lac__L_p": 1.0}, "id": "L_LACtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A disaccaride synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPADSS"]}, "metabolites": {"u23ga_c": -1.0, "udp_c": 1.0, "h_c": 1.0, "lipidAds_c": 1.0, "lipidX_c": -1.0}, "id": "LPADSS", "gene_reaction_rule": "YPO1057"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A120pp"]}, "metabolites": {"glyc3p_p": 1.0, "1ddecg3p_p": -1.0, "ddca_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A120pp", "gene_reaction_rule": "YPO3080"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A140pp"]}, "metabolites": {"h2o_p": -1.0, "1tdecg3p_p": -1.0, "ttdca_p": 1.0, "h_p": 1.0, "glyc3p_p": 1.0}, "id": "LPLIPAL1A140pp", "gene_reaction_rule": "YPO3080"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A141pp"]}, "metabolites": {"h2o_p": -1.0, 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"name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE181"]}, "metabolites": {"apg181_c": 1.0, "2agpe181_c": -1.0, "pg181_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE181", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG120"]}, "metabolites": {"g3pg_c": 1.0, "pg120_c": -1.0, "2agpg120_c": -1.0, "apg120_c": 1.0}, "id": "LPLIPAL2ATG120", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG140"]}, "metabolites": {"g3pg_c": 1.0, "2agpg140_c": -1.0, 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG161"]}, "metabolites": {"g3pg_c": 1.0, "apg161_c": 1.0, "pg161_c": -1.0, "2agpg161_c": -1.0}, "id": "LPLIPAL2ATG161", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG180"]}, "metabolites": {"g3pg_c": 1.0, "pg180_c": -1.0, "2agpg180_c": -1.0, "apg180_c": 1.0}, "id": "LPLIPAL2ATG180", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG181"]}, "metabolites": {"apg181_c": 1.0, "g3pg_c": 1.0, "pg181_c": -1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2ATG181", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E120"]}, "metabolites": {"ddca_c": 1.0, "2agpe120_c": -1.0, "h_c": 1.0, "h2o_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E120", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E140"]}, "metabolites": {"h2o_c": -1.0, "ttdca_c": 1.0, "2agpe140_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E140", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E141"]}, "metabolites": {"2agpe141_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2E141", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E160"]}, "metabolites": {"h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E160", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E161"]}, "metabolites": {"hdcea_c": 1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "2agpe161_c": -1.0}, "id": "LPLIPAL2E161", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E180"]}, "metabolites": {"2agpe180_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2E180", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpe181_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E181", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G120"]}, "metabolites": {"ddca_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "2agpg120_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G120", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G140"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg140_c": -1.0, "ttdca_c": 1.0}, "id": "LPLIPAL2G140", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G141"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "2agpg141_c": -1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2G141", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G160"]}, "metabolites": {"2agpg160_c": -1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0}, "id": "LPLIPAL2G160", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G161"]}, "metabolites": {"hdcea_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg161_c": -1.0}, "id": "LPLIPAL2G161", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G180"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg180_c": -1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2G180", "gene_reaction_rule": "YPO3830"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, 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1.0, "h_p": -1.0, "lyx__L_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "YPO0334"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannitol-1-phosphate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["M1PD"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "mnl1p_c": -1.0, "nad_c": -1.0, "f6p_c": 1.0}, "id": "M1PD", "gene_reaction_rule": "YPO4067"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-ACP decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MACPD"]}, "metabolites": {"acACP_c": 1.0, "co2_c": 1.0, "malACP_c": -1.0, "h_c": -1.0}, "id": "MACPD", "gene_reaction_rule": "YPO2757"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Malate decarboxylating oxidoreductase (decarboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDDH"]}, "metabolites": {"mal__D_c": -1.0, "nadh_c": 1.0, "co2_c": 1.0, "pyr_c": 1.0, "nad_c": -1.0}, "id": "MALDDH", "gene_reaction_rule": "YPO2496"}, {"subsystem": "Transport; Inner