# Talk:Chromosome structure via Euclidean Distance Matrices

### From Wikimization

(→E.coli realization) |
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<pre> | <pre> | ||

%%% Ronan Fleming, E.coli molecule data | %%% Ronan Fleming, E.coli molecule data | ||

- | %%% -Jon Dattorro, August 2008 | + | %%% -Jon Dattorro, August 9 2008 |

clear all | clear all | ||

load ecoli | load ecoli | ||

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G = (double(G)-128)/128; % Gram matrix | G = (double(G)-128)/128; % Gram matrix | ||

N = size(G,1); | N = size(G,1); | ||

- | |||

- | D = diag(G)*ones(N,1)' + ones(N,1)*diag(G)' - 2*G; % EDM D | ||

- | |||

- | clear her49imfs12movfull G; | ||

Vn = [-ones(1,N-1); speye(N-1)]; | Vn = [-ones(1,N-1); speye(N-1)]; | ||

- | + | [evec evals flag] = eigs(Vn'*G*Vn, [], 20, 'LA'); | |

- | + | ||

- | + | ||

- | + | ||

- | [evec evals flag] = eigs( | + | |

if flag, disp('convergence problem'), return, end; | if flag, disp('convergence problem'), return, end; | ||

close all | close all | ||

- | + | Xs = [zeros(3,1) sqrt(real(evals(1:3,1:3)))*real(evec(:,1:3))']; % Projection of -VDV on PSD cone rank 3 | |

- | Xs = sqrt(real(evals(1:3,1:3)))*real(evec(:,1:3))'; % Projection of -VDV on PSD cone rank 3 | + | |

plot3(Xs(1,:), Xs(2,:), Xs(3,:), '.') | plot3(Xs(1,:), Xs(2,:), Xs(3,:), '.') | ||

</pre> | </pre> |

## Revision as of 13:56, 9 August 2008

%%% Ronan Fleming, E.coli molecule data %%% -Jon Dattorro, August 9 2008 clear all load ecoli frame = 4; % 1 through 12 G = her49imfs12movfull(frame).cdata; % uint8 G = (double(G)-128)/128; % Gram matrix N = size(G,1); Vn = [-ones(1,N-1); speye(N-1)]; [evec evals flag] = eigs(Vn'*G*Vn, [], 20, 'LA'); if flag, disp('convergence problem'), return, end; close all Xs = [zeros(3,1) sqrt(real(evals(1:3,1:3)))*real(evec(:,1:3))']; % Projection of -VDV on PSD cone rank 3 plot3(Xs(1,:), Xs(2,:), Xs(3,:), '.')

## E.coli realization

I regard the autocorrelation data you provided as a Gram matrix.

Then conversion to a Euclidean distance matrix (EDM) is straightforward -

Chapter 5.4.2 of Convex Optimization & Euclidean Distance Geometry.

The program calculates only the first 20 eigenvalues of an oblique projection of the EDM on a positive semidefinite (PSD) cone -

Chapter 7.0.4 - 7.1 *ibidem*.

You can see at runtime that there are many significant eigenvalues; which means, the Euclidean body (the molecule) lives in a space higher than dimension 3, assuming I have interpreted the E.coli data correctly.

To get a picture corresponding to physical reality, we obliquely project the EDM on the closest rank-3 subset of the boundary of that PSD cone; this means, precisely, we truncate eigenvalues.

It is unlikely that this picture is an accurate representation unless the number of eigenvalues of that projection approaches 3 prior to truncation.

Matlab Figures allow 3D rotation in real time, so you can get a good idea of the body's shape.

I include a low-resolution figure here (frame 4) for reference.