Membrane", "name": "D-Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDt2_2pp"]}, "metabolites": {"mal__D_p": -1.0, "mal__D_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALDt2_2pp", "gene_reaction_rule": "YPO3992"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "D-Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALDtex"]}, "metabolites": {"mal__D_p": 1.0, "mal__D_e": -1.0}, "id": "MALDtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Anaplerotic Reactions", "name": "Malate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALS"]}, "metabolites": {"h2o_c": -1.0, "mal__L_c": 1.0, "glx_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "coa_c": 1.0}, "id": "MALS", "gene_reaction_rule": "YPO3726"}, {"subsystem": "Transport; Inner Membrane", "name": "Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_2pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALt2_2pp", "gene_reaction_rule": "YPO3992"}, {"subsystem": "Transport; Inner Membrane", "name": "Malate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_3pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "MALt2_3pp", "gene_reaction_rule": "YPO0347"}, {"subsystem": "Transport; Inner Membrane", "name": "Maltose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "malt_c": 1.0, "pi_c": 1.0}, "id": "MALTabcpp", "gene_reaction_rule": "YPO3714 and YPO3715 and YPO3716 and YPO3712"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALtex"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_e": -1.0}, "id": "MALtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Inner Membrane", "name": "Maltohexaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXabcpp"]}, "metabolites": {"h2o_c": -1.0, "malthx_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, 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YPO0954"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "YPO0452 or YPO1025 or YPO2957 or YPO2438 or YPO0954"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "YPO0452 or YPO1025 or YPO2957 or YPO2438 or YPO0954"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "YPO0452 or YPO1025 or YPO2957 or YPO2438 or YPO0954"}, {"subsystem": "Transport; Inner Membrane", "name": "S-methylmethionine permease (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMETt2pp"]}, "metabolites": {"h_p": -1.0, "mmet_c": 1.0, "mmet_p": -1.0, "h_c": 1.0}, "id": "MMETt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "YPO1129"}, {"subsystem": "Transport; Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "YPO4068 and YPO2993"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "YPO1283"}, {"subsystem": "Transport; Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "YPO2982"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT"]}, "metabolites": {"kdolipid4_c": 1.0, "cmp_c": 1.0, "ckdo_c": -1.0, "h_c": 1.0, "lipidA_c": -1.0}, "id": "MOAT", "gene_reaction_rule": "YPO0055"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT2"]}, "metabolites": {"kdo2lipid4_c": 1.0, "ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "kdolipid4_c": -1.0}, "id": "MOAT2", "gene_reaction_rule": "YPO0055"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Molybdate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOBDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mobd_c": 1.0, "mobd_p": -1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "MOBDabcpp", "gene_reaction_rule": "(YPO1145 and YPO1146 and YPO1147) or (YPO3012 and YPO3014 and YPO3013 and YPO3015) or (YPO3012 and YPO3014 and YPO3013)"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Molybdate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOBDtex"]}, "metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"thf_c": 1.0, "h2o_c": -1.0, "2dhp_c": 1.0, "mlthf_c": -1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "YPO3401"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "YPO3393 or YPO0145"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"udcpdp_c": 1.0, "uaagmda_c": -1.0, "murein5p5p5p_p": 1.0, "h_c": 1.0, "murein5p5p_p": -1.0}, "id": "MPTG2", "gene_reaction_rule": "YPO3393 or YPO0145"}, {"subsystem": "Transport; Inner Membrane", "name": "Methanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mso3_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mso3_p": -1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "YPO3624 and YPO3627 and YPO3626"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"ade_c": 1.0, "5mta_c": -1.0, "5mtr_c": 1.0, "h2o_c": -1.0}, "id": "MTAN", "gene_reaction_rule": "YPO3384"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": 1.0, "h_c": 1.0, "methf_c": -1.0}, "id": "MTHFC", "gene_reaction_rule": "YPO2824"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "YPO2824"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"mlthf_c": -1.0, "nadh_c": -1.0, "5mthf_c": 1.0, "nad_c": 1.0, "h_c": -2.0}, "id": "MTHFR2", "gene_reaction_rule": "YPO0117"}, {"subsystem": "Glycine and Serine Metabolism", "name": "N-methyltryptophan oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRPOX"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "Nmtrp_c": -1.0, "fald_c": 1.0, "h2o2_c": 1.0, "trp__L_c": 1.0}, "id": "MTRPOX", "gene_reaction_rule": "YPO2448"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Nitrious oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otex"]}, "metabolites": {"n2o_p": 1.0, "n2o_e": -1.0}, "id": "N2Otex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrious oxide transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otpp"]}, "metabolites": {"n2o_c": 1.0, "n2o_p": -1.0}, "id": "N2Otpp", "gene_reaction_rule": ""}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "YPO3928"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "amp_c": 1.0, "nad_c": -1.0, "h_c": 2.0}, "id": "NADDP", "gene_reaction_rule": "YPO3736"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"mql8_c": 1.0, "nadh_c": -1.0, "mqn8_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "NADH10", "gene_reaction_rule": "YPO1617"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0}, "id": "NADH16pp", "gene_reaction_rule": "YPO2543 and YPO2544 and YPO2545 and YPO2546 and YPO2547 and YPO2548 and YPO2549 and YPO2550 and YPO2551 and YPO2552 and YPO2553 and YPO2554 and YPO2555"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "YPO2543 and YPO2544 and YPO2545 and YPO2546 and YPO2547 and YPO2548 and YPO2549 and YPO2550 and YPO2551 and YPO2552 and YPO2553 and YPO2554 and YPO2555"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": "YPO2543 and YPO2544 and YPO2545 and YPO2546 and YPO2547 and YPO2548 and YPO2549 and YPO2550 and YPO2551 and YPO2552 and YPO2553 and YPO2554 and YPO2555"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 )", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH5"]}, "metabolites": {"q8h2_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH5", "gene_reaction_rule": "YPO1617"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH9"]}, "metabolites": {"nadh_c": -1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH9", "gene_reaction_rule": "YPO1617"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"adp_c": 1.0, "nadp_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "atp_c": -1.0}, "id": "NADK", "gene_reaction_rule": "YPO1106"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "q8_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "YPO0670"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"mqn8_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "YPO0670"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "YPO0670"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "YPO3914 or (YPO2302 and YPO2303)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, "ppi_c": 1.0, "nac_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "prpp_c": -1.0}, "id": "NAMNPP", "gene_reaction_rule": "YPO1413"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 1.5) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_1p5pp"]}, "metabolites": {"na1_p": 2.0, "na1_c": -2.0, "h_c": 3.0, "h_p": -3.0}, "id": "NAt3_1p5pp", "gene_reaction_rule": "YPO2142"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 2) (periplasm)", "upper_bound": 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"Tetradecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TTDCEAtexi"]}, "metabolites": {"ttdcea_e": -1.0, "ttdcea_p": 1.0}, "id": "TTDCEAtexi", "gene_reaction_rule": "YPO2744"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Tungstate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TUNGSabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "tungs_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "tungs_p": -1.0}, "id": "TUNGSabcpp", "gene_reaction_rule": "YPO1145 and YPO1146 and YPO1147"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Tungstate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TUNGStex"]}, "metabolites": {"tungs_e": -1.0, "tungs_p": 1.0}, "id": "TUNGStex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Tyramine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYMtex"]}, "metabolites": {"tym_e": -1.0, "tym_p": 1.0}, "id": "TYMtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "Phopho-L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRPtex"]}, "metabolites": {"tyrp_p": 1.0, "tyrp_e": -1.0}, "id": "TYRPtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "Transport; Inner Membrane", "name": "L-tyrosine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRt2rpp"]}, "metabolites": {"tyr__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "tyr__L_c": 1.0}, "id": "TYRt2rpp", "gene_reaction_rule": "YPO1209"}, {"subsystem": "Tyrosine; Tryptophan; and Phenylalanine Metabolism", "name": "Tyrosine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRTA"]}, "metabolites": {"akg_c": -1.0, "34hpp_c": 1.0, "glu__L_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTA", "gene_reaction_rule": "YPO0322 or YPO1410"}, {"subsystem": "Transport; Outer Membrane Porin", "name": "L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRtex"]}, "metabolites": {"tyr__L_e": -1.0, "tyr__L_p": 1.0}, "id": "TYRtex", "gene_reaction_rule": "YPO1222"}, {"subsystem": "tRNA charging", "name": "Tyrosyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "tyrtrna_c": 1.0, "trnatyr_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTRS", "gene_reaction_rule": "YPO2369"}, {"subsystem": "Lipopolysaccharide 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"gene_reaction_rule": "YPO1600 and YPO1056"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGCVT"]}, "metabolites": {"pep_c": -1.0, "uacgam_c": -1.0, "uaccg_c": 1.0, "pi_c": 1.0}, "id": "UAGCVT", "gene_reaction_rule": "YPO3569"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGDP"]}, "metabolites": {"uacgam_c": 1.0, "utp_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "acgam1p_c": -1.0}, "id": "UAGDP", "gene_reaction_rule": "YPO4119"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGPT3"]}, "metabolites": {"uacgam_c": -1.0, "uaagmda_c": 1.0, 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"metabolites": {"uamr_c": 1.0, "uaccg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "UAPGR", "gene_reaction_rule": "YPO3760"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Undecaprenyl-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDP"]}, "metabolites": {"udcpdp_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "udcpp_c": 1.0}, "id": "UDCPDP", "gene_reaction_rule": "YPO1324 or YPO2223"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Undecaprenyl-diphosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "udcpdp_p": -1.0, "udcpp_p": 1.0, "h_p": 1.0}, "id": "UDCPDPpp", "gene_reaction_rule": "YPO2223 or YPO1324"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Undecaprenyl diphosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDPS"]}, 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{"name": "Sn-Glycero-3-phosphocholine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_g3pc_e"]}, "metabolites": {"g3pc_e": -1.0}, "id": "EX_g3pc_e", "gene_reaction_rule": ""}, {"name": "Sn-Glycero-3-phosphoethanolamine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_g3pe_e"]}, "metabolites": {"g3pe_e": -1.0}, "id": "EX_g3pe_e", "gene_reaction_rule": ""}, {"name": "Glycerophosphoglycerol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_g3pg_e"]}, "metabolites": {"g3pg_e": -1.0}, "id": "EX_g3pg_e", "gene_reaction_rule": ""}, {"name": "Sn-Glycero-3-phospho-1-inositol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_g3pi_e"]}, "metabolites": {"g3pi_e": -1.0}, "id": "EX_g3pi_e", "gene_reaction_rule": ""}, {"name": "Glycerophosphoserine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": 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"GMP exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_gmp_e"]}, "metabolites": {"gmp_e": -1.0}, "id": "EX_gmp_e", "gene_reaction_rule": ""}, {"name": "Guanosine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_gsn_e"]}, "metabolites": {"gsn_e": -1.0}, "id": "EX_gsn_e", "gene_reaction_rule": ""}, {"name": "Oxidized glutathione exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_gthox_e"]}, "metabolites": {"gthox_e": -1.0}, "id": "EX_gthox_e", "gene_reaction_rule": ""}, {"name": "Reduced glutathione exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_gthrd_e"]}, "metabolites": {"gthrd_e": -1.0}, "id": "EX_gthrd_e", "gene_reaction_rule": ""}, {"name": "GTP exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_gtp_e"]}, "metabolites": {"gtp_e": -1.0}, "id": "EX_gtp_e", "gene_reaction_rule": ""}, {"name": "Hydrogen peroxide exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_h2o2_e"]}, "metabolites": {"h2o2_e": -1.0}, "id": "EX_h2o2_e", "gene_reaction_rule": ""}, {"name": "H2O exchange", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["EX_h2o_e"]}, "metabolites": {"h2o_e": -1.0}, "id": "EX_h2o_e", "gene_reaction_rule": ""}, {"name": "Hydrogen sulfide exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_h2s_e"]}, "metabolites": {"h2s_e": -1.0}, "id": "EX_h2s_e", "gene_reaction_rule": ""}, {"name": "H2 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_h2_e"]}, "metabolites": {"h2_e": -1.0}, "id": "EX_h2_e", "gene_reaction_rule": ""}, {"name": "3-hydroxycinnamic acid exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_3hcinnm_e"]}, "metabolites": {"3hcinnm_e": -1.0}, "id": "EX_3hcinnm_e", 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"gene_reaction_rule": ""}, {"name": "2(alpha-D-Mannosyl)-D-glycerate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_manglyc_e"]}, "metabolites": {"manglyc_e": -1.0}, "id": "EX_manglyc_e", "gene_reaction_rule": ""}, {"name": "D-Mannose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_man_e"]}, "metabolites": {"man_e": -1.0}, "id": "EX_man_e", "gene_reaction_rule": ""}, {"name": "Melibiose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_melib_e"]}, "metabolites": {"melib_e": -1.0}, "id": "EX_melib_e", "gene_reaction_rule": ""}, {"name": "D-Methionine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_met__D_e"]}, "metabolites": {"met__D_e": -1.0}, "id": "EX_met__D_e", "gene_reaction_rule": ""}, {"name": "L-Methionine S-oxide exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": 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"S-Methyl-L-methionine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_mmet_e"]}, "metabolites": {"mmet_e": -1.0}, "id": "EX_mmet_e", "gene_reaction_rule": ""}, {"name": "D-Mannitol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_mnl_e"]}, "metabolites": {"mnl_e": -1.0}, "id": "EX_mnl_e", "gene_reaction_rule": ""}, {"name": "Mn2+ exchange", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["EX_mn2_e"]}, "metabolites": {"mn2_e": -1.0}, "id": "EX_mn2_e", "gene_reaction_rule": ""}, {"name": "Molybdate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_mobd_e"]}, "metabolites": {"mobd_e": -1.0}, "id": "EX_mobd_e", "gene_reaction_rule": ""}, {"name": "Methanesulfonate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_mso3_e"]}, "metabolites": {"mso3_e": -1.0}, "id": "EX_mso3_e", "gene_reaction_rule": 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{"notes": {"original_bigg_ids": ["YPO3727"]}, "name": "metA", "id": "YPO3727"}, {"notes": {"original_bigg_ids": ["YPO1547"]}, "name": "hisC", "id": "YPO1547"}, {"notes": {"original_bigg_ids": ["YPO1641"]}, "name": "icdA", "id": "YPO1641"}, {"notes": {"original_bigg_ids": ["YPO2528"]}, "name": "menF", "id": "YPO2528"}, {"notes": {"original_bigg_ids": ["YPO3725"]}, "name": "aceA", "id": "YPO3725"}, {"notes": {"original_bigg_ids": ["YPO1545"]}, "name": "hisH", "id": "YPO1545"}, {"notes": {"original_bigg_ids": ["YPO1543"]}, "name": "hisF", "id": "YPO1543"}, {"notes": {"original_bigg_ids": ["YPO2205"]}, "name": "trpC", "id": "YPO2205"}, {"notes": {"original_bigg_ids": ["YPO3808"]}, "name": "livJ", "id": "YPO3808"}, {"notes": {"original_bigg_ids": ["YPO3804"]}, "name": "livF", "id": "YPO3804"}, {"notes": {"original_bigg_ids": ["YPO3807"]}, "name": "livH", "id": "YPO3807"}, {"notes": {"original_bigg_ids": ["YPO3805"]}, "name": "livG", "id": "YPO3805"}, {"notes": {"original_bigg_ids": 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"YPO2691"}, {"notes": {"original_bigg_ids": ["YPO3767"]}, "name": "fadA", "id": "YPO3767"}, {"notes": {"original_bigg_ids": ["YPO1400"]}, "name": "kdsB", "id": "YPO1400"}, {"notes": {"original_bigg_ids": ["YPO3578"]}, "name": "None", "id": "YPO3578"}, {"notes": {"original_bigg_ids": ["YPO2021"]}, "name": "kdsA", "id": "YPO2021"}, {"notes": {"original_bigg_ids": ["YPO2675"]}, "name": "None", "id": "YPO2675"}, {"notes": {"original_bigg_ids": ["YPO0006"]}, "name": "trkD", "id": "YPO0006"}, {"notes": {"original_bigg_ids": ["YPO3762"]}, "name": "trkH", "id": "YPO3762"}, {"notes": {"original_bigg_ids": ["YPO0239"]}, "name": "trkA", "id": "YPO0239"}, {"notes": {"original_bigg_ids": ["YPO4048"]}, "name": "cmr", "id": "YPO4048"}, {"notes": {"original_bigg_ids": ["YPO3094"]}, "name": "rosB", "id": "YPO3094"}, {"notes": {"original_bigg_ids": ["YPO2418"]}, "name": "arnT", "id": "YPO2418"}, {"notes": {"original_bigg_ids": ["YPO0616"]}, "name": "None", "id": "YPO0616"}, {"notes": {"original_bigg_ids": ["YPO1177"]}, "name": "dld", "id": "YPO1177"}, {"notes": {"original_bigg_ids": ["YPO2329"]}, "name": "hslI", "id": "YPO2329"}, {"notes": {"original_bigg_ids": ["YPO0322"]}, "name": "tyrB", "id": "YPO0322"}, {"notes": {"original_bigg_ids": ["YPO2610"]}, "name": "leuS", "id": "YPO2610"}, {"notes": {"original_bigg_ids": ["YPO2381"]}, "name": "gloA", "id": "YPO2381"}, {"notes": {"original_bigg_ids": ["YPO1569"]}, "name": "lldD", "id": "YPO1569"}, {"notes": {"original_bigg_ids": ["YPO1057"]}, "name": "lpxB", "id": "YPO1057"}, {"notes": {"original_bigg_ids": ["YPO3080"]}, "name": "tesA", "id": "YPO3080"}, {"notes": {"original_bigg_ids": ["YPO3830"]}, "name": "pldB", "id": "YPO3830"}, {"notes": {"original_bigg_ids": ["YPO0888"]}, "name": "lysS", "id": "YPO0888"}, {"notes": {"original_bigg_ids": ["YPO0329"]}, "name": "rhaA", "id": "YPO0329"}, {"notes": {"original_bigg_ids": ["YPO0334"]}, "name": "rhaT", "id": "YPO0334"}, {"notes": {"original_bigg_ids": ["YPO4067"]}, 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{"notes": {"original_bigg_ids": ["YPO1176"]}, "name": "pbpG", "id": "YPO1176"}, {"notes": {"original_bigg_ids": ["YPO2752"]}, "name": "mepA", "id": "YPO2752"}, {"notes": {"original_bigg_ids": ["YPO3516"]}, "name": "mdh", "id": "YPO3516"}, {"notes": {"original_bigg_ids": ["YPO1511"]}, "name": "sfcA", "id": "YPO1511"}, {"notes": {"original_bigg_ids": ["YPO3034"]}, "name": "maeB", "id": "YPO3034"}, {"notes": {"original_bigg_ids": ["YPO2879"]}, "name": "ispG", "id": "YPO2879"}, {"notes": {"original_bigg_ids": ["YPO3360"]}, "name": "ispF", "id": "YPO3360"}, {"notes": {"original_bigg_ids": ["YPO0995"]}, "name": "None", "id": "YPO0995"}, {"notes": {"original_bigg_ids": ["YPO3361"]}, "name": "ispD", "id": "YPO3361"}, {"notes": {"original_bigg_ids": ["YPO1073"]}, "name": "metN", "id": "YPO1073"}, {"notes": {"original_bigg_ids": ["YPO1072"]}, "name": "None", "id": "YPO1072"}, {"notes": {"original_bigg_ids": ["YPO0931"]}, "name": "metK", "id": "YPO0931"}, {"notes": {"original_bigg_ids": 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"YPO0452"}, {"notes": {"original_bigg_ids": ["YPO0954"]}, "name": "mltC", "id": "YPO0954"}, {"notes": {"original_bigg_ids": ["YPO4068"]}, "name": "mtlA", "id": "YPO4068"}, {"notes": {"original_bigg_ids": ["YPO1283"]}, "name": "uxuA", "id": "YPO1283"}, {"notes": {"original_bigg_ids": ["YPO0055"]}, "name": "kdtA", "id": "YPO0055"}, {"notes": {"original_bigg_ids": ["YPO3015"]}, "name": "cysP", "id": "YPO3015"}, {"notes": {"original_bigg_ids": ["YPO1145"]}, "name": "modA", "id": "YPO1145"}, {"notes": {"original_bigg_ids": ["YPO3013"]}, "name": "cysW", "id": "YPO3013"}, {"notes": {"original_bigg_ids": ["YPO1146"]}, "name": "modB", "id": "YPO1146"}, {"notes": {"original_bigg_ids": ["YPO3014"]}, "name": "cysT", "id": "YPO3014"}, {"notes": {"original_bigg_ids": ["YPO1147"]}, "name": "modC", "id": "YPO1147"}, {"notes": {"original_bigg_ids": ["YPO3012"]}, "name": "cysA", "id": "YPO3012"}, {"notes": {"original_bigg_ids": ["YPO3401"]}, "name": "panB", "id": "YPO3401"}, {"notes": {"original_bigg_ids": ["YPO2824"]}, "name": "folD", "id": "YPO2824"}, {"notes": {"original_bigg_ids": ["YPO0117"]}, "name": "metF", "id": "YPO0117"}, {"notes": {"original_bigg_ids": ["YPO2448"]}, "name": "solA", "id": "YPO2448"}, {"notes": {"original_bigg_ids": ["YPO3736"]}, "name": "nudC", "id": "YPO3736"}, {"notes": {"original_bigg_ids": ["YPO1617"]}, "name": "ndh", "id": "YPO1617"}, {"notes": {"original_bigg_ids": ["YPO2548"]}, "name": "nuoI", "id": "YPO2548"}, {"notes": {"original_bigg_ids": ["YPO2550"]}, "name": "nuoG", "id": "YPO2550"}, {"notes": {"original_bigg_ids": ["YPO2555"]}, "name": "nuoA", "id": "YPO2555"}, {"notes": {"original_bigg_ids": ["YPO2547"]}, "name": "nuoJ", "id": "YPO2547"}, {"notes": {"original_bigg_ids": ["YPO2552"]}, "name": "nuoE", "id": "YPO2552"}, {"notes": {"original_bigg_ids": ["YPO2553"]}, "name": "nuoD", "id": "YPO2553"}, {"notes": {"original_bigg_ids": ["YPO2554"]}, "name": "nuoB", "id": "YPO2554"}, {"notes": {"original_bigg_ids": ["YPO2544"]}, 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{"notes": {"original_bigg_ids": ["YPO0470"]}, "name": "nhaA", "id": "YPO0470"}, {"notes": {"original_bigg_ids": ["YPO2883"]}, "name": "ndk", "id": "YPO2883"}, {"notes": {"original_bigg_ids": ["YPO3142"]}, "name": "amtB", "id": "YPO3142"}, {"notes": {"original_bigg_ids": ["YPO0444"]}, "name": "nadR", "id": "YPO0444"}, {"notes": {"original_bigg_ids": ["YPO2607"]}, "name": "nadD", "id": "YPO2607"}, {"notes": {"original_bigg_ids": ["YPO1128"]}, "name": "pnuC", "id": "YPO1128"}, {"notes": {"original_bigg_ids": ["YPO2160"]}, "name": "pncA", "id": "YPO2160"}, {"notes": {"original_bigg_ids": ["YPO3424"]}, "name": "nadC", "id": "YPO3424"}, {"notes": {"original_bigg_ids": ["YPO0159"]}, "name": "nirC", "id": "YPO0159"}, {"notes": {"original_bigg_ids": ["YPO3037"]}, "name": "napB", "id": "YPO3037"}, {"notes": {"original_bigg_ids": ["YPO3038"]}, "name": "napA", "id": "YPO3038"}, {"notes": {"original_bigg_ids": ["YPO3036"]}, "name": "napC", "id": "YPO3036"}, {"notes": {"original_bigg_ids": 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"YPO0161"}, {"notes": {"original_bigg_ids": ["YPO2705"]}, "name": "None", "id": "YPO2705"}, {"notes": {"original_bigg_ids": ["YPO3446"]}, "name": "argI", "id": "YPO3446"}, {"notes": {"original_bigg_ids": ["YPO3513"]}, "name": "ispB", "id": "YPO3513"}, {"notes": {"original_bigg_ids": ["YPO1389"]}, "name": "serC", "id": "YPO1389"}, {"notes": {"original_bigg_ids": ["YPO2621"]}, "name": "ubiF", "id": "YPO2621"}, {"notes": {"original_bigg_ids": ["YPO2227"]}, "name": "pyrF", "id": "YPO2227"}, {"notes": {"original_bigg_ids": ["YPO0909"]}, "name": "ubiH", "id": "YPO0909"}, {"notes": {"original_bigg_ids": ["YPO1766"]}, "name": "hpaH", "id": "YPO1766"}, {"notes": {"original_bigg_ids": ["YPO3769"]}, "name": "None", "id": "YPO3769"}, {"notes": {"original_bigg_ids": ["YPO2773"]}, "name": "ubiX", "id": "YPO2773"}, {"notes": {"original_bigg_ids": ["YPO3779"]}, "name": "ubiB", "id": "YPO3779"}, {"notes": {"original_bigg_ids": ["YPO0960"]}, "name": "speC", "id": "YPO0960"}, {"notes": {"original_bigg_ids": ["YPO0045"]}, "name": "pyrE", "id": "YPO0045"}, {"notes": {"original_bigg_ids": ["YPO2527"]}, "name": "menD", "id": "YPO2527"}, {"notes": {"original_bigg_ids": ["YPO1851"]}, "name": "putA", "id": "YPO1851"}, {"notes": {"original_bigg_ids": ["YPO0942"]}, "name": "proC", "id": "YPO0942"}, {"notes": {"original_bigg_ids": ["YPO3402"]}, "name": "panC", "id": "YPO3402"}, {"notes": {"original_bigg_ids": ["YPO2223"]}, "name": "pgpB", "id": "YPO2223"}, {"notes": {"original_bigg_ids": ["YPO0552"]}, "name": "mraY", "id": "YPO0552"}, {"notes": {"original_bigg_ids": ["YPO3419"]}, "name": "aceE", "id": "YPO3419"}, {"notes": {"original_bigg_ids": ["YPO3418"]}, "name": "aceF", "id": "YPO3418"}, {"notes": {"original_bigg_ids": ["YPO2370"]}, "name": "pdxH", "id": "YPO2370"}, {"notes": {"original_bigg_ids": ["YPO0493"]}, "name": "pdxA", "id": "YPO0493"}, {"notes": {"original_bigg_ids": ["YPO2930"]}, "name": "pdxJ", "id": "YPO2930"}, {"notes": {"original_bigg_ids": ["YPO2763"]}, "name": "pdxB", "id": "YPO2763"}, {"notes": {"original_bigg_ids": ["YPO0078"]}, "name": "pfkA", "id": "YPO0078"}, {"notes": {"original_bigg_ids": ["YPO1383"]}, "name": "pfl", "id": "YPO1383"}, {"notes": {"original_bigg_ids": ["YPO1381"]}, "name": "pflA", "id": "YPO1381"}, {"notes": {"original_bigg_ids": ["YPO3500"]}, "name": "glmM", "id": "YPO3500"}, {"notes": {"original_bigg_ids": ["YPO0914"]}, "name": "serA", "id": "YPO0914"}, {"notes": {"original_bigg_ids": ["YPO3718"]}, "name": "pgi", "id": "YPO3718"}, {"notes": {"original_bigg_ids": ["YPO0921"]}, "name": "pgk", "id": "YPO0921"}, {"notes": {"original_bigg_ids": ["YPO1149"]}, "name": "None", "id": "YPO1149"}, {"notes": {"original_bigg_ids": ["YPO0156"]}, "name": "gph", "id": "YPO0156"}, {"notes": {"original_bigg_ids": ["YPO1133"]}, "name": "gpmA", "id": "YPO1133"}, {"notes": {"original_bigg_ids": ["YPO2686"]}, "name": "pgm", "id": "YPO2686"}, {"notes": {"original_bigg_ids": ["YPO3179"]}, "name": "pgpA", "id": "YPO3179"}, {"notes": {"original_bigg_ids": ["YPO1867"]}, "name": "pgsA", "id": "YPO1867"}, {"notes": {"original_bigg_ids": ["YPO2736"]}, "name": "ccmC", "id": "YPO2736"}, {"notes": {"original_bigg_ids": ["YPO2735"]}, "name": "ccmB", "id": "YPO2735"}, {"notes": {"original_bigg_ids": ["YPO2734"]}, "name": "ccmA", "id": "YPO2734"}, {"notes": {"original_bigg_ids": ["YPO2429"]}, "name": "pheS", "id": "YPO2429"}, {"notes": {"original_bigg_ids": ["YPO2428"]}, "name": "pheT", "id": "YPO2428"}, {"notes": {"original_bigg_ids": ["YPO3967"]}, "name": "None", "id": "YPO3967"}, {"notes": {"original_bigg_ids": ["YPO4114"]}, "name": "pstB", "id": "YPO4114"}, {"notes": {"original_bigg_ids": ["YPO4117"]}, "name": "pstS", "id": "YPO4117"}, {"notes": {"original_bigg_ids": ["YPO4115"]}, "name": "pstA", "id": "YPO4115"}, {"notes": {"original_bigg_ids": ["YPO4116"]}, "name": "pstC", "id": "YPO4116"}, {"notes": {"original_bigg_ids": ["YPO3834"]}, "name": "pldA", "id": "YPO3834"}, {"notes": {"original_bigg_ids": ["YPO3097"]}, 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"C33H54N7O17P3S", "compartment": "c", "id": "ddcacoa_c"}, {"name": "1-tetradecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["1tdecg3p_p"]}, "charge": -2, "formula": "C17H33O7P1", "compartment": "p", "id": "1tdecg3p_p"}, {"name": "Two linked disacharide pentapeptide and tetrapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p4p_p"]}, "charge": -4, "formula": "C77H119N15O41", "compartment": "p", "id": "murein5p4p_p"}, {"name": "TRNA(Arg)", "notes": {"original_bigg_ids": ["trnaarg_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnaarg_c"}, {"name": "4-Phospho-L-aspartate", "notes": {"original_bigg_ids": ["4pasp_c"]}, "charge": -2, "formula": "C4H6NO7P", "compartment": "c", "id": "4pasp_c"}, {"name": "Coproporphyrinogen III", "notes": {"original_bigg_ids": ["cpppg3_c"]}, "charge": -4, "formula": "C36H40N4O8", "compartment": "c", "id": "cpppg3_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_c"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "c", "id": "LalaDgluMdapDala_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_e"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "e", "id": "LalaDgluMdapDala_e"}, {"name": "Cytosine", "notes": {"original_bigg_ids": ["csn_p"]}, "charge": 0, "formula": "C4H5N3O", "compartment": "p", "id": "csn_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_p"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "p", "id": "LalaDgluMdapDala_p"}, {"name": "D-Glucosamine 1-phosphate", "notes": {"original_bigg_ids": ["gam1p_c"]}, "charge": -1, "formula": "C6H13NO8P", "compartment": "c", "id": "gam1p_c"}, {"name": "Cytosine", "notes": {"original_bigg_ids": 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{"name": "2,5-Diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate", "notes": {"original_bigg_ids": ["25drapp_c"]}, "charge": -2, "formula": "C9H14N5O8P", "compartment": "c", "id": "25drapp_c"}, {"name": "Alpha-D-Galactose 1-phosphate", "notes": {"original_bigg_ids": ["gal1p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "gal1p_c"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_c"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "c", "id": "ump_c"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["1agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "1agpg160_p"}, {"name": "Propanoyl phosphate", "notes": {"original_bigg_ids": ["ppap_c"]}, "charge": -2, "formula": "C3H5O5P", "compartment": "c", "id": "ppap_c"}, {"name": "TRNA(Gly)", "notes": {"original_bigg_ids": ["trnagly_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnagly_c"}, {"name": "Xanthine", "notes": 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(dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pe181_c"]}, "charge": 0, "formula": "C41H78N1O8P1", "compartment": "c", "id": "pe181_c"}, {"name": "5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide", "notes": {"original_bigg_ids": ["prlp_c"]}, "charge": -4, "formula": "C15H21N5O15P2", "compartment": "c", "id": "prlp_c"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_p"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "p", "id": "nac_p"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_p"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "p", "id": "pgp181_p"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "malttr_p"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_c"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "c", "id": "pgp181_c"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "malttr_e"}, {"name": "Fused thiol:disulfide interchange protein (reduced)", "notes": {"original_bigg_ids": ["dsbdrd_c"]}, "charge": 0, "formula": "XH2", "compartment": "c", "id": "dsbdrd_c"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_c"]}, "charge": 0, "formula": "C18H32O16", "compartment": "c", "id": "malttr_c"}, {"name": "1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["12dgr180_p"]}, "charge": 0, "formula": "C39H76O5", "compartment": "p", "id": "12dgr180_p"}, {"name": "D-Glycerate 2-phosphate", "notes": {"original_bigg_ids": ["2pg_c"]}, "charge": -3, "formula": "C3H4O7P", "compartment": "c", "id": "2pg_c"}, {"name": "(S)-3-Hydroxyhexanoyl-CoA", "notes": {"original_bigg_ids": ["3hhcoa_c"]}, "charge": -4, "formula": "C27H42N7O18P3S", "compartment": "c", "id": "3hhcoa_c"}, {"name": "Tetradecenoate (n-C14:1)", "notes": {"original_bigg_ids": ["ttdcea_p"]}, "charge": -1, "formula": "C14H25O2", "compartment": "p", "id": "ttdcea_p"}, {"name": "Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["uagmda_c"]}, "charge": -4, "formula": "C87H139N7O23P2", "compartment": "c", "id": "uagmda_c"}, {"name": "1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["12dgr180_c"]}, "charge": 0, "formula": "C39H76O5", "compartment": "c", "id": "12dgr180_c"}, {"name": "Glycogen", "notes": {"original_bigg_ids": ["glycogen_c"]}, "charge": 0, "formula": "C6H10O5", "compartment": "c", "id": "glycogen_c"}, {"name": "Tetradecenoate (n-C14:1)", "notes": {"original_bigg_ids": ["ttdcea_e"]}, "charge": -1, "formula": "C14H25O2", "compartment": "e", "id": "ttdcea_e"}, {"name": "Tetradecenoate (n-C14:1)", "notes": 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"C5H10NO2S", "compartment": "e", "id": "met__D_e"}, {"name": "Decanoate (n-C10:0)", "notes": {"original_bigg_ids": ["dca_p"]}, "charge": -1, "formula": "C10H19O2", "compartment": "p", "id": "dca_p"}, {"name": "3-Oxooctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctACP_c"]}, "charge": -1, "formula": "C19H33N2O9PRS", "compartment": "c", "id": "3ooctACP_c"}, {"name": "D-Sorbitol 6-phosphate", "notes": {"original_bigg_ids": ["sbt6p_c"]}, "charge": -2, "formula": "C6H13O9P", "compartment": "c", "id": "sbt6p_c"}, {"name": "Decanoate (n-C10:0)", "notes": {"original_bigg_ids": ["dca_e"]}, "charge": -1, "formula": "C10H19O2", "compartment": "e", "id": "dca_e"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met__D_p"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "p", "id": "met__D_p"}, {"name": "Acyl phosphatidylglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["apg140_c"]}, "charge": -1, "formula": "C48H92O11P", "compartment": "c", "id": "apg140_c"}, {"name": "Riboflavin", "notes": {"original_bigg_ids": ["ribflv_c"]}, "charge": 0, "formula": "C17H20N4O6", "compartment": "c", "id": "ribflv_c"}, {"name": "Reduced riboflavin", "notes": {"original_bigg_ids": ["rbflvrd_c"]}, "charge": 0, "formula": "C17H22N4O6", "compartment": "c", "id": "rbflvrd_c"}, {"name": "Gamma-butyrobetaine", "notes": {"original_bigg_ids": ["gbbtn_e"]}, "charge": 0, "formula": "C7H15NO2", "compartment": "e", "id": "gbbtn_e"}, {"name": "Trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c9palmeACP_c"]}, "charge": -1, "formula": "C27H47N2O8PRS", "compartment": "c", "id": "t3c9palmeACP_c"}, {"name": "Fe-enterobactin", "notes": {"original_bigg_ids": ["feenter_p"]}, "charge": 3, "formula": "C30H27FeN3O15", "compartment": "p", "id": "feenter_p"}, {"name": "Fe-enterobactin", "notes": {"original_bigg_ids": ["feenter_e"]}, "charge": 3, "formula": "C30H27FeN3O15", "compartment": "e", "id": "feenter_e"}, {"name": "Fe-enterobactin", "notes": {"original_bigg_ids": ["feenter_c"]}, "charge": 3, "formula": "C30H27FeN3O15", "compartment": "c", "id": "feenter_c"}, {"name": "Gamma-butyrobetaine", "notes": {"original_bigg_ids": ["gbbtn_p"]}, "charge": 0, "formula": "C7H15NO2", "compartment": "p", "id": "gbbtn_p"}, {"name": "(S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate", "notes": {"original_bigg_ids": ["25aics_c"]}, "charge": -4, "formula": "C13H15N4O12P", "compartment": "c", "id": "25aics_c"}, {"name": "UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine", "notes": {"original_bigg_ids": ["uaccg_c"]}, "charge": -3, "formula": "C20H26N3O19P2", "compartment": "c", "id": "uaccg_c"}, {"name": "Hydrogen sulfide", "notes": {"original_bigg_ids": ["h2s_e"]}, "charge": 0, "formula": "H2S", "compartment": "e", "id": "h2s_e"}, {"name": "Hydrogen sulfide", "notes": {"original_bigg_ids": ["h2s_c"]}, "charge": 0, "formula": "H2S", "compartment": "c", "id": "h2s_c"}, {"name": "L-Ribulose 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"2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_p"]}, "charge": -1, "formula": "C9H15O9", "compartment": "p", "id": "manglyc_p"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_p"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "p", "id": "xtsn_p"}, {"name": "Acyl phosphatidylglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["apg181_c"]}, "charge": -1, "formula": "C60H110O11P", "compartment": "c", "id": "apg181_c"}, {"name": "(S)-3-Hydroxydodecanoyl-CoA", "notes": {"original_bigg_ids": ["3hddcoa_c"]}, "charge": -4, "formula": "C33H54N7O18P3S", "compartment": "c", "id": "3hddcoa_c"}, {"name": "N-Acetylmuramate", "notes": {"original_bigg_ids": ["acmum_e"]}, "charge": -1, "formula": "C11H18NO8", "compartment": "e", "id": "acmum_e"}, {"name": "2,5-diketo-D-gluconate", "notes": {"original_bigg_ids": ["25dkglcn_c"]}, "charge": -1, "formula": "C6H7O7", "compartment": "c", "id": "25dkglcn_c"}, {"name": "Phenylpropanoate", "notes": 